13345-95-4 + 613-11-6 = 61-73-4 + 83-88-5 反应条件:1.1 Reagents: Artemisinin Solvents: Acetonitrile,Water; Ph 7.4,37 °C 标题:Facile Oxidation Of Leucomethylene Blue And Dihydroflavins By Artemisinins: Relationship With Flavoenzyme Function And Antimalarial Mechanism Of Action 作者:Haynes,Richard K.; Et Al 参考文献:Chemmedchem 日期:2010 卷标:5(8) 页码:1282-1299]
61-73-4 = 61-73-4 + 83-88-5 反应条件:1.1 Reagents: Sodium Dithionite Solvents: Water; Ph 7.42.1 Reagents: Artemisinin Solvents: Acetonitrile,Water; Ph 7.4,37 °C 标题:Facile Oxidation Of Leucomethylene Blue And Dihydroflavins By Artemisinins: Relationship With Flavoenzyme Function And Antimalarial Mechanism Of Action 作者:Haynes,Richard K.; Et Al 参考文献:Chemmedchem 日期:2010 卷标:5(8) 页码:1282-1299
专利号:US-5139940-A 优先权日:1989-10-26 标题 :Activation compounds and methods of synthesis of activation compounds 发明人:ISAACS STEPHEN T; CIMINO GEORGE D; METCHETTE KENNETH C; TESSMAN JOHN W 权利人:ISAACS STEPHEN T; CIMINO GOERGE D; METCHETTE KENNETH C; TESSMAN JOHN W 摘要:The invention is directed to isopsoralen compound compositions that contain a variety of substitutions which yet permit their binding to nucleic acid polymers. Reaction conditions that activate these bound isopsoralens results in covalent crosslinking to the nucleic acid polymers. The resultant complex is inhibited from being a template for the template-directed enzymatic synthesis of a complementary nucleic acid polymer. Beside the isopsoralens compositions, the invention includes their synthesis, the nucleic acid complex production and detection, and the above inhibitory method of use of the isopsoralens.
专利号:US-4609707-A 优先权日:1983-11-10 标题 :Synthesis of polymers containing integral antibodies 发明人:NOWINSKI ROBERT C; HOFFMAN ALLAN S 权利人:GENETIC SYSTEMS CORP 摘要:A method is disclosed for the de novo synthesis of antibody-containing polymers and the preparation of a class of polymerizable compounds used in the synthesis of such antibody-containing polymers. Antibody-containing polymers formed from monomer/antibody conjugates and nonderivatized polymerizable compounds can be varied in formation of the polymer to provide control of (a) molecular spacing, steric accessibility and the number of antibody molecules that are integrally incorporated into the polymer backbone, and (b) the chemical and physical structure of the polymer itself, thus enabling specific tailoring of antibody-containing polymers for particular end-use application. Also disclosed is a method for the selective removal of a compound from a solution or suspension thereof using monomer/receptor conjugates where the compound has the capacity to bind to the receptor in the conjugate. The bound compound is removed by polymerization - induced separation of the monomer/receptor--compound complex from solution.
专利号:US-7094805-B2 优先权日:2001-12-14 标 题 :Total synthesis of merrilactone A 发明人:DANISHEFSKY SAMUEL J; BIRMAN VLADIMIR B 权利人:UNIV COLUMBIA 摘要:This invention provides a total synthesis of Merrillactone and Merrilactone analogues for use as neurotrophic agents in the treatment of neurodegenerative diseases. The invention also provides intermediates for use in the synthesis of Merrilactone and its analogues.
专利号:US-6998484-B2 优先权日:2000-10-04 标 题:Synthesis of purine locked nucleic acid analogues 发明人:KOCH TROELS; JENSEN FLEMMING REISSIG 权利人:SANTARIS PHARMA AS 摘要:The present invention relates to a new method for the synthesis of purine LNA (Locked Nucleic Acid) analogues which provides a higher overall yield. The method comprising a regioselective 9-N purine glycosylation reaction followed by a one-pot nucleophilic aromatic substitution reaction of the 6-substituent in the purine ring and simultaneous nucleophile-induced intramolecular ring closure of the C-branched carbohydrate to form novel purine LNA analogues. The novel strategy is illustrated by the synthesis of the novel compound (1S,3R,4R,7S)-7-benzyloxy-1-methanesulfonylmethyl-3-(guanin-9-yl)-2,5-dioxabicyclo[2.2.1]heptane which is easily converted into (1S,3R,4R,7S)-7-hydroxy-1-hydroxymethyl-3-((2-N-isobutyrylguanin-9-yl)-2,5-dioxabicyclo[2.2.1]heptane after isobutyryl protection of the 2-amino purine group and subsequent substitution of 1-methanesulfonyl with benzoate, debenzoylation and debenzylation.
专利号:WO-2024079704-A1 优先权日:2022-10-13 标题 :Synthesis of derivatives of siphonochilone and therapeutic use thereof 发明人:INVERNIZZI LUKE; MOYO PHANANKOSI; MAHARAJ VINESH 权利人:UNIV PRETORIA 摘要:THIS invention relates to the synthesis of derivatives of siphonochilone and therapeutic use thereof in the treatment and prevention of respiratory virus disease, in particular influenza or a coronavirus disease.
专利号:US-10150160-B2 优先权日:2014-12-04 标题 :Universal one-pot and up-scalable synthesis of SERS encoded nanoparticles 发明人:PAZOS PÉREZ NICOLÃ?S; MIR DE SIMÓN BERNAT 权利人:MEDCOM ADVANCE S A; MEDCOM ADVANCE S A 摘要:The universal one-pot and up-scalable synthesis of SERS encoded nanoparticles relies on the controlled co-absorption of mercaptoundecanoic acid (MUA) and the Raman code on the metallic surfaces of the nanoparticles. In contrast to most of the reported procedures which typically involve complex steps, the present method has demonstrated to be an easy and fast one-pot approach for the production of SERS-encoded nanoparticles. This versatile strategy allows for the SERS codification of particles with every molecule with affinity toward the metal surface, independently of its chemical nature, as exemplified here in the fabrication of 31 different encoded particles using the same standard procedure. In addition to the easiness of preparation, scalability to the liter regime, stability in aqueous solutions including PBS and chemical diversity, our SERS-encoded particles show considerably higher optical efficiency than those fabricated by using PEG or PVP polymers.
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