CAS: 623-24-5; 1,4-Bis(Bromomethyl)Benzene

上下游产品

para-xylene p-xylylene glycol formaldehyd benzyl bromide p-xylylene-bis-pyrrolidinium; dibromide1,1'-dimethyl-1,1'-p-xylylene-bis-pyrrolidinium; dibromide 1,1'-(1,4-phenylene-bis(methylene))bis(1-ethylpiperidinium) dibromide p-xylylene-bis-morpholinium; dibromide4,4'-dimethyl-4,4'-p-xylylene-bis-morpholinium; dibromide 1,1'-[1,4-phenylenebis(methylene)]bis(pyridinium) dibromide

对苯二甲醇置于silphos,溴体系中,用 乙腈 作为反应溶剂,化学反应 0.17H,以97%的收率获得产物1,4-二(溴甲基)苯
参考文献:二氧化硅膦(silphos):一种可过滤的试剂,用于将醇和硫醇转化为烷基溴和碘化物
标题:二氧化硅膦(silphos):一种可过滤的试剂,用于将醇和硫醇转化为烷基溴和碘化物
摘要:引入了一种新型的异质试剂硅膦(silphos)[p(cl)3− N(sio 2)n].在x 2(x = Br,I)存在下,在回流的ch 3 Cn中,该试剂可以高产率到定量产率将醇和硫醇转化为其相应的溴化物和碘化物.silphos的使用为通过简单过滤轻松分离silphos氧化物副产物提供了一种高度实用的方法.
DOI:10.1016/j.Tet.2005.01.115

专利信息

专利号:US-2024425446-A1
优先权日:2023-06-23
标题:Dichloromethane-free synthesis of cyclopropenimines
发明人：HEDRICK JAMES L; CAMPOS LUIS M; PARK NATHANIEL H; WU DINO
权利人:IBM; THE TRUSTEE OF COLUMBIA UNIV IN THE CITY OF NEW YORK
摘要:A process of forming a cyclopropenimine (CPI) is disclosed. The process includes obtaining a solution of pentachlorocyclopropane (PCC) dissolved in a first solvent and adding a secondary amine to the solution. The process further includes obtaining precipitated products, including a CPI chloride (CPI−Cl) salt and a secondary amine salt, of a reaction between the secondary amine and the PCC and mixing the precipitated products in a second solvent. The CPI−Cl salt is substantially soluble in the second solvent and the secondary amine salt is substantially insoluble in the second solvent. A CPI composition, an apparatus containing the CPI composition, a process of capturing carbon dioxide (CO2) with the CPI composition, and a process of generating carbonate with the CPI composition are also disclosed.

专利号:US-6162882-A
优先权日:1996-07-10
标 题:Preparation of novel homo- and copolymers using atom transfer radical polymerization
发明人：MATYJASZEWSKI KRZYSZTOF; COCA SIMION; GAYNOR SCOTT G; NAKAGAWA YOSHIKI; JO SEONG MU
权利人:UNIV CARNEGIE MELLON
摘要:The present invention is directed to a process of atom (or group) transfer radical polymerization for the synthesis of novel homopolymer or a block or graft copolymer, optionally containing at least one polar group, with well defined molecular architecture and narrow polydipersity index, in the presence of an initiating system comprising (i) an initiator having a radically transferrable atom or group, (ii) a transition metal compound, and (iii) a ligand, the present invention is also directed to the synthesis of a macromolecule having at least two halogen groups which can be used as a macroinitiator component (i) to subsequently form a block or graft copolymer by an atom or group transfer radical polymerization process; the present invention is also directed to a process of atom or group transfer radical polymerization for the synthesis of a branched or hyperbranched polymer; in addition, the present invention is directed to a process of atom or group transfer radical polymerization for the synthesis of a macroinitiator which can subsequently be used to produce a block or graft copolymer.

专利号:US-7189864-B2
优先权日:1990-11-19
标 题:Method of preparing intermediates useful in synthesis of retroviral protease inhibitors
发明人：NG JOHN S; PRZYBYLA CLAIRE A; MUELLER RICHARD A; VAZQUEZ MICHAEL L; GETMAN DANIEL P
权利人:SEARLE & CO
摘要:A synthesis is described for intermediates which are readily amenable to the large scale preparation of hydroxyethylurea-based chiral HIV protease inhibitors. The method includes forming a diastereoselective epoxide from a chiral alpha amino aldehyde.

专利号:US-6320058-B2
优先权日:2000-02-25
标题:Process for the preparation of isoindoline
发明人：SOUVIE JEAN-CLAUDE; FUGIER CLAUDE; LECOUVE JEAN-PIERRE
权利人:ADIR
摘要:Process for the industrial synthesis of isoindoline by catalytic hydrogenation of phthalonitrile, and its application in the synthesis of 2-(S)-benzyl-4-oxo-4-(cis-perhydroisoindol-2-yl)-butyric acid, its pharmaceutically acceptable salts and its hydrates.

专利号:US-9512250-B2
优先权日:2012-02-23
标 题 :Manganese catalyzed photopolymerization of fluorinated monomers
发明人：ASANDEI ALEXANDRU D
权利人:UNIV CONNECTICUT
摘要:The disclosure discloses initiating systems for the radical polymerization of alkenes, and especially fluorine substituted alkenes. The polymerization is catalyzed by a metal carbonyl, preferably manganese carbonyl. The polymerization is initiated directly from alkyl halides at room temperature under visible white light. The polymers also allow the synthesis of block copolymers. The process comprises polymerizing at least one alkene monomer in the presence of a halide radical initiator, carbonyl catalyst and a solvent, under reaction conditions and for a time sufficient to polymerize the at least one alkene monomer to form a polymer. The present disclosure provides a method for living polymerization of alkene monomers which provides a high level of macromolecular control over the polymerization process and which leads to uniform and controllable polymeric products. This disclosure also provides a method for activating any halide (Cl, Br, I) chain ends of such polymers for the synthesis of block copolymerizations.

专利号:US-6022996-A
优先权日:1990-11-19
标 题 :Method for making intermediates useful in synthesis of retroviral protease inhibitors
发明人：NG JOHN S; PRZYBYLA CLAIRE A; MUELLER RICHARD A; VAZQUEZ MICHAEL L; GETMAN DANIEL P
权利人:SEARLE & CO
摘要:A synthesis is described for intermediates which are readily amenable to the large scale preparation of hydroxyethylurea-based chiral HIV protease inhibitors. The method includes forming a diastereoselective epoxide from a chiral alpha amino aldehyde.