CAS: 34893-92-0; 3,5-Dichlorophenylisocyantae

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3,5-二氯苯甲酸置于叠氮磷酸二苯酯,三乙胺体系中,用 甲苯 用作溶剂,化学反应 0.67H,反应生成3,5-二氯苯异氰酸酯
参考文献:金黄色葡萄球菌 Rnpa 抑制剂:计算指导设计,合成和初步生物学评价
标题:金黄色葡萄球菌 Rnpa 抑制剂:计算指导设计,合成和初步生物学评价
摘要:抗生素耐药性正在全球蔓延,已成为现代医学中最重要的问题之一.在这种情况下,细菌 Rna 降解和加工机制是细菌活力的基本过程,可用于抗菌治疗.在金黄色葡萄球菌中,Rnpa 被假设为这些机制的主要参与者之一.金黄色葡萄球菌rnpa 能够调节 Mrna 降解并与核酶 ( Rnpb),促进 Ptrna 成熟.相应的小分子筛选活动最近确定了几类 Rnpa 抑制剂,它们的结构活性关系 (Sar) 仅被部分探索.因此,在目前的工作中,使用金黄色葡萄球菌的计算建模rnpa 我们确定了已知 Rnpa 抑制剂的假定关键相互作用,并且我们使用这些信息来设计,合成和生物学评估新的潜在 Rnpa 抑制剂.目前的结果可能有助于全面了解属于 Rnpa2000 样氨基硫脲和 Jc 样哌啶甲酰胺分子类别的 Rnpa 抑制剂.我们评估了不同关键部分的重要性,例如 Jc2 的二氯苯基和哌啶,以及 Rnpa2000 的半硫代卡
Doi:10.3390/antibiotics10040438

专利信息

专利号:US-4921997-A
优先权日:1988-06-15
标题 :Method of synthesis and novel compounds for pharmaceutical uses
发明人：LALEZARI IRAJ; LALEZARI PARVIZ
权利人:MONTEFIORE MED CENTER
摘要:The present invention is concerned with a process for the synthesis of substituted arylureidophenexymethyl propionic acids and an analogous benzamides series of compounds which have activity in the dissociation of oxygen from hemoglobin. In addition, the process may be utilized to prepare compounds which are known.

专利号:US-8188113-B2
优先权日:2006-09-14
标 题 :Dihydropyridopyrimidinyl, dihydronaphthyidinyl and related compounds useful as kinase inhibitors for the treatment of proliferative diseases
发明人：FLYNN DANIEL L; PETILLO PETER A; KAUFMAN MICHAEL D; PATT WILLIAM C
权利人:FLYNN DANIEL L; PETILLO PETER A; KAUFMAN MICHAEL D; PATT WILLIAM C; DECIPHERA PHARMACEUTICALS INC
摘要:The present invention relates to novel dihydropyridopyrimidinyl, dihydronaphthyridinyl, and related compounds which are kinase inhibitors and modulator useful for the treatment of various diseases. More particularly, the invention is concerned with such compounds, kinase/compound adducts, methods of treating diseases, and methods of synthesis of the compounds. Preferably, the compounds are useful for the modulation of kinase activity of Raf kinases and disease polymorphs thereof. Compounds of the present invention find utility in the treatment of mammalian cancers and especially human cancers including but not limited to malignant melanoma, colorectal cancer, ovarian cancer, papillary thyroid carcinoma, non small cell lung cancer, and mesothelioma. Compounds of the present invention also find utility in the treatment of rheumatoid arthritis and retinopathies including diabetic retinal neuropathy and macular degeneration.

专利号:US-8598239-B2
优先权日:2010-10-11
标题 :Anderson-type heteropoly compound-based catalyst compositions and their use conversion of synthesis gas to oxygenates
发明人：MANIKANDAN PALANICHAMY; BARTON DAVID G; MILLAR DEAN M
权利人:MANIKANDAN PALANICHAMY; BARTON DAVID G; MILLAR DEAN M; DOW GLOBAL TECHNOLOGIES LLC
摘要:Use a transition metal-containing, Anderson-type heteropoly compound catalyst to convert synthesis gas to an oxygenate, especially an alcohol that contains from one carbon atom to six carbon atoms.

专利号:US-2007264189-A1
优先权日:2005-05-19
标题 :Synthesis of Metal-Metal Oxide Catalysts and Electrocatalysts Using a Metal Cation Adsorption/Reduction and Adatom Replacement by More Noble Ones

专利号:CN-106008268-A
优先权日:2016-05-18
标题:Synthesis of 3,5-dichlorophenyl isocyanate thermo-optical reaction tail gas recovery and recycling method of phosgene

专利号:RU-2454390-C2
优先权日:2006-04-21
标 题:Synthesis of aromatic compounds from methane