4-氟-3-甲氧基苯甲酸甲酯置于吡啶,Chromium(Vi) Oxide,Lithium Aluminium Tetrahydride体系中,用 四氢呋喃,二氯甲烷 用作溶剂,化学反应 1.5H,反应生成3-甲氧基-4-氟苯甲醛 参考文献:Compound Of Camptothecin And Preparation And Use Thereof 标题:Compound Of Camptothecin And Preparation And Use Thereof 摘要:本公开涉及一种式i的化合物,以及其药物组合物和用作抗肿瘤药物的用途.
专利号:US-8927560-B2 优先权日:2010-12-06 标 题 :4-Aza-2, 3-didehydropodophyllotoxin compounds and process for the preparation thereof 发明人:AHMED KAMAL; PAIDAKULA SURESH; BANALA ASHWINI KUMAR; ADLA MALLAREDDY; PAPAGARI VENKAT REDDY; JAKI RASHEED TAMBOLI 权利人:AHMED KAMAL; PAIDAKULA SURESH; BANALA ASHWINI KUMAR; ADLA MALLAREDDY; PAPAGARI VENKAT REDDY; JAKI RASHEED TAMBOLI; COUNCIL SCIENT IND RES 摘要:The present invention provides 4-Aza-2,3-didehydropodophyllotoxin compound of general formula A (4a-4z and 4aa-4ae) as useful potential antitumour agents against human cancer cell lines. The present invention further provides a process for the synthesis of 4-Aza-2,3-didehydropodophyllotoxin compounds (4a-4z and 4aa-4ae).
专利号:US-2012053165-A1 优先权日:2009-03-03 标 题:Novel Phenyl Imidazoles and Phenyl Triazoles As Gamma-Secretase Modulators 发明人:ALLEN MARTIN PATRICK; AM ENDE CHRISTOPHER WILLIAM; BRODNEY MICHAEL AARON; DOUNAY AMY BETH; JOHNSON DOUGLAS SCOTT; PETTERSSON MARTIN YOUNGJIN; SCHWARTZ JACOB BRADLEY; TRAN TUAN PHONG 权利人:ALLEN MARTIN PATRICK; AM ENDE CHRISTOPHER WILLIAM; BRODNEY MICHAEL AARON; DOUNAY AMY BETH; JOHNSON DOUGLAS SCOTT; PETTERSSON MARTIN YOUNGJIN; SCHWARTZ JACOB BRADLEY; TRAN TUAN PHONG; PFIZER 摘要:Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula (I) as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.
专利号:US-9423395-B2 优先权日:2013-01-14 标 题:Fluorescent cell cycle probe having M-phase specificity 发明人:CHANG YOUNG-TAE; ZHAI DUANTING; LEE SUNG-CHAN; YUN SEONG-WOOK; JEONG YUN-MI; KANG NAM-YOUNG; PARK SUNG-JIN 权利人:NAT UNIV SINGAPORE; AGENCY SCIENCE TECH & RES 摘要:The present invention is directed to a novel family of fluorophores based on the BODIPY scaffold, and methods for their synthesis. The BODIPY-based fluorophores disclosed herein are used for the selective visualization of cells that exist in the M-phase of the cell cycle. The present invention further relates to methods for the image-based monitoring of mitotic progression in live cells.
专利号:US-7432284-B2 优先权日:2002-09-19 标题 :Estrogen receptor modulators 发明人:PARKER DANN LEROY; WILKENING ROBERT R; MENG DONGFANG; RATCLIFFE RONALD W 权利人:MERCK & CO INC 摘要:The present invention relates to compounds and derivatives thereof, their synthesis, and their use as estrogen receptor modulators. The compounds of the instant invention are ligands for estrogen receptors and as such may be useful for treatment or prevention of a variety of conditions related to estrogen functioning including: bone loss, bone fractures, osteoporosis, metastatic bone disease, Pagets disease, periodontal disease, cartilage degeneration, endometriosis, uterine fibroid disease, hot flashes, increased levels of LDL cholesterol, cardiovascular disease, impairment of cognitive functioning, cerebral degenerative disorders, restenosis, gynecomastia, vascular smooth muscle cell proliferation, obesity, incontinence, and cancer, in particular of the breast, uterus and prostate.
专利号:US-12428380-B2 优先权日:2023-06-28 标 题 :Compounds 发明人:BANISTER SAMUEL; JORGENSEN WILLIAM; TAN JINLONG; WHISH LACHLAN 权利人:Psylo Pty Ltd 摘要:The present disclosure relates generally to compounds, their methods of synthesis, and their use in the treatment of mental illness or central nervous system disorders.
参考文献:10.1007/s00044-015-1375-z 摘要:Hatti I, Sreenivasulu R, Jadav SS, Jayaprakash V, Kumar CG, Raju RR. Synthesis, cytotoxic activity and docking studies of new 4-aza-podophyllotoxin derivatives. Medicinal Chemistry Research. 2015 May 21;24(8):3305–13. doi: 10.1007/s00044-015-1375-z. 参考文献:10.1007/s11224-015-0704-7 摘要:Nieto CI, Cabildo P, Claramunt RM, Cornago P, Sanz D, Torralba MC, Torres MR, Ferraro MB, Alkorta I, Marín-Luna M, Elguero J. The structure of β-diketones related to curcumin determined by X-ray crystallography, NMR (solution and solid state) and theoretical calculations. Structural Chemistry. 2015 Dec 09;27(2):705–30. doi: 10.1007/s11224-015-0704-7.