CAS: 848774-96-9; 2-(Chloromethyl)Nicotinonitrile

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4370-22-3 1721-23-9 116986-12-0

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CAS号115012-11-8 3-Pyridinecarbo...

2-(羟基甲基)烟酰胺置于氯化亚砜,三乙胺,三氟乙酸酐体系中,用 乙腈,二氯甲烷 作为反应溶剂,化学反应生成 2-(氯甲基)-3-氰基吡啶
参考文献:[de] 8-[3-Amino-Piperidin-1-Yl]-Xanthine,Deren Herstellung Und Deren Verwendung Als Dpp-Iv Hemmer 8-[3-Amino-Piperidin-1-Yl]-Xanthine,The Production Thereof And The Use In The Form Of A Dpp Inhibitor[fr] 8-[3-Amino-Piperidine-1-Yl]-Xanthines,Leur Fabrication Et Leur Utilisation Comme Inhibiteur De Dpp-Iv
标题:[de] 8-[3-Amino-Piperidin-1-Yl]-Xanthine,Deren Herstellung Und Deren Verwendung Als Dpp-Iv Hemmer 8-[3-Amino-Piperidin-1-Yl]-Xanthine,The Production Thereof And The Use In The Form Of A Dpp Inhibitor[fr] 8-[3-Amino-Piperidine-1-Yl]-Xanthines,Leur Fabrication Et Leur Utilisation Comme Inhibiteur De Dpp-Iv
摘要:本发明涉及通式(i)中的取代黄嘌呤,其中r如权利要求1所定义,其互变异构体,立体异构体,混合物和盐,具有有价值的药理特性,特别是对二肽基肽酶-Iv(dpp-Iv)酶活性的抑制作用.

专利信息

专利号:US-9090560-B2
优先权日:2013-09-04
标 题 :Process for microwave assisted synthesis of N-methyl pyrrolidone
发明人：KHATRI PRAVEEN KUMAR; JAIN SUMAN LATA; CHATERJEE ALOK KUMAR; BIR SAIN
权利人:COUNCIL SCIENT IND RES
摘要:The present invention relates to a process for microwave assisted synthesis of N-methyl pyrrolidone (NMP). Particularly the process relates to the synthesis of N-methyl succinimide or corresponding analogs by using microwave irradiation which on hydrogenation in the presence of a hydrogenating catalyst gives N-methyl pyrrolidone. Compared to the conventional heating microwave process requires less energy inputs and reduces the reaction time drastically from 5-6 h to 2-5 min.

专利号:US-2008221377-A1
优先权日:2006-06-16
标题 :Methods for synthesis of carotenoids, including analogs, derivatives, and synthetic and biological intermediates
发明人：LOCKWOOD SAMUEL F; TANG PENG CHO; NADOLSKI GEOFF; JACKSON HENRY L; FANG ZHIQIANG; DU YISHU; YANG MIN; GEISS WILLIAM; WILLIAMS RICHARD; BURDICK DAVID; BRAUN CRISTI L
权利人:LOCKWOOD SAMUEL F; TANG PENG CHO; NADOLSKI GEOFF; JACKSON HENRY L; FANG ZHIQIANG; DU YISHU; YANG MIN; GEISS WILLIAM; WILLIAMS RICHARD; BURDICK DAVID; BRAUN CRISTI L
摘要:A method for synthesizing intermediates for use in the synthesis of carotenoid synthetic intermediates, carotenoid analogs, and/or carotenoid derivatives. The carotenoid analog, derivative, or intermediate may be administered to a subject for the inhibition and/or amelioration of any disease that involves production of reactive oxygen species, reactive nitrogen species, radicals and/or non-radicals. In some embodiments, the invention may include methods for synthesizing chemical compounds including an analog or derivative of a carotenoid. Carotenoid analogs or derivatives may include acyclic end groups. In some embodiments, a carotenoid analog or derivative may include at least one substituent. The substituent may enhance the solubility of the carotenoid analog or derivative such that the carotenoid analog or derivative at least partially dissolves in water.

专利号:EP-0347163-A3
优先权日:1988-06-14
标题:Method for the synthesis of desferrioxamine B and analogs thereof, and intermediates
摘要:Disclosed is a synthesis of ndesferrioxamine B and analogs and homologs thereof nbeginning with the generation of the O-protected nN-(4-cyanobutyl)hydroxylamine which is acylated at the nO-benzylhydroxylamine nitrogen with either succinic or nacetic anhydride. The resulting half-acid amide or namide respectively, is subjected to a series of high nyield condensations and reductions which provide ndesferrioxamine B in 45% overall yield. Finally, a ndesamino analog of desferrioxamine is prepared in norder to demonstrate the synthetic utility of the nscheme as applied to desferrioxamine derivatives.

专利号:US-7074881-B2
优先权日:2001-02-06
标 题 :Methods of synthesis of polysuccinimide, copolymers of polysuccinimide and derivatives thereof
发明人：SWIFT GRAHAM; REDLICH GEORGE H
权利人:FOLIA INC
摘要:Disclosed are methods of synthesis of copoly(succinimide-aspartate), copolymers and derivatives thereof, prepared in a thermal or supercritical fluid method. Also disclosed are methods of isolating, compounding, stabilizing and processing the copoly(succinimide-aspartate), and its derivatives.

专利号:US-4987253-A
优先权日:1988-09-19
标 题 :Method for the synthesis of desferrioxamine B and analogs thereof
发明人：BERGERON RAYMOND J
权利人:UNIV FLORIDA
摘要:Disclosed is a synthesis of desferrioxamine B and analogs and homologs thereof beginning with the generation of the O-protected N-(4-cyanobutyl)hydroxylamine which is acylated at the O-benzylhydroxylamine nitrogen with either succinic or acetic anhydride. The resulting half-acid amide or amide respectively, is subjected to a series of high yield condensations and reductions which provide desferrioxamine B in 45% overall yield. Finally, a desamino analog of desferrioxamine is prepared in order to demonstrate the synthetic utility of the scheme as applied to desferrioxamine derivatives.

专利号:US-6919421-B2
优先权日:2001-02-06
标 题:Methods of synthesis of polysuccinimide, copolymers of polysuccinimide and derivatives thereof
发明人：SWIFT GRAHAM
权利人:FOLIA INC
摘要:Disclosed are methods of synthesis of polysuccinimide, copolymers, derivatives and blends with additives thereof, using a supercritical fluid. Also disclosed are methods of isolating, compounding, stabilizing and processing the polysucciminide, its copolymers and derivatives.