CAS: 16499-88-0; 3-Butoxypropanamine

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CAS号6959-71-3 3-正-丁氧基丙腈 | CAS号107-13-1 丙烯腈 | CAS号71-36-3 正丁醇 | CAS号542-76-7 β-氯丙腈 | CAS号1656-48-0 2-氰基乙醚 | CAS号109-99-9 四氢呋喃 | CAS号60-29-7 乙醚 | CAS号110-67-8 3-甲氧基丙腈 | CAS号61798-23-0 N,N'-bis(3-buto...

3-正丁氧基丙腈置于ni(Raney) 氢气体系中,化学反应生成3-丁氧基丙胺
参考文献:Aldose Epimerization By Ni(II): Effect Of Ether-Containing Alkylenediamine Ligands
标题:Aldose Epimerization By Ni(II): Effect Of Ether-Containing Alkylenediamine Ligands
摘要:Several N-Substituted Ethylenediamine (En) Ni(II) Derivatives Containing Ether Linkages Were Prepared In Order To Study The Effect Of Ligand Structure On C-2 Epimerization Of Aldohexoses. The Reagent Consisted Of A Ni(II)-Alkylenediamine Derivative In Methanol. The Presence Of Ether Linkages In The Ligand Increased The Solubility Of The Complexes,And Resulted In An Increase In The Rate Of Epimerization. Epimerization occured Rapidly Under Mild Conditions,And The Same Equilibrium Point Was Reached Regardless Of Whether The Reaction Was Started From Glucose Or Mannose. Among The Ligands Studied,N,N'-Dialkylethyl-Enediamine Was The Most Active In C-2 Epimerization.
Doi:10.1016/0008-6215(91)80165-J

专利信息

专利号:US-5877278-A
优先权日:1992-09-24
标题:Synthesis of N-substituted oligomers
发明人：ZUCKERMANN RONALD N; GOFF DANE A; NG SIMON; SPEAR KERRY; SCOTT BARBARA O; SIGMUND AARON C; GOLDSMITH RICHARD A; MARLOWE CHARLES K; PEI YAZHONG; RICHTER LUTZ; SIMON REYNA
权利人:CHIRON CORP
摘要:A solid-phase method for the synthesis of N-substituted oligomers, such as poly (N-substituted glycines) (referred to herein as poly NSGs) is used to obtain oligomers, such as poly NSGs of potential therapeutic interest which poly NSGs can have a wide variety of side-chain substituents. Each N-substituted glycine monomer is assembled from two 'sub-monomers' directly on the solid support. Each cycle of monomer addition consists of two steps: (1) acylation of a secondary amine bound to the support with an acylating agent comprising a leaving group capable of nucleophilic displacement by -NH2, such as a haloacetic acid, and (2) introduction of the side-chain by nucleophilic displacement of the leaving group, such as halogen (as a solid support-bound alpha -haloacetamide) with a sufficient amount of a second sub-monomer comprising an -NH2 group, such as a primary amine, alkoxyamine, semicarbazide, acyl hydrazide, carbazate or the like. Repetition of the two step cycle of acylation and displacement gives the desired oligomers. The efficient synthesis of a wide variety of oligomeric NSGs using automated synthesis technology of the present method makes these oligomers attractive candidates for the generation and rapid screening of diverse peptidomimetic libraries. The oligomers of the invention, such as N-substituted glycines (i.e. poly NSGs) disclosed here provide a new class of peptide-like compounds not found in nature, but which are synthetically accessible and have been shown to possess significant biological activity and proteolytic stability. Combinatorial libraries of cyclic compounds are disclosed wherein the cyclic compounds are comprised of at least one ring structure derived from cyclization of a peptoid backbone. The diversity of product compounds is generated by the sequential addition of substituted submonomers. The combinatorial library includes 10 or more, preferably 100 or more, and more preferably 1,000 or more distinct and different compounds. The library includes each of the product compounds in retrievable and analyzable amounts and preferably includes at least one biologically active compound. Methods of synthesizing the combinatorial libraries and assay devices produced using the libraries are disclosed as is methodology for screening for and obtaining biologically active cyclic organic compounds.

专利号:WO-0140193-A1
优先权日:1999-12-03
标题:Method for the synthesis of pyrazolines
发明人：BOLDI ARMEN M
权利人:CHEMRX ADVANCED TECHNOLOGIES I; BOLDI ARMEN M
摘要:The present invention provides a method for the synthesis of compounds of Formula (I). Also claimed are novel intermediates and their methods of synthesis.

专利号:US-2002103381-A1
优先权日:2000-11-30
标 题 :Method for the synthesis of pyrazolines
发明人：BOLDI ARMEN M
摘要:The present invention provides a method for the synthesis of compounds of Formula I: n n n Also claimed are novel intermediates and their methods of synthesis.

专利号:US-6187923-B1
优先权日:1998-11-09
标题 :Process for the synthesis of quinazolinones
发明人：DENER JEFFREY MARK; LY CUONG QUOC
权利人:AXYS ADVANCED TECHNOLOGIES INC
摘要:The present invention provides a process for synthesizing a compound or a library of compounds of Formula 1A and 1B:

专利号:WO-0053579-A2
优先权日:1999-03-10
标 题:Solid phase synthesis of 4-aminoproline derivatives and/or combinatorial libraries thereof

专利号:EP-0789577-A1
优先权日:1995-06-07
标 题:Synthesis of n-substituted oligomers