专利号:WO-2024222082-A1 优先权日:2023-04-28 标 题 :Amino acid-derived ceramide, synthesis method therefor and use thereof 发明人:YANG CHAOWEN; YE LIU; LIU LIANGXIAN 权利人:SHENZHEN DIKEMAN BIOTECHNOLOGY CO LTD 摘要:An amino acid-derived ceramide, having a structure of general formula I or an isomer of general formula I: (I), wherein M is R 3 or (II), and the R 1 is a residue after condensation of a polypeptide; the R 3 is selected from alanine, threonine, proline, asparagine, glutamine, leucine, tryptophan, serine, valine, methionine, tyrosine, histidine, L-aspartic acid-4-tert-butyl ester, L-aspartic acid-1-tert-butyl ester, glycine, isoleucine, phenylalanine, lysine, arginine, cysteine, L-glutamic acid-5-tert-butyl ester, L-glutamic acid-1-tert-butyl ester, or a residue after condensation of a polypeptide; the polypeptide is formed by condensation of 2-10 amino acids; R 2 is selected from one of the following structures: -C 15 H 29 , -C 15 H 31 , -C 15 H 27 , -CHOHC 14 H 27 , and -CHOHC 14 H 29 . The compound exhibits excellent effects in moisturizing, anti-oxidation, anti-glycation, skin barrier repair, tissue healing, etc.
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1: Reddon AR, O'Connor CM, Marsh-Rollo SE, Balshine S, Gozdowska M, Kulczykowska E. Brain nonapeptide levels are related to social status and affiliative behaviour in a cooperatively breeding cichlid fish. R Soc Open Sci. 2015 Feb 4;2(2):140072. doi: 10.1098/rsos.140072. eCollection 2015 Feb. 2: Lema SC, Sanders KE, Walti KA. Arginine vasotocin, isotocin and nonapeptide receptor gene expression link to social status and aggression in sex-dependent patterns. J Neuroendocrinol. 2015 Feb;27(2):142-57. doi: 10.1111/jne.12239. 4: Zabłocka A, Mitkiewicz M, Macała J, Janusz M. Neurotrophic Activity of Cultured Cell Line U87 is Up-Regulated by Proline-Rich Polypeptide Complex and Its Constituent Nonapeptide. Cell Mol Neurobiol. 2015 Oct;35(7):977-86. doi: 10.1007/s10571-015-0192-8. Epub 2015 Apr 5.
合成参考文献
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