CAS: 4635-59-0; 4-Chlorobutyryl Chloride

相似化合物

6139-84-0 1575-61-7 19347-73-0

上下游产品

4-butanolide tetrachloromethane phosgene Dichloromethyl methyl ether 1,5-Dichloro-2-pentanone 4-chloro-1-(morpholin-4-yl)butan-1-one N-(p-tolyl)-4-chlorobutyramide p-methoxyphenyl cyclopropyl ketone

4-氯丙酸置于草酰氯,N,N-二甲基甲酰胺体系中,用 二氯甲烷 作为反应溶剂,化学反应 4.0H,反应生成 4-氯丁酰氯
参考文献:基于西伯利亚冷杉和(+)-樟脑的(-)-冰片酚发现一种新型的痘苗病毒抑制剂.
标题:基于西伯利亚冷杉和(+)-樟脑的(-)-冰片酚发现一种新型的痘苗病毒抑制剂.
摘要:设计并合成了一系列带有含n杂环的冰片酯/酰胺衍生物,作为痘苗病毒(vv)抑制剂.生物测定结果表明,在设计的化合物中,衍生物6,13,14,34,36和37对vv的抑制作用最佳,Ic50值分别为12.9,17.9,3.4,2.5,12.5和7.5μm,效果非常好.细胞毒性.初步的结构-活性关系(sar)研究表明,饱和的n-杂环(例如吗啉或4-甲基哌啶)与1,7,7-三甲基双环[2.2.1]庚烷骨架的组合有利于抗病毒活性.
DOI:10.1002/cbdv.201800153

专利信息

专利号:US-5190671-A
优先权日:1990-10-03
标题:Process for the synthesis of monohaloalkanoylferrocenes
发明人：CAUBERE PAUL; FORT YVES; GAUTIER JEAN-CLAUDE; MONDET JEAN-CLAUDE
权利人:POUDRES & EXPLOSIFS STE NALE
摘要:The present invention relates to a process for the synthesis of monohaloalkanoylferrocenes of general formula (I) in which X=Cl, Br, n is an integer such that 2 in which R1 and R2 have the abovementioned meaning, is reacted at a temperature -5 DEG C.< theta r<+15 DEG C., in the presence of AlCl3 with a halide or the anhydride of an acid of general formula (III) HOOC-(CH2)n-X, X and n having the abovementioned meaning. An acylating solution obtained by mixing AlCl2 and the acid halide or anhydride in CH2Cl2, whose temperature theta a is such that 5 DEG C.
专利号:US-5214175-A
优先权日:1990-09-27
标 题:Process for the synthesis of monohaloalkylferrocenes and 4-chlorobutylferrocene
发明人：GAUTIER JEAN-CLAUDE; MELIN JEAN-GUY; MONDET JEAN-CLAUDE
权利人:POUDRES & EXPLOSIFS STE NALE
摘要:The present invention relates to a process for the synthesis of a monohaloalkylferrocene by reaction of hydrogen with a monohaloalkanoylferrocene in the presence of PtO2 and SnCl2 as catalyst in an acetic acid medium. In this manner, a crude, particularly pure synthetic product is obtained in a high yield, simply and inexpensively. The monohaloalkylferrocenes are especially useful as surfactants or as intermediates for the synthesis of combustion catalysts for propergols. The present invention also relates to a novel monohaloalkylferrocene, namely 4-chlorobutylferrocene.

专利号:US-5550267-A
优先权日:1994-06-14
标 题:Process for the synthesis of haloalkylferrocenes
发明人：GRAINDORGE HERVE; MONDET JEAN-CLAUDE; VINCENT CHARLES-HENRY
权利人:POUDRES & EXPLOSIFS STE NALE
摘要:The present invention relates to a process for the synthesis of haloalkylferrocenes, comprising a first stage of reaction, in the presence of AlCl 3 as catalyst and in organic solvent medium, of a carboxylic acid halide or anhydride with ferrocene or an alkylferrocene. n After this stage, without prior isolation of the intermediate compound, a metal hydride is added to the reaction mixture. n The haloalkylferrocenes are particularly useful as intermediates in the synthesis of combustion catalysts for propellants.

专利号:EP-1641729-B1
优先权日:2003-07-09
标题:Use of functionalized onium salts as a soluble support for organic synthesis
发明人：VAULTIER MICHEL; GMOUH SAID; HASSINE FATIMA
权利人:CENTRE NAT RECH SCIENT; UNIV RENNES
摘要:The invention relates to the use of a onium salt functionalized by at least one organic function, as a soluble support, in the presence of at least one organic solvent, for organic synthesis of a molecule, in a homogenous phase, by at least one transformation of said organic function. The onium salt enables the synthesized molecule to be released. The onium salt is present in liquid or solid form at room temperature and corresponds to formula A₁⁺, X₁^-, wherein A₁⁺ represents a cation and X₁^- represents an anion.

专利号:US-12006301-B1
优先权日:2021-05-13
标题 :And synthesis of dual 5-HT1A and 5-HT7 receptor ligands
发明人：ABLORDEPPEY SETH Y
权利人:FLORIDA A&M UNIV
摘要:Novel dual 5-HT1A and 5-HT7 receptor ligands and methods of using the novel ligands to treat a neurological disorder are presented.

专利号:US-8664417-B2
优先权日:2009-10-19
标题 :Process for the synthesis of 4-(dimethylsilyl) butylferrocene
发明人：PRADHAN BRAJA SUNDAR
权利人:PRADHAN BRAJA SUNDAR; CBZ CHEMICALS LTD
摘要:The invention provides for a process for the preparation of a silylferrocene compound, comprising the steps of treating ferrocene with a 4-chloroalkyryl chloride in the presence of an lewis acid catalyst and an organic solvent to obtain the acylated product, reducing the acylated product to obtain the 4-chloralkylferrocene, treating the 4-chloroalkylferroce with a metal under Grignard reaction conditions to form its corresponding Grignard intermediate compound; and reacting with chloroalkylsilane in-situ to give the silylferrocene compound. The silylferrocene compound 4-(dimethylsilyl)butylferrocene can be prepared by the process of the invention.