专利号:US-8618281-B2 优先权日:2006-01-03 标 题 :Geometric synthesis of porphyrin rods 发明人:LINDSEY JONATHAN S; YU LIANHE; THAMYONGKIT PATCHANITA; BHISE ANIL D 权利人:LINDSEY JONATHAN S; YU LIANHE; THAMYONGKIT PATCHANITA; BHISE ANIL D; UNIV NORTH CAROLINA STATE 摘要:A method of making a compound of Formula I′ n ncomprises reacting a compound of the formula DLCHO, with a compound of the formulan n nto produce the compound of Formula I′. Methods of using the compounds are also described, particularly as intermediates for the synthesis of porphyrin rods, which porphyrin rods are in turn useful for (among other things) the production of molecular memory devices.
专利号:US-10919904-B2 优先权日:2016-08-17 标 题 :Northern-southern route to synthesis of bacteriochlorins 发明人:LIU YIZHOU; LINDSEY JONATHAN S; ALLU SRINIVASA RAO; FUJITA HIKARU 权利人:UNIV NORTH CAROLINA STATE 摘要:Described herein are chlorins, bacteriochlorins, methods and intermediates for the synthesis of bacteriochlorins, and methods of using such bacteriochlorins for, among other things, diagnostic and therapeutic purposes such as luminescent compounds in flow cytometry, and as active agents in photodynamic therapy (PDT).
专利号:US-2023286915-A1 优先权日:2020-10-07 标 题 :Synthesis of pyrrole acid derivatives 发明人:WILKINSON ANDREW; COOPER LAN; ORR DAVID; FINLAYSON JONATHAN; BUNT ADAM; KIRKHAM JAMES; LYTH DAVID; BLADES KEVIN 权利人:INFEX THERAPEUTICS LTD 摘要:This invention relates to the synthesis of compounds that can be used to treat bacterial infections in combination with other antibacterial agents, and more specifically in combination with a class of antibacterial agents known as carbapenems. The compounds resulting from the novel methods of the present invention are enzyme inhibitors and more particularly are metallo-β-lactamase inhibitors.
专利号:US-7741475-B2 优先权日:2006-02-13 标题:Synthesis of monovalent and polyvalent arabinans and mannose-capped arabinans of the protective cell-wall coat of mycobacterium tuberculosis 发明人:FRASER-REID BERTRAM; LU JUN 权利人:NATURAL PRODUCTS & GLYCOTECHNO 摘要:The present application provides arabinans and mannose-capped arabinan compositions of formulas I-VIII, described herein, and methods of making the compositions.
专利号:US-9822123-B2 优先权日:2005-02-18 标 题 :De novo synthesis of bacteriochlorins 发明人:KIM HAN-JE; LINDSEY JONATHAN S 权利人:UNIV NORTH CAROLINA STATE 摘要:A method of making a bacteriochlorin is carried out by condensing a pair of compounds of Formula II n nto produce the bacteriochlorin, wherein R is an acetal or aldehyde group. The condensing may be carried out in an organic solvent, preferably in the presence of an acid. The bacteriochlorins are useful for a variety of purposes such as active agents in photodynamic therapy, luminescent compounds in flow cytometry, solar cells, light harvesting arrays, and molecular memory devices.
专利号:US-8524892-B2 优先权日:2005-07-29 标题:Methods and intermediates for the synthesis of porphyrins 发明人:LINDSEY JONATHAN S; TANIGUCHI MASAHIKO; FAN DAZHONG 权利人:LINDSEY JONATHAN S; TANIGUCHI MASAHIKO; FAN DAZHONG; UNIV NORTH CAROLINA STATE 摘要:A method of making a porphyrin is carried out by: (a) condensing (i) a 1,9-bis(N,N-)dialkylaminomethyl)dipyrromethane of Formula II: n nwith (ii) a dipyrromethane to produce a reaction product; then (b) oxidizing the reaction product; and then (c) optionally demetallating said reaction product to produce the porphyrin. The reaction is particularly useful for making substituted porphyrins with a wide range of substituents at the A and/or B (the 5 and/or 15) positions.