专利号:WO-2012152438-A1 优先权日:2011-05-11 标题 :Process for the preparation of nitrate acid ester of organic compounds 发明人:BONFANTI ANNALISA; STORONI LAURA; RONSIN GAEL 权利人:NICOX SA; BONFANTI ANNALISA; STORONI LAURA; RONSIN GAEL 摘要:The present invention relates to a one-step process for the synthesis of nitric acid esters or 15 N isotopically labeled nitrate esters of organic compounds starting from the correspondent alcohols. Formula (I).
专利号:US-2004053999-A1 优先权日:1997-09-17 标题 :Novel compounds and methods for synthesis and therapy 发明人:BISCHOFBERGER NORBERT W; DAHL TERRENCE C; HITCHCOCK MICHAEL J M; KIM CHOUNG U; LEW WILLARD; LIU HONGTAO; MILLS ROGER G; WILLIAMS MATTHEW A 摘要:Novel compounds are described. The compounds generally comprise an acidic group, a basic group, a substituted amino or N-acyl and a group having an optionally hydroxylated alkane moiety. Pharmaceutical compositions comprising the inhibitors of the invention are also described. Methods of inhibiting neuraminidase in samples suspected of containing neuraminidase are also described. Antigenic materials, polymers, antibodies, conjugates of the compounds of the invention with labels, and assay methods for detecting neuraminidase activity are also described.
专利号:US-6225341-B1 优先权日:1995-02-27 标 题:Compounds and methods for synthesis and therapy 发明人:BISCHOFBERGER NORBERT W; KIM CHOUNG U; LEW WILLARD; LIU HONGTAO; WILLIAMS MATTHEW A 权利人:GILEAD SCIENCES INC 摘要:Novel compounds are described. The compounds generally comprise an acidic group, a basic group, a substituted amino or N-acyl and a group having an optionally hydroxylated alkane moiety. Pharmaceutical compositions comprising the inhibitors of the invention are also described. Methods of inhibiting neuraminidase in samples suspected of containing neuraminidase are also described. Antigenic materials, polymers, antibodies, conjugates of the compounds of the invention with labels, and assay methods for detecting neuraminidase activity are also described.
专利号:US-4346242-A 优先权日:1980-06-05 标 题:Method for preparing substituted meta-phenylalkoxynitrobenzenes 发明人:SPATZ DAVID M 权利人:AMERICAN CYANAMID CO 摘要:Methods for the preparation of substituted meta-phenylalkoxynitrobenzenes and their use as starting materials for the synthesis of herbicidal meta-phenylalkoxyphenylurea.
专利号:WO-2011159910-A2 优先权日:2010-06-17 标题 :Biocatalysts and methods for the synthesis of (s)-3-(1-aminoethyl)-phenol
专利号:EP-2582799-A2 优先权日:2010-06-17 标 题:Biocatalysts and methods for the synthesis of (s)-3-(1-aminoethyl)-phenol
[参考文献]: Kuo-Ching Wen, Et Al. Tyrosol And Its Analogues Inhibit Alpha-Melanocyte-Stimulating Hormone Induced Melanogenesis. Int J Mol Sci. 2013 Nov 28;14(12):23420-40.
合成参考文献
摘要:Aitken, R. A., Science of Synthesis Knowledge Updates, (2018) 3, 314. 摘要:Zhang, Z.; Tong, R., Science of Synthesis Knowledge Updates, (2019) 2, 397. 摘要:Treacy, S. M.; Zhang, X.; Rovis, T., Science of Synthesis, (2021) , 627.