硝基萘置于chromium(Vi) Oxide,五氯化磷,溶剂黄146体系中,化学反应生成3-氯苯酐 参考文献:Bogert; Boroschek,Journal Of The American Chemical Society,1901,Vol. 23,P. 751 标题:Bogert; Boroschek,Journal Of The American Chemical Society,1901,Vol. 23,P. 751
专利号:US-2017267706-A1 优先权日:2014-08-19 标 题:Method for the synthesis of heterocyclic hydrogen phosphine oxide 发明人:BRUYNEEL FREDERIC; NOTTE PATRICK PIERRE 权利人:STRAITMARK HOLDING AG 摘要:A method for the synthesis of a heterocyclic hydrogen phosphine oxide, having the general formula: n n n n n n n n n n wherein:n nR is a aliphatic or aromatic divalent group optionally including one or more heteroatoms and optionally having one or more substituents andn nX and Y are independently selected from —O—, —C(O)O— and —NR′—n nwherein R′ is a monovalent group optionally having one or more heteroatoms including the steps of:n na) forming a reaction mixture by mixing a compound having the general formula HX—R—YH and tetraphosphorus hexaoxide; andn nb) recovering the resulting compound comprising the heterocyclic hydrogen phosphine oxide.
专利号:US-9181237-B2 优先权日:2013-10-04 标 题 :Substituted berbines and their synthesis 发明人:GROTE CHRISTOPHER W 权利人:MALLINCKRODT LLC 摘要:The present invention provides substituted berbines, processes for the synthesis of substituted berbine compounds, as well as intermediates used in the synthesis of substituted berbine compounds. Also provided are methods for using the substituted berbines to inhibit cancer cell growth.
专利号:US-6096900-A 优先权日:1999-05-07 标 题 :Solventless preparation of phthalimides 发明人:NICK ROBERT JOSEPH; NELSON MARK ERIK; CARINGI JOSEPH JOHN; WILLIAMS DREW ELLIOT 权利人:GEN ELECTRIC 摘要:A method for the solventless synthesis of a phthalimide or phthalimide mixture is provided comprising contacting at least one amine reactant and at least one anhydride reactant in a solventless environment at a first temperature sufficient to allow the reactants to at least partially condense; and increasing the temperature to a second temperature sufficient to melt the reaction mixture, thereby allowing the reaction to go essentially to completion and form the reaction product.
专利号:US-11220480-B2 优先权日:2016-12-31 标题 :Synthesis of reactive intermediates for polyetherimides, and uses thereof 发明人:GUGGENHEIM THOMAS LINK; CHIONG HENDRICH; QUEVEDO SANCHEZ BERNABE; MISIEGO ARPA CARMEN ROCIO; RODRIGUEZ ORDONEZ JUAN JUSTINO; NIEVES REMACHA JAVIER 权利人:SHPP GLOBAL TECH BV 摘要:A method for producing a reactive intermediate composition, including: reacting a substituted phthalic anhydride of the formula (I) with a diamine of the formula H 2 N—R—NH 2 in the presence of an aromatic dianhydride in an amount of 10 to 50 mole percent based on the total moles of anhydride functionality in the reaction; wherein the reacting is conducted in an aprotic solvent in a reactor, under conditions effective to produce the reactive intermediate composition; and wherein X comprises a halogen or a nitro group, and R comprises a C 6-36 aromatic hydrocarbon group or a halogenated derivative thereof, a straight or branched chain C 2-20 alkylene or a halogenated derivative thereof, or a C 3-8 cycloalkylene or a halogenated derivative thereof.
专利号:US-6590108-B1 优先权日:2001-12-05 标题 :Methods for the preparation of dianhydrides 发明人:ODLE ROY RAY; GUGGENHEIM THOMAS LINK; SWATOS WILLIAM JAMES; VOLLMER MICHAEL J 权利人:GEN ELECTRIC 摘要:A method for the synthesis of a dianhydride comprises transimidation of bis (imide) (IV) n in the presence of a substituted phthalic anhydride or 4-substituted tetrahydrophthalic anhydride to yield dianhydride (V)
专利号:US-6657068-B2 优先权日:2002-03-22 标题:Liquid phase oxidation of halogenated ortho-xylenes 发明人:COLBORN ROBERT EDGAR; HALL DAVID BRUCE; KOCH PETER; OECKEL GERALD 权利人:GEN ELECTRIC 摘要:A method for the manufacture of halophthalic acid by liquid phase oxidation of halo-ortho-xylene is disclosed. The halophthalic acid may be dehydrated to form halophthalic anhydride which is useful in the synthesis of polyetherimide.
参考文献:10.1007/s10895-005-0016-1 摘要:Ge FY, Yan XL, Yan FY, Pan HY, Chen LG. New fluorescent labels: 4- and 7-chlorofluorescein. J Fluoresc. 2005 Nov;15(6):829–33. doi: 10.1007/s10895-005-0016-1.