CAS: 3248-93-9; 4-((4-Aminophenyl)(4-Iminocyclohexa-2,5-Dien-1-Ylidene)Methyl)-2-Methylaniline

专利信息

专利号:US-2005080260-A1
优先权日:2003-04-22
标 题 :Preparation of prodrugs for selective drug delivery
发明人：MILLS RANDELL L; WU GUO-ZHANG
摘要:Synthesis of a chemical compound having the formula A-B-C that may serve for applications such as drug delivery where A is a chemiluminescent, moiety, B is a photochromic moiety, and C is a biologically active moiety where A-B-C may serve as a prodrug. Novel synthetic methods of the present invention to form the prodrug comprised the steps of (1) forming a benzophenone, (2) forming a diaryl ethylene, (3) attaching a phthalimide moiety to at least one of the aryl groups of the ethylene to form a phthalimide-ethylene conjugate, (4) condensing two ethylene-phthalimide conjugates to form a phthalimide-pentadiene conjugate, (5) converting the phthalimide to the phthalhydrazide by reaction with hydrazine to form a carrier compound according to the present invention, and (6) reacting the carrier compound with an nucleophilic moiety of the drug to form the corresponding prodrug. Alternatively the carrier can be prepared by using the halo-substituted diaryl ethylene to make the corresponding cationic leuco dye-like compound with known methods. The cationic compound then is protected by reacting with a nucleophile and coupled with the aminophathalimide by palladium-catalyzed amination to form the protected phthalimide-pentadiene conjugate. The latter is refluxed with hydrazine to convert its phthalimide to the phthalhydrazide and acidified to give the carrier. An additional aspect of the present invention relates to the use of these compounds as antiviral agents for the treatment of viral infections such as HIV and as anticancer agents for the treatment of cancers such as bowel, lung, and breast cancer.

专利号:US-2025164360-A1
优先权日:2022-06-09
标 题:On-slide synthesis of a schiff reagent
发明人：BIRD JEAN MARIE; CANTORIA MARY JO CASTRO; DURRANT EDWARD E; HANNON ANDREW
权利人:VENTANA MED SYST INC
摘要:The present disclosure is directed to compositions, kits, and methods for synthesizing a Schiff's reagent in situ, i.e., directly on a substrate, such as within a puddle disposed on the surface of a substrate. In some embodiments, the kits comprise at least a dye composition and a sulfite composition. In some embodiments, the dye composition comprises a compound having a 4-Benzhydrylidene-2,5-cyclohexadien-1-imine core functionalized to include at least two substituted or unsubstituted amine groups, wherein the compound has a molecular weight ranging from between about 300 g/mol to about 600 g/mol. In some embodiments, the dye composition optionally includes an acid. In some embodiments, the sulfite composition comprises a sulfite or SO2 source.

专利号:US-4678613-A
优先权日:1981-12-09
标题:Process for the purification of triphenylmethane compounds
发明人：FLORES ROBERT J
权利人:PMC SPECIALTIES GROUP INC
摘要:Triphenylmethane dyes are obtained in a purified or more concentrated condition which eliminates the excess aromatic amines and by-products obtained during the synthesis of the triphenylmethane dyes. These purified triphenylmethane dyes show special utility when used in combination with an electron acceptor (Lewis acid) to produce carbonless copy paper or when used as reactants in the manufacture of other dyes.

专利号:US-4448446-A
优先权日:1981-12-09
标题:Process for the purification of triphenylmethane compounds and pressure sensitive copysheet containing same
发明人：FLORES ROBERT J
权利人:SHERWIN WILLIAMS CO
摘要:Triphenylmethane dyes are obtained in a purified or more concentrated condition which eliminates the excess aromatic amines and by-products obtained during the synthesis of the triphenylmethane dyes. These purified triphenylmethane dyes show special utility when used in combination with an electron acceptor (Lewis acid) to produce carbonless copy paper or when used as reactants in the manufacture of other dyes.

专利号:CN-119343410-A
优先权日:2022-06-09
标题 :On-slide synthesis of schiff reagent

专利号:US-2003186237-A1
优先权日:2001-02-14
标题:Methods and compositions of amplifying RNA
发明人：GINSBERG STEPHEN D; CHE SHAOLI
权利人:BAYLOR COLLEGE MEDICINE
摘要:The present invention pertains to a method that will increase the efficiency of second strand cDNA synthesis through a mechanism of “terminal continuationâ€? before further RNA amplification by RNA transcription using, for example, a bacteriophage promoter. In a specific embodiment, a transcription promoter is attached to the 5′ region of cDNA through the same mechanism of “terminal continuationâ€?. Genetic signals are subsequently amplified in a linear manner through RNA transcription. In specific embodiments, the orientation of the transcribed RNA is either sense or antisense, depending on the desired downstream application. In other embodiments, the present invention pertains to methods for extraction and amplification of RNA, particularly mRNA, from histologically stained tissues and cells.