CAS: 179552-74-0; N-(3-Chloro-4-Fluorophenyl)-7-Methoxy-6-Nitroquinazolin-4-Amine

上下游产品

7-氯-N-(3-氯-4-氟苯基)-6-硝基-4-氨基喹唑啉 7-Chloro-N-(3-Chloro-4-Fluorophenyl)-6-Nitroquinazolin-4-Amine 179552-73-9
N-(3-氯-4-氟苯基)-7-氟-6-硝基-4-喹唑啉胺 N-(3-Chloro-4-Fluorophenyl)-7-Fluoro-6-Nitroquinazolin-4-Amine 162012-67-1
4-氯-7-甲氧基-6-硝基喹唑啉-4(3H)-酮 4-Chloro-7-Methoxy-6-Nitroquinazoline 55496-69-0
7-甲氧基-6-硝基喹唑啉-4(3H)-酮 7-Methoxy-6-Nitroquinazolin-4(3H)-One 1012057-47-4

7-氯-N-(3-氯-4-氟苯基)-6-硝基-4-氨基喹唑啉置于sodium Methylate体系中,用 溶剂黄146,二甲基亚砜 用作溶剂,化学反应生成N-(3-氯-4-氟苯基)-7-甲氧基-6-硝基喹唑啉-4-胺
参考文献:4-Anilinoquinazoline Derivatives Bearing A Heteroaryl Substituted At The
标题:4-Anilinoquinazoline Derivatives Bearing A Heteroaryl Substituted At The
摘要:这项发明涉及式i的4-苯胺基喹唑啉衍生物 其中m为1或2;每个r.Sup.1包括氢,卤代,(1-4C)烷基和(1-4C)烷氧基;N为1,2或3;每个r.Sup.2包括氢,羟基,卤代和(1-4C)烷基;Ar为含有最多四个氮杂原子的5-或9-成员氮链杂芳基团,或ar为含有最多三个氮杂原子的5-,6-,9-或10-成员氮链不饱和杂环基团,其带有一个或两个从氧代和硫代氧代中选择的取代基,如2-氧代-4-咪唑啉-1-基;或其药学上可接受的盐;它们的制备方法,含有它们的药物组合物,以及在治疗增生性疾病如癌症中利用这些化合物的受体酪氨酸激酶抑制性能.

专利信息

专利号:WO-2023098592-A1
优先权日:2021-11-30
标题:Preparation method for carbon-loaded iron-based catalyst and use thereof in synthesis of intermediates of anti-cancer inhibitors

专利号:CN-114315595-B
优先权日:2021-11-30
标题 :Preparation method of a carbon-supported iron-based catalyst and its application in the synthesis of anti-cancer inhibitor intermediates

专利号:CN-114315595-A
优先权日:2021-11-30
标题:Preparation method of carbon-supported iron-based catalyst and synthesis application of anti-cancer inhibitor intermediate thereof