三氟乙酸乙酯,L-赖氨酸盐酸盐置于乙醇,Sodium,溶剂黄146体系中,用 乙醇 用作溶剂,以62%的收率获得三氟乙酰赖氨酸 参考文献: Therapies For Cancer Using Isotopically Substituted Lysine[fr] Thérapies Contre Le Cancer Utilisant De La Lysine Substituée Isotopiquement 标题: Therapies For Cancer Using Isotopically Substituted Lysine[fr] Thérapies Contre Le Cancer Utilisant De La Lysine Substituée Isotopiquement 摘要:治疗癌症的方法和治疗用物质可能会使用或导致产生在自然界中不会出现的同位素修饰的赖氨酸.
专利号:US-9944609-B2 优先权日:2013-03-15 标 题:Formation of N-protected bis-3,6-(4-aminobutyl)-2, 5-diketopiperazine through a cyclic alpha-N-protected amino ester 发明人:FREEMAN JOHN J; PHANSTIEL OTTO; BAY WILLIAM ELLIOT; KRAFT KELLY SULLIVAN 权利人:MANNKIND CORP 摘要:A method for the synthesis of N-protected 3,6-aminoalkyl-2,5-diketopiperazines is provided. The method includes obtaining a cyclic α-N protected active amino ester and adding it to a mixture of an amine catalyst in an organic solvent.
专利号:US-2022243244-A1 优先权日:2019-10-10 标 题 :Compositions and methods for in vivo synthesis of unnatural polypeptides 发明人:ROMESBERG FLOYD E; FISCHER EMIL C; HASHIMOTO KOJI; FELDMAN AARON W; DIEN VIVIAN T; ZHANG YORKE 权利人:SCRIPPS RESEARCH INST 摘要:Disclosed herein are compositions, methods, and kits for a cell incorporating unnatural amino acids into an unnatural polypeptide. Also disclosed herein are compositions, methods, and kits for increasing activity and yield of the unnatural polypeptide synthesized by the cell.
专利号:WO-2021072167-A1 优先权日:2019-10-10 标 题:Compositions and methods for in vivo synthesis of unnatural polypeptides
专利号:US-2016304571-A1 优先权日:2010-03-24 标 题 :Synthesis of Site Specifically-Linked Ubiquitin
专利号:EP-4041249-A1 优先权日:2019-10-10 标题 :Compositions and methods for in vivo synthesis of unnatural polypeptides
专利号:US-2013065272-A1 优先权日:2010-03-24 标题 :Synthesis of Site Specifically-Linked Ubiquitin