CAS: 46004-37-9; Methyl 4-Amino-2-Chlorobenzoate

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CAS号13324-11-3 2-氯-4-硝基苯甲酸甲酯 | CAS号67-56-1 甲醇 | CAS号2457-76-3 4-氨基-2-氯苯甲酸 | CAS号77-78-1 硫酸二甲酯 | CAS号75-36-5 乙酰氯 | CAS号38667-55-9 2-METHYL-PARA-A... | CAS号7073-36-1 2-氯-4-硝基苯甲酰氯 | CAS号99-60-5 2-氯-4-硝基苯甲酸 | CAS号168079-32-1 利赛伐坦 | CAS号168080-49-7 2-氯-4-(5-氟-2-甲基... | CAS号53250-84-3 2-氯-4-氨磺酰基苯甲酸

2-氯-4-硝基苯甲酰氯置于palladium On Activated Charcoal 吡啶,氢气体系中,化学反应生成 2-氯-4-氨基苯甲酸甲酯
参考文献:新型ag 957类似物的合成,构效关系和p210(bcr-Abl)蛋白酪氨酸激酶活性.
标题:新型ag 957类似物的合成,构效关系和p210(bcr-Abl)蛋白酪氨酸激酶活性.
摘要:设计并合成了一系列新型的,空间受限的ag 957亲脂性类似物,作为潜在的蛋白酪氨酸激酶(ptk)抑制剂.研究了这些ptk抑制剂的体外活性,体内抗白血病活性和药理作用.讨论了与羧酸,苯酚环和连接基修饰相关的结构活性关系的某些方面.我们已经证明1,4-氢醌部分对于活性是必不可少的,并且位阻酯有助于增强体内功效.adaphostin(nsc 680410)已作为改良的化合物出现,具有最大的体内抗白血病中空纤维活性,与最初的铅化合物ag 957一致.目前,Adaphostin正在临床前毒理学研究中.
DOI:10.1016/j.Bmc.2004.12.003

专利信息

专利号:US-9700543-B2
优先权日:2011-05-31
标题 :GLP-1 receptor stabilizers and modulators
发明人：BOEHM MARCUS F; MARTINBOROUGH ESTHER; MOORJANI MANISHA; TAMIYA JUNKO; HUANG LIMING; FOWLER THOMAS; NOVAK ANDREW; MEGHANI PREMJI; BRAHMACHARY ENUGURTHI; YEAGER ADAM RICHARD
权利人:CELGENE INT II SÀRL
摘要:Compounds that bind the glucagon-like peptide 1 (GLP-1) receptor, methods of their synthesis, methods of their therapeutic and/or prophylactic use, and methods of their use in stabilizing GLP-1 receptor in vitro for crystallization of the GLP-1 receptor are provided. Certain compounds may have activity as modulators or potentiators with respect to glucagon receptor, GIP receptor, GLP-1 and GLP-2 receptors, and PTH receptor on their own or in the presence of receptor ligands such as GIP(1-42), PTH(1-34), Glucagon(1-29), GLP-2(1-33), GLP-1(7-36), GLP-1(9-36), oxyntomodulin and exendin variants.