CAS: 1076-38-6; 4-Hydroxycoumarin

相似化合物

1983-81-9 93-35-6 2732-18-5

上下游产品

CAS号118-93-4 邻羟基苯乙酮 | CAS号105-58-8 碳酸二乙酯 | CAS号31005-07-9 4-烯丙氧基香豆素 | CAS号201230-82-2 carbon monoxide | CAS号66530-08-3 3-carbethoxy-4-... | CAS号616-38-6 碳酸二甲酯 | CAS号75-44-5 光气 | CAS号141-82-2 丙二酸 | CAS号108-95-2 苯酚 | CAS号111222-29-8 2H-1-Benzopyran... | CAS号111222-28-7 4-(2-phenylethy... | CAS号10523-48-5 4-羟基-2-氧代-2H-色烯-3-甲腈 | CAS号10475-15-7 2H-1-Benzopyran... | CAS号10173-87-2 2,4-diphenyl-4H... | CAS号111222-22-1 9-chlor°Chromen... | CAS号109797-42-4 4-cyclohex-2-en... | CAS号111222-25-4 4-苄氨基-2-氧代-2H-色... | CAS号4865-84-3 1,2-苯并异恶唑-3-乙酸 | CAS号66233-72-5 (6-fluoro-benzo...

阿司匹林置于sodium Hydroxide,氯化亚砜,硫酸,尿素体系中,用 乙醇,水,甲苯 用作溶剂,化学反应 6.0H,反应生成4-羟基香豆素
参考文献:4-羟基香豆素的简单且具有成本效益的合成
标题:4-羟基香豆素的简单且具有成本效益的合成
摘要:摘要 描述了从阿司匹林制备 4-羟基香豆素的两种简单且廉价的方法,它们应该易于大规模合成.
Doi:10.1080/00397919908085993

专利信息

专利号:US-7816544-B2
优先权日:2004-03-23
标 题:Synthesis of rocaglamide natural products via photochemical generation of oxidopyrylium species
发明人：JONES II GUILFORD; GERARD BAUDOUIN; PORCO JR JOHN A
权利人:UNIV BOSTON
摘要:The present invention provides new strategies for the synthesis of compounds of the rocaglamide family and related natural products. In particular, the new biomimetic synthetic approach involves photochemical generation of an oxidopyrylium species from a 3-hydroxychromone derivative followed by 1,3-dipolar cycloaddition of the oxidopyrylium species to a dipolarophile. This approach can be used for the formation of adducts containing an aglain core structure. Methods for the conversion of aglain core structures to aglain, rocaglamide and forbaglin ring systems are also provided. The present invention also relates to the use of rocaglamide/aglain/forbaglin derivatives for the manufacture of medicaments for use in the treatment of cancer or cancerous conditions, disorders associated with cellular hyperproliferation, or NF-κB-dependent conditions.

专利号:WO-03050105-A2
优先权日:2001-12-10
标题 :Catalytic asymmetric synthesis of optically active compounds
发明人：HALLAND NIS; JOERGENSEN KARL ANKER; HANSEN TORE
权利人:CHEMINOVA AS; HALLAND NIS; JOERGENSEN KARL ANKER; HANSEN TORE
摘要:A one step catalytic asymmetric process for the synthesis of an optically active compound of formula la or lb wherein R is selected from C1-7 alkyl, C1-7 haloalkyl, C1-7 alkoxy, C1-7 haloalkoxy, halogen and hydroxy; R3 is H or C1-4 alkyl; R4 is selected from H, C1-7 alkyl, C1-7 haloalkyl, C1-7 alkoxy, COOH, CO-C1-7 alkoxy and an optionally substituted aryl or heterocycle; AR represents C1-7 alkyl, optionally substituted aryl, an optionally substituted heterocycle or AR and R4 may be bridged together forming part of a ring system; X is O or S; m is a number between 0-4; comprising the step of reacting a compound of the formula 2 with a compound of formula 3 in the presence of a catalytic amount of a chiral nitrogen containing organic compound.

专利号:US-6512005-B2
优先权日:2001-02-28
标 题:Process for synthesis of pure warfarin acid, warfarin alkali metal salts and corresponding clathrates
发明人：BERCOVICI SORIN; EVRON YUVAL; FUXMAN OSVALDO; JAKOEL MIRELA; SASSON SBAR; ULANENKO KONSTANTIN
权利人:TARO PHARMA IND
摘要:An improved procedure for the purification of warfarin acid. Sodium, potassium and lithium warfarin salts and the corresponding clathrates are prepared in high, pharnacopeial grade purity and good yields from the pure warfarin acid and the respective metal salt bases in suitable media.

专利号:WO-0112791-A1
优先权日:1999-08-12
标 题 :Dna shuffling of dioxygenase genes for production of industrial chemicals
发明人：SELIFONOV SERGEY A; NEWMAN LISA M
权利人:MAXYGEN INC; SELIFONOV SERGEY A; NEWMAN LISA M
摘要:This invention provides improved polypeptides, including dioxygenases, dehydrogenases, ligases and transferases that are useful for the biocatalytic synthesis of compounds such as α-hydroxycarboxylic acids, and aryl- and alkyl-hydroxy and carboxylic acid compounds. The polypeptides provided herein are improved in properties such as regioselectivity, enzymatic activity, stereospecificity, and the like. Methods for obtaining recombinant polynucleotides that encode these improved polypeptides are also provided, as are organisms that express the polypeptides and are thus useful for carrying out said biocatalytic syntheses. Also provided by the invention are methods for increasing said solvent resistance of organisms that are used in the synthetic methods.

专利号:US-2005080260-A1
优先权日:2003-04-22
标 题 :Preparation of prodrugs for selective drug delivery
发明人：MILLS RANDELL L; WU GUO-ZHANG
摘要:Synthesis of a chemical compound having the formula A-B-C that may serve for applications such as drug delivery where A is a chemiluminescent, moiety, B is a photochromic moiety, and C is a biologically active moiety where A-B-C may serve as a prodrug. Novel synthetic methods of the present invention to form the prodrug comprised the steps of (1) forming a benzophenone, (2) forming a diaryl ethylene, (3) attaching a phthalimide moiety to at least one of the aryl groups of the ethylene to form a phthalimide-ethylene conjugate, (4) condensing two ethylene-phthalimide conjugates to form a phthalimide-pentadiene conjugate, (5) converting the phthalimide to the phthalhydrazide by reaction with hydrazine to form a carrier compound according to the present invention, and (6) reacting the carrier compound with an nucleophilic moiety of the drug to form the corresponding prodrug. Alternatively the carrier can be prepared by using the halo-substituted diaryl ethylene to make the corresponding cationic leuco dye-like compound with known methods. The cationic compound then is protected by reacting with a nucleophile and coupled with the aminophathalimide by palladium-catalyzed amination to form the protected phthalimide-pentadiene conjugate. The latter is refluxed with hydrazine to convert its phthalimide to the phthalhydrazide and acidified to give the carrier. An additional aspect of the present invention relates to the use of these compounds as antiviral agents for the treatment of viral infections such as HIV and as anticancer agents for the treatment of cancers such as bowel, lung, and breast cancer.

专利号:CN-117700425-A
优先权日:2023-12-01
标 题 :Synthesis method and application of one-pot two-step synthesis of 2, 4-aryl-4H-pyranocoumarin compound