CAS: 66648-45-1; (E)-N-(2-Hydroxy-2-(4-Hydroxyphenyl)Ethyl)-3-(4-Hydroxyphenyl)Acrylamide

上下游产品

°Ctopamine 4-hydroxycinnamic acid N-hydroxysuccinimide ester p-Coumaric Acid 4-hydroxy-benzaldehydetriacetyl N-trans-p-coumaroyl °Ctopamine

对羟基苯甲醛 在 哌啶,吡啶,(Benzotriazo-1-Yloxy)Tris(Dimethylamino)Phosphonium Hexafluorophosphate体系中,用 N,N-二甲基甲酰胺作为反应溶剂,获得 (-)-Trans-N-P-Coumaroyl octopamine
参考文献:Synthesis And Structure-Activity Relationships And Effects Of Phenylpropanoid Amides Of octopamine And Dopamine On Tyrosinase Inhibition And Antioxidation
标题:Synthesis And Structure-Activity Relationships And Effects Of Phenylpropanoid Amides Of octopamine And Dopamine On Tyrosinase Inhibition And Antioxidation
摘要:Phenylpropanoid Amides Of octopamine (Oa) 1A-1E And Dopamine (Da) 2A-2E Were Synthesised And The Structure-Activity Relationships (Sars) For Antioxidant And Tyrosinase Inhibition Activities Were Analysed. Among Synthesised Compounds,2C,Which Contains Two Catechol Moieties,Exhibited The Most Dpph Radical-Scavenging Activity (Ec50 = 16.2 +/-2.41 Mu M),And Id Exhibited Significant Tyrosinase Inhibitory Activity (Ic50 = 5.3 +/-1.8 Mu M). Interestingly,With The Same Acid Moiety,Oa Derivatives Showed More Inhibitory Effect On Tyrosinase Than Did Compounds Derived From Da,Whereas Da Derivatives Were Found To Have Higher Antioxidant Activity Than Compounds Derived From Oa. The Relationship Between Their Structures And Their Potencies,Demonstrated In The Current Study,Will Be Useful For The Design Of Optimal Agents. (C) 2012 Elsevier Ltd. All Rights Reserved.
Doi:10.1016/J.Foodchem.2012.02.152