CAS: 129940-50-7; (S)-2-((Trityloxy)Methyl)Oxirane

相似化合物

65291-30-7 57044-25-4 60456-23-7

上下游产品

CAS号76-83-5 三苯基氯甲烷 | CAS号57044-25-4 (|R|)-(+)-缩水甘油 | CAS号60456-23-7 (S)-缩水甘油 | CAS号65291-30-7 三苯甲基-(R)-缩水甘油醚 | CAS号124-38-9 二氧化碳 | CAS号203250-06-0 (R)-3-chloro-1-... | CAS号596-31-6 甲氧基三苯基甲烷 | CAS号170277-79-9 (3S)-3-(2-hydro... | CAS号170277-82-4 (2S)-1-tritylox... | CAS号170277-77-7 (3S)-3-[2-(MESY...

(R)-3-Chloro-1-O-Trityl-1,2-Propanediol置于氢氧化钾体系中,用 乙醇 用作溶剂,以1.48 Kg的收率获得三苯甲基-(S)-缩水甘油醚
参考文献:Macrocyclic Bisindolylmaleimides: Synthesis By Inter-And Intramolecular Alkylation
标题:Macrocyclic Bisindolylmaleimides: Synthesis By Inter-And Intramolecular Alkylation
摘要:Macrocyclic Bisindolylmaleimides 1-4 Have Been Identified As Competitive Reversible Inhibitors Of Pkc Beta(1) And Beta(2) And Are Being Advanced To The Clinic For Evaluation As A Treatment Of Retinopathy Associated With Diabetic Complications. Highly Convergent And Stereoselective Syntheses Of 1-4 Have Been Developed. The Key Synthetic Step Involves Intermolecular Alkylation Of Symmetrical Bisindolylmaleimide 9 With Chiral Bisalkylating Agent 8C And Is Amenable To The Preparation Of Multikilogram Quantities Of These Compounds. The Synthetic Sequence To 1,The Most Active Compound,Proceeds In 11 Steps And 26% Overall Yield (>98% Ee) From (R)-1-Chloro-2,3-Propanediol. No Chromatographic Purifications Are Required Throughout The Process And The Final Product Is Isolated In >97% Purity After Crystallization From Dmf/meoh. Synthesis Of 1-4 By Intramolecular Alkylation Proved Less Efficient,Requiring 1 Steps And Affording 1-4 In Lower Overall Yields Of 6.0-8.5%.
Doi:10.1021/jo971980H

专利信息

专利号:US-5591852-A
优先权日:1990-08-10
标题 :Process for the preparation of nucleotides
发明人：VEMISHETTI PURUSHOTHAM; BRODFUEHRER PAUL R; HOWELL HENRY G; SAPINO JR CHESTER
权利人:ACAD OF SCIENCE CZECH REPUBLIC; REGA STICHTING
摘要:The present invention relates to a novel and economical process for the synthesis of HPMP-substituted nucleotide antiviral compounds. Also disclosed are novel intermediates produced in the process for the preparation of HPMPC.

专利号:US-9862687-B2
优先权日:2013-11-15
标题:Morphic forms of hexadecyloxypropyl-phosphonate esters and methods of synthesis thereof
发明人：WARE JR ROY WENDELL; DOWNEY AARON LEIGH
权利人:CHIMERIX INC; CHIMERIX INC
摘要:The disclosure describes methods of synthesis of phosphonate ester compounds. The methods according to the disclosure allow for large-scale preparation of phosphonate ester compounds having high purity and stability. Also disclosed are morphic forms of phosphonate ester compounds.

专利号:US-2019016687-A1
优先权日:2013-11-15
标 题:Morphic forms of hexadecyloxypropyl-phosphonate esters and methods of synthesis thereof

专利号:US-11912667-B2
优先权日:2013-11-15
标 题:Morphic forms of hexadecyloxypropyl-phosphonate esters and methods of synthesis thereof

专利号:US-8962829-B1
优先权日:2013-11-15
标 题 :Morphic forms of hexadecyloxypropyl-phosphonate esters and methods of synthesis thereof

专利号:US-10112909-B2
优先权日:2013-11-15
标题 :Morphic forms of hexadecyloxypropyl-phosphonate esters and methods of synthesis thereof