专利号:US-7309799-B2 优先权日:2004-06-01 标 题:Methods for the synthesis of milnacipran and congeners thereof 发明人:BUCHWALD STEPHEN L; SWAGER TIMOTHY M; RARIY ROMAN V 权利人:COLLEGIUM PHARMACEUTICAL INC 摘要:One aspect of the present invention relates to methods for synthesizing milnacipran or congeners thereof. Another aspect of the present invention relates to asymmetric methods for synthesizing enantiomerically enriched milnacipran or congeners thereof. The present invention also relates to methods for synthesizing intermediates useful in the non-asymmetric or asymmetric methods for synthesizing enantiomerically enriched milnacipran or congeners thereof.
专利号:US-2003072716-A1 优先权日:2001-06-22 标 题:Renewable, carbohydrate based CO2-philes 发明人:POOVATHINTHODIYIL RAVEENDRAN; WALLEN SCOTT L 摘要:A composition is disclosed comprising a carbohydrate-based material a dispersed in carbon dioxide. A general method for synthesizing inexpensive, renewable, non-toxic, non-fluorous, carbohydrate based CO 2 -philes is disclosed. These CO 2 -philes are soluble in carbon dioxide. Methods of making the composition are also disclosed. The methods and composition are useful in a variety of applications and can utilize gaseous, liquid and supercritical carbon dioxide. The methods and compositions are useful in the synthesis of surfactants and metal chelates for CO 2 , as a sizing substrate, in CO 2 -based coating processes, for impregnation and plasticizing cellulosic and non-cellulosic materials, in pharmaceutical applications, such as crystallization, dispersion and encapsulation of bioactive molecules in solid systems, in the densification of CO 2 , in the synthesis of biodegradable polymers in CO 2 , and for carbon dioxide removal, to name just a few.
专利号:US-2005282898-A1 优先权日:2004-06-01 标 题 :Methods for the synthesis of milnacipran and congeners thereof
专利号:WO-2005118564-A2 优先权日:2004-06-01 标 题:Methods for the synthesis of milnacipran and congeners thereof
专利号:US-9650341-B2 优先权日:2010-05-04 标 题 :Process for synthesizing oxidized lactam compounds 发明人:REMENAR JULIUS F; BLUMBERG LAURA COOK; ZEIDAN TAREK A 权利人:ALKERMES PHARMA IRELAND LTD 摘要:The invention provides a method for the synthesis of dehydrogenated lactam drugs of Formula I:
摘要:Food and Chemical Toxicology., 20(725), 1982 摘要:Industrial Medicine and Surgery., 41(31), 1972 参考文献:10.1186/s12870-019-1855-2 摘要:Li T, Wu Q, Zhu H, Zhou Y, Jiang Y, Gao H, Yun Z. Comparative transcriptomic and metabolic analysis reveals the effect of melatonin on delaying anthracnose incidence upon postharvest banana fruit peel. BMC Plant Biology. 2019 Jul 01;19(1):289. doi: 10.1186/s12870-019-1855-2.