专利号:US-4381400-A 优先权日:1981-02-27 标 题 :Process for the synthesis of isosorbide mononitrates 发明人:EMEURY JEAN-MARIE; WIMMER ERIC 权利人:POUDRES & EXPLOSIFS STE NALE 摘要:The invention relates to the synthesis of isosorbide mononitrates. n The process according to the invention consists in reacting a hydrazine derivative with isosorbide dinitrate, in a polar solvent medium. The reaction is preferably carried out at the reflux temperature of the solvent medium, with an excess of the hydrazine derivative. A preferred solvent medium is a mixture of tetrahydrofuran and methanol. The process leads to the preferential formation of isosorbitol-2-mononitrate, which is a coronary vasodilator.
专利号:US-8647823-B2 优先权日:2005-07-22 标 题 :Polynucleotide synthesis on a modified surface 发明人:PARK JOON-WON; HONG BONG-JIN 权利人:PARK JOON-WON; HONG BONG-JIN; POSTECH FOUNDATION; POSCO 摘要:The present invention relates to a method for the synthesis of a polynucleotide on a modified surface of a substrate, wherein the modified surface is obtained by chemically modifying with macromolecules in which a plurality of termini of the branched region are bound to the surface and a terminus of the linear region is functionalized.
专利号:US-2005214310-A1 优先权日:2004-01-23 标 题 :Melphalan prodrugs 发明人:TOKI BRIAN E; SENTER PETER D 权利人:SEATTLE GENETICS INC 摘要:Shown and described are the synthesis of more potent forms of C-Mel, a prodrug used in Antibody-Directed Enzyme Prodrug Therapy, that releases the clinically used anticancer alkylating agent melphalan extracellularly. Shown and described are the synthesis of a variety of melphalan analogues with the intention to promote facile intracellular drug access. Esters, amides, and peptides of melphalan are shown. Cephalosporin prodrugs of the most interesting melphalan derivatives were synthesized and evaluated for potency, toxicity, therapeutic window, plasma stability, and solubility.
专利号:US-5882901-A 优先权日:1991-06-10 标 题:Modified sialyl Lewisa compounds 发明人:VENOT ANDRE P; NIKRAD PANDURANG V; KASHEM MOHAMMED A 权利人:ALBERTA RES COUNCIL 摘要:The present invention is drawn to methods for the synthesis of Lewis a derivatives modified at the C-2 and/or C-6 position of GlcNAc employing chemo-enzymatic synthesis. The derivatives find use in the treatment and prevention of diseases.
专利号:US-2012259073-A1 优先权日:2004-04-13 标 题 :Methods for the synthesis of modular poly(phenyleneethynylenes) and fine tuning the electronic properties thereof for the functionalization of nanomaterials
专利号:US-2009203867-A1 优先权日:2004-04-13 标 题 :Methods for the synthesis of modular poly(phenyleneethynylenes) and fine tuning the electronic properties thereof for the functionalization of nanomaterials
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