CAS: 2905-23-9; 2-Chlorobenzenesulfonyl Chloride

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CAS号3900-89-8 2-氯苯基硼酸 | CAS号95-51-2 2-氯苯胺 | CAS号17333-83-4 显色基艳黄 R | CAS号111711-69-4 1-(2-chlorophen... | CAS号31121-19-4 2,2'-二氯二苯二硫醚 | CAS号3320-83-0 2-氯苯基异氰酸酯 | CAS号27886-58-4 2-氯-苯磺酸 | CAS号6961-82-6 邻氯苯磺酰胺 | CAS号15946-36-8 2-氯苯亚磺酸钠 | CAS号100-61-8 N-甲基苯胺 | CAS号6320-03-2 2-氯苯硫酚 | CAS号17260-67-2 2-氯-N-甲基苯磺酰胺 | CAS号64900-69-2 1-(2-chlorophen...

2-Chlorophenyldiazonium Tetrafluoroborate置于氯化亚砜,Tris(Bipyridine)Ruthenium(II) Dichloride Hexahydrate体系中,用 水,乙腈 用作溶剂,化学反应 20.0H,以85%的收率获得2-氯苯磺酰氯
参考文献:光氧化还原催化芳族磺酰化
标题:光氧化还原催化芳族磺酰化
摘要:可见光的光氧化还原催化能够从苯胺高效合成芳磺酰氯.新方案涉及方便地原位制备苯二氮杂鎓盐(来自苯胺)和反应性气体so 2和hcl(来自socl 2水溶液).光催化的氯磺酰化反应可在温和的条件下(室温,乙腈/水)以较低的催化剂负载量进行.容许各种官能团(例如卤化物,叠氮化物,硝基,Cf 3,Sf 5,酯,杂芳烃).理论和实验研究都支持光氧化还原催化机制.
Doi:10.1002/cssc.201601293

专利信息

专利号:US-5618944-A
优先权日:1993-05-05
标题:Method for the synthesis of anthrapyrazolones
发明人：ZHANG LIN-HUA; AUERBACH JOSEPH
权利人:DU PONT MERCK PHARMA
摘要:This invention relates to compounds, including 5-chloro-2-[2-[[(4-methylphenyl)sulfonyl]oxy]ethyl]-7-[2,4,6-trimethylphenyl)methoxy]anthra[1,9-cd]pyrazol-6(2H)-one and analogs thereof, which are useful as intermediates for the synthesis of anthrapyrazolone anticancer agents, including losoxantrone. This invention also relates to methods for the synthesis of anthrapyrazolone anticancer agents, including losoxantrone.

专利号:US-6288297-B1
优先权日:1998-10-01
标 题:Process for the preparation of cyclopropylacetylene
发明人：WANG ZHE; YIN JIANGUO; FORTUNAK JOSEPH M; CAMPAGNA SILVIO
权利人:DU PONT PHARM CO
摘要:The present invention relates generally to novel methods for the synthesis of cyclopropylacetylene which is an essential reagent in the asymmetric synthesis of (S)-6-chloro-4-cyclopropylethynyl-4-trifluoromethyl-1,4-dihydro-2H-3,1-benzoxazin-2-one; a useful human immunodeficiency virus (HIV) reverse transcriptase inhibitor. In the process, for example, cyclopropane carboxaldehyde is alkylated to form 1,1,1-trichloro-2-cyclopropyl-ethanol; which in turn is hydroxy protected to form 1,1,1-trichloro-2-cyclopropylethyltosylate; which in turn undergoes elimination to form cyclopropyl acetylene. This improvement provides for high conversion of inexpensive, readily available starting materials into cyclopropylacetylene, high overall yields and can be conducted on an industrial scale.

专利号:US-6048991-A
优先权日:1990-11-16
标题:Preparation of epoxides
发明人：HAERMELING DIETER
权利人:BASF AG
摘要:Alpha-hydroxy-epoxides of alpha-alkoxy-epoxides of the formula IV ##STR1## in which the substituents have the following meanings: R 7 , R 8 , R 9 , R 10 , R 11 are independently hydrogen, C 1 -C 20 -alkyl, C 3 -C 12 -cycloalkyl, C 4 -C 20 -cycloalkylalkyl, C 1 -C 20 -hydroxy-alkyl, a heterocyclic ring, or an aryl or C 7 -C 20 -arylalkyl group optionally substituted by C 1 -C 8 -alkyl, C 1 -C 8 -alkoxy, halogen, C 1 -C 4 -haloalkyl, C 1 -C 4 -halo-alkoxy, phenyl, phenoxy, halophenyl, halophenoxy, carboxy, C 2 -C 8 -alkoxycarbonyl, or cyano, or R 7 and R 8 or R 7 and R 9 or R 7 and R 10 or R 9 and R 10 or R 10 and R 11 together form a (CH 2 ) n group in which n is an integer from 1 to 10 and which may be optionally substituted by C 1 -C 8 -alkyl, C 1 -C 8 -alkoxy, and/or halogen, and n R 12 is hydrogen, C 1 -C 8 -alkyl, or benzyl, n provided that R 10 is not hydrogen, methyl, ethyl, propyl, or cyclohexyl when R 7 , R 8 , R 9 , or R 11 is hydrogen, that R 7 is not methyl when R 8 is methyl or phenyl and R 9 , R 10 , or R 11 is hydrogen, that R 7 is not methyl when R 8 , R 9 , R 10 , or R 11 is hydrogen and R 12 is ethyl, that R 7 is not phenyl or hexyl when R 8 , R 9 , R 10 , or R 11 is hydrogen, that R 9 is not methyl when R 7 , R 8 , R 10 , or R 11 is hydrogen, that R 10 and R 11 are not methyl when R 7 , R 8 , or R 9 is hydrogen, and that R 7 and R 10 do not together form an unsubstituted cycloalkyl when R 8 , R 9 , or R 11 is hydrogen. The epoxides of the above formula serve as intermediates for the synthesis of, inter alia, perfumes, plant protectants and polymers.

专利号:US-6359164-B1
优先权日:1998-10-01
标 题:Process for the preparation of cyclopropylacetylene
发明人：WANG ZHE; FORTUNAK JOSEPH M
摘要:The present invention relates generally to novel methods for the preparation of cyclopropylacetylene which is an essential reagent in the asymmetric synthesis of (S)-6-chloro-4-cyclopropylethynyl-4-trifluoromethyl-1,4-dihydro-2H-3,1-benzoxazin-2-one; a useful human immunodeficiency virus (HIV) reverse transcriptase inhibitor with superior anti-retroviral activity. In the process, for example, cyclopropane carboxaldehyde is alkylated to form 1,1,1-trichloro-2-cyclopropyl-ethanol; which in turn undergoes elimination to form 1,1-dichloro-2-cyclopropyl-ethene; which in turn undergoes elimination to form cyclopropyl acetylene.

专利号:US-2010204463-A1
优先权日:2007-08-07
标题 :Preparation Of Synthetic Nucleosides via Pi-Allyl Transition Metal Complex Formation
发明人：LIOTTA DENNIS C; LI YONGFENG
权利人:LIOTTA DENNIS C; LI YONGFENG
摘要:This invention provides highly regioselective and stereoselective processes for preparing synthetic nucleosides. A process for the preparation of synthetic nucleosides is provided that comprises a) preparing a bicycloamide derivative, b) reacting the bicycloamide derivative with a nucleic acid base or heterocyclic base or salt thereof in the presence of a transition metal catalyst to form a cyclopentenecarboxamide, and c) cleaving a carboxamide group from the cyclopentenecarboxamide to form the synthetic nucleoside. The processes according to the invention can be used for the synthesis of a variety of anti-viral agents, including Abacavir, Carbovir, and Entecavir, as well as derivatives thereof.

专利号:US-2024050916-A1
优先权日:2020-12-14
标题:Biodegradable microcapsules based on composite material and synthesis process
发明人：VRHUNEC ALJOSA; STEFANEC DEJAN; KOTNIK TOMAZ; KRANJC DOMEN
权利人:MIKROCAPS D O O
摘要:The present invention relates to biodegradable microcapsules with a membrane formed of a biodegradable composite material and their synthesis. Biodegradable microcapsules obtained as described in the present invention consist of a core material comprising at least one liquid water-immiscible active component, and a membrane that encloses this core material, the membrane consisting of a composite material comprising a carrier polymer framework and at least one filler deposited into the pores of said carrier polymer framework and deposited onto the surface of said carrier polymer framework, wherein the carrier polymer framework is made of at least one polymer and the filler is a lipophilic biodegradable organic compound which is solid at room temperature and has a melting point above 40° C. The thickness of the membrane is between 20 and 200 nm and the microcapsule diameter is between 1 and 50 pm. Biodegradable microcapsules as described in the present invention are used in the form of aqueous dispersions as additives to fabric softeners, detergents, pesticides, pharmaceutical ingredients, paints, cosmetics products and the like.