CAS: 92-86-4; 4',4-Dibromobiphenyl

• 英文名称4',4-Dibromobiphenyl
• 中文名称4,4'-二溴联苯
• IUPAC名称1-bromo-4-(4-bromophenyl)benzene
• 其它别名p,p'-Dibromobiphenyl
• CAS编号92-86-4
• MFCD编号:MFCD00000101
• EINECS号:202-198-6
• FDA UNII编号:POU26V2XT2
• 分子式:C12H8Br2
• 分子量:312.0
• 产品CID: 1967312
• 产品分类有机原料→分子砌块→芳环类化合物→苯类化合物

• 相似结构搜索
• InChIKey: HQJQYILBCQPYBI-UHFFFAOYSA-N
• InChI=1S/C12H8Br2/c13-11-5-1-9(2-6-11)10-3-7-12(14)8-4-10/h1-8H…
• 计算化学: 氢键受体数0.0氢键供体数0.0可旋转键数1.0

物理性质

• 熔点163-165°C
• 沸点355-360°C at 760 mmHg
• 闪点355-360°C
• 密度1.7243 (估算)
• PSA:0.0
• LogP:4.8786
• 折射率1.6000 (估算)
• 蒸汽压0.0000246 [mmHg]
• 溶解性Insoluble
• 外观形态白色至淡黄米色液体
• 储存条件密封, 常温干燥保存
• 产品应用用于合成有机中间体(医药,液晶).
• 性质描述单斜梭形结晶体或粉状,溶于苯,微溶于热乙醇,不溶于水.熔点166-169°C,沸点355-360°C

MSDS等安全信息

• GHS象形图
• GHS符号GHS08 & GHS07 & GHS05 & GHS09;
  注释: Health hazard & Exclamation mark & Corrosion & Environment
• 危险类别致癌性 类别2
  急性毒性 类别4(经口)
  特定目标器官毒性 - 单次接触 类别3
  皮肤腐蚀/刺激 类别2
  严重眼损伤 类别1
  水生急性毒性 类别1
  水生慢性毒性 类别1
  急性毒性 类别4(吸入)
  急性毒性 类别4(经皮)
• 警示词Danger(危险)
• 危险描述H351 |怀疑致癌.
  H302 |吞咽有害.
  H335 |可能引起呼吸道刺激.
  H315 |造成皮肤刺激.
  H318 |造成严重眼损伤.
  H400 |对水生生物毒性极大.
  H410 |对水生生物毒性极大并具有长期持续影响.
  H332 |吸入有害.
  H312 |皮肤接触有害.
• 防范说明P261-P264-P270-P271-P273-P280-P302+P352-P304+P340-P330-P362+P364-P391-P405-P501
• 危险等级9
• UN编号3152.0
• 危险品标志Xi,Xn,N
• 包装等级Ⅱ
• 安全声明37/39-26-37-36/37-61-60-39-36/37/39
• 危险类别码36/37/38-37/38-36-40-50/53-41-22-67-52/53
• WGK Germany1

欧盟法规

上下游产品

合成工艺路线路线简述

• 合成目标产物 4,4'-Dibromobiphenyl 主要起始原料 4-Bromophenylboronic Acid
• 5467-74-3 = 92-86-4
  反应条件:1.1 Reagents: Oxygen Catalysts: Cupric Acetate,Palladium Diacetate Solvents: Dimethyl Sulfoxide,Water; 14 H,Rt
  标题:"Benchtop" Biaryl Coupling Using Pd/cu Cocatalysis: Application To The Synthesis Of Conjugated Polymers
  作者:Minus,Matthew B.; Moor,Sarah R.; Pary,Fathima F.; Nirmani,L. P. T.; Chwatko,Malgorzata; Et Al
  参考文献:Organic Letters 日期:2021 卷标:23(8) 页码:2873-2877]
  
  5467-74-3 = 92-86-4
  反应条件:1.1 Reagents: Sodium Hydroxide Solvents: Water; 45 - 60 Min,120 - 130 °C
  标题:Organic Synthesis Via Magnetic Attraction: Benign And Sustainable Protocols Using Magnetic Nanoferrites
  作者:Nasir Baig,R. B.; Varma,Rajender S.
  参考文献:Green Chemistry 日期:2013 卷标:15(2) 页码:398-417]
  
  374564-35-9 = 92-86-4
  反应条件:1.1 Reagents: Oxygen Catalysts: Gold (Nanoclusters,Poly(N-Vinyl-2-Pyrrolidone) Supported) Solvents: Water; 24 H,Ph 6.86,320 K
  标题:Oxidative Homo-Coupling Of Potassium Aryltrifluoroborates Catalyzed By Gold Nanocluster Under Aerobic Conditions
  作者:Sakurai,Hidehiro; Tsunoyama,Hironori; Tsukuda,Tatsuya
  参考文献:Journal Of Organometallic Chemistry 日期:2007 卷标:692(1-3) 页码:368-374]
  
  28969-28-0 = 92-86-4
  反应条件:1.1 Reagents: Lithium Chloride Solvents: Hexamethylphosphoramide1.2 Catalysts: Rhodium,Tetracarbonyldi-μ-Chlorodi-1.3 Solvents: Water1.4 Solvents: Diethyl Ether,Benzene
  标题:Synthesis Of Symmetrical Biaryls Via Rhodium Catalyzed Dimerization Of Arylmercurials And Mechanism Of The Dimerization
  作者:Wang,Yu-Lan; Wu,Yang-Jie
  参考文献:Chemical Research In Chinese Universities 日期:2000 卷标:16(2) 页码:131-135]
  
  589-87-7 = 92-86-4
  反应条件:1.1 Reagents: Dl-Glucose Catalysts: Gold Triacetate Solvents: Tetrabutylammonium Acetate; 15 H,90 °C
  标题:Ullmann Homocoupling Catalysed By Gold Nanoparticles In Water And Ionic Liquid
  作者:Monopoli,Antonio; Cotugno,Pietro; Palazzo,Gerardo; Ditaranto,Nicoletta; Mariano,Bruno; Et Al
  参考文献:Advanced Synthesis & Catalysis 日期:2012 卷标:354(14-15) 页码:2777-2788]
  
  = 92-86-4
  反应条件:1.1 Reagents: Bromine; 40 Min,40 °C; 5 H,40 °C
  标题:Study Of Synthesis Technology Of 4,4'-Dibromobiphenyl
  作者:Wang,Yu-Jing; Yan,Xing-Li; Yuan,Li-Li; Wang,Hong-Ying; Li,Qin; Et Al
  参考文献:Hefei Gongye Daxue Xuebao 日期:2013 卷标:36(6) 页码:737-739]
  
  106-37-6 = 92-86-4
  反应条件:1.1 Reagents: Potassium Carbonate Catalysts: Palladium Solvents: Dimethylformamide; 20 H,110 °C
  标题:Palladium Nanoparticles Immobilized On The Magnetic Few Layer Graphene Support As A Highly Efficient Catalyst For Ligand Free Suzuki Cross Coupling And Homo Coupling Reactions
  作者:Rafiee,Fatemeh; Khavari,Parvaneh; Payami,Zahra; Ansari,Narges
  参考文献:Journal Of Organometallic Chemistry 日期:2019 卷标:883 页码:78-85]
  
  5467-74-3 = 92-86-4
  反应条件:1.1 Reagents: Sodium Carbonate Catalysts: Palladium Chloride Solvents: Water
  标题:Polydimethylsiloxane Thimbles
  作者:Long,Tyler R.; Bowden,Ned B.
  参考文献:E-Eros Encyclopedia Of Reagents For Organic Synthesis 日期:2011 卷标:1 页码:1-6]
  
  5467-74-3 = 92-86-4
  反应条件:1.1 Reagents: Cesium Carbonate Catalysts: Gold (Polystyrene-Co-Polymethacrylic Acid Microsphere-Supported) Solvents: N-Methyl-2-Pyrrolidone,Water; 43 H,110 °C
  标题:A Recyclable Au(I) Catalyst For Selective Homocoupling Of Arylboronic Acids: Significant Enhancement Of Nano-Surface Binding For Stability And Catalytic Activity
  作者:Zhang,Xin; Zhao,Haitao; Wang,Jianhui
  参考文献:Journal Of Nanoscience And Nanotechnology 日期:2010 卷标:10(8) 页码:5153-5160]
  
  374564-35-9 = 92-86-4
  反应条件:1.1 Reagents: Acetic Acid,Quinone,Tetrabutylammonium Tetrafluoroborate Catalysts: Palladium Diacetate Solvents: Dimethylformamide; 40 Min,80 °C
  标题:Pd(Oac)2/p-Benzoquinone-Catalyzed Anaerobic Electrooxidative Homocoupling Of Arylboronic Acids,Arylboronates And Aryltrifluoroborates In Dmf And/or Water
  作者:Amatore,Christian; Cammoun,Chama; Jutand,Anny
  参考文献:European Journal Of Organic Chemistry 日期:2008 卷标:(27) 页码:4567-4570]
  
  = 92-86-4
  反应条件:1.1 Reagents: N-Bromosuccinimide Catalysts: Silver Hexafluoroantimonate,9,10-Dihydro-9-(Methylthio)-9,10[1′,2′]-Benzenoanthracene Solvents: 1,2-Dichloroethane; 4 H,Rt
  标题:Triptycenyl Sulfide: A Practical And Active Catalyst For Electrophilic Aromatic Halogenation Using N-Halosuccinimides
  作者:Nishii,Yuji; Ikeda,Mitsuhiro; Hayashi,Yoshihiro; Kawauchi,Susumu; Miura,Masahiro
  参考文献:Journal Of The American Chemical Society 日期:2020 卷标:142(3) 页码:1621-1629]
  
  5467-74-3 = 92-86-4
  反应条件:1.1 Reagents: Oxygen Catalysts: Copper,Bis[μ-(1,10-Phenanthrolin-2-Olato-Kn1,Kn10:Ko2)]Di-,(Cu-Cu),Stereoisom... Solvents: Dimethylformamide; 20 H,Rt
  标题:Three-Coordinate Copper(I) 2-Hydroxy-1,10-Phenanthroline Dinuclear Complex Catalyzed Homocoupling Of Arylboronic Acids Towards Biphenyls Under Air Condition
  作者:Wang,Yan-Hong; Xu,Mei-Chen; Liu,Jie; Zhang,Ling-Juan; Zhang,Xian-Ming
  参考文献:Tetrahedron 日期:2015 卷标:71(52) 页码:9598-9601]
  
  = 92-86-4
  反应条件:1.1 Reagents: Sodium Bicarbonate,Silver Carbonate,Cuprous Iodide Catalysts: Triphenylphosphine,Palladium Diacetate Solvents: 1,4-Dioxane; 4 H,Reflux
  标题:Pd(Oac)2/pph3-Catalyzed Desulfonylative Homocoupling Of Arylsulfonyl Chlorides
  作者:Zhao,Qiao; Chen,Liangshun; Lang,Hongyue; Wu,Shengying; Wang,Limin
  参考文献:Chinese Journal Of Chemistry 日期:2015 卷标:33(5) 页码:535-538]
  
  5467-74-3 = 92-86-4
  反应条件:1.1 Reagents: Sodium Carbonate Catalysts: Tosyl Chloride,Palladium Chloride Solvents: Ethanol,Water
  标题:Ligandless Palladium Chloride-Catalyzed Homo-Coupling Of Arylboronic Acids In Aqueous Media
  作者:Kabalka,George W.; Wang,Lei
  参考文献:Tetrahedron Letters 日期:2002 卷标:43(16) 页码:3067-3068]
  
  5467-74-3 = 92-86-4
  反应条件:1.1 Reagents: Oxygen Catalysts: Palladium Diacetate Solvents: Water; 15 Min,Rt
  标题:Pd-Catalyzed Oxidative Homocoupling Of Arylboronic Acids In Wepa: A Sustainable Access To Symmetrical Biaryls Under Added Base And Ligand-Free Ambient Conditions
  作者:Appa,Rama Moorthy; Lakshmidevi,Jangam; Naidu,Bandameeda Ramesh; Venkateswarlu,Katta
  参考文献:Molecular Catalysis 日期:2021 卷标:501]
  
  589-21-9 = 92-86-4
  反应条件:1.1 Reagents: Sodium Acetate Catalysts: Palladium Diacetate Solvents: Methyl Ethyl Ketone; 3 H,50 °C
  标题:Method For Synthesizing Symmetric Biphenyl With Aromatic Hydrazine
  参考文献:China]
  
  589-87-7 = 92-86-4
  反应条件:1.1 Catalysts: Palladium,Bis(Acetonitrile)Dichloro-,[[2,2′-Bipyridine]-5,5′-Dicarboxylato(2-)-Ko5]Hydroxyaluminum Solvents: Dimethylformamide; 24 H,65 °C1.2 Reagents: Potassium Acetate Solvents: Ethanol,Dimethyl Sulfoxide; 14 H,120 °C
  标题:Immobilization Of Pd(Ii) On Mofs As A Highly Active Heterogeneous Catalyst For Suzuki-Miyaura And Ullmann-Type Coupling Reactions
  作者:Chen,Liyu; Gao,Zhiqiang; Li,Yingwei
  参考文献:Catalysis Today 日期:2015 卷标:245 页码:122-128]
  
  5467-74-3 = 92-86-4
  反应条件:1.1 Reagents: Potassium Carbonate Catalysts: Gold(1+),[2-[[[(1S)-2′-[[[5-(2-Aminoethyl)-3-(1,1-Dimethylethyl)-2-(Hydroxy-Ko)... (Mcm-41-Supported) Solvents: Xylene; 24 H,130 °C
  标题:Homogeneous And Heterogenized Au(Iii) Schiff Base-Complexes As Selective And General Catalysts For Self-Coupling Of Arylboronic Acids
  作者:Gonzalez-Arellano,C.; Corma,A.; Iglesias,M.; Sanchez,F.
  参考文献:Chemical Communications (Cambridge 日期:2005 卷标:(15) 页码:1990-1992]
  
  = 92-86-4
  反应条件:1.1 Reagents: Bromine Catalysts: Aluminum Chloride Solvents: Ethyl Acetate; 6 H,30 °C
  标题:Green Preparation Of 4-Alkyl-4'-Cyanobiphenyls
  参考文献:China]
  
  589-87-7 = 92-86-4
  反应条件:1.1 Reagents: Tripotassium Phosphate,Oxygen Catalysts: Gold Solvents: Dimethylformamide; 48 H,130 °C
  标题:Synthesis Of Dmf-Protected Au Nps With Different Size Distributions And Their Catalytic Performance In The Ullmann Homocoupling Of Aryl Iodides
  作者:Yao,Wang; Gong,Wei-Jie; Li,Hong-Xi; Li,Fei-Long; Gao,Jun; Et Al
  参考文献:Dalton Transactions 日期:2014 卷标:43(42) 页码:15752-15759

专利信息

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• ➥ 象形图和危险代码
• ➥ 防范代码详解
• ➥ 危险代码说明
• ➥ Globally Harmonized System
• ➥ REACH监管