CAS: 4295-99-2; 4-Cyanotetrahydro-4H-Pyran

相似化合物

5337-03-1 344329-76-6 50675-18-8

上下游产品

CAS号29943-42-8 四氢吡喃酮 | CAS号38622-91-2 4-toluene-sulfo... | CAS号344329-76-6 4-甲酰胺基吡喃 | CAS号177703-80-9 2-(benzylsulfon... | CAS号243661-09-8 2-(o-tolylsulfo... | CAS号1768-64-5 4-氯四氢-2H-吡喃 | CAS号2942-58-7 氰代磷酸二乙酯 | CAS号50675-18-8 四氢吡喃-4-甲醛 | CAS号52748-35-3 tetrahydro-pyra... | CAS号50675-18-8 四氢吡喃-4-甲醛 | CAS号130290-79-8 4-氨甲基四氢吡喃 | CAS号137052-08-5 1-(四氢-2H-吡喃-4-基)乙酮 | CAS号7403-84-1 Hydrazinecarbox... | CAS号7403-99-8 [1-(oxan-4-yl)h... | CAS号7464-18-8 1-(四氢-2H-吡喃-4-基... | CAS号7502-01-4 [[4-methyl-1-(o... | CAS号856255-87-3 4-甲基四氢-2H-吡喃-4-甲腈 | CAS号65626-24-6 (4-甲基四氢-2H-吡喃-4-基)甲胺

四氢吡喃酮置于sodium Tetrahydroborate,二甲基十二/十四烷基叔胺,碘体系中,用 四氢呋喃,二氯甲烷 作为反应溶剂,化学反应 7.0H,反应生成 4-氰基四氢吡喃
参考文献:一种4-氰基四氢吡喃的制备方法
标题:一种4-氰基四氢吡喃的制备方法
摘要:本发明公开了一种4‑氰基四氢吡喃的制备方法,包括以下步骤:步骤一,无水无氧操作下,于500Ml三口瓶中,加入无水四氢呋喃120Ml,加入100G的四氢吡喃‑4‑酮,加催化量的碘,冰水浴控温10oc以下滴加37G的硼氢化钠,加完后升至室温搅拌反应5H小时,反应完毕;冰水浴下控温10oc以下,向反应液中滴加饱和氯化铵水溶液30Ml,继续搅拌半小时,过滤反应液,四氢呋喃洗涤滤饼,过滤后旋干溶液得到粗品,经减压蒸馏后得到89G产率为90%的四氢吡喃‑4‑醇纯品;步骤二,将100G四氢吡喃‑4‑醇,150Gn,N‑二甲基二乙胺加入装有二氯甲烷的三口瓶.本药物中间体4‑氰基四氢吡喃的制备方法以廉价的四氢吡喃‑4‑酮为原料,原料便宜易得稳定,反应过程温和,产率高,分离纯化简单.

专利信息

专利号:WO-2020118597-A1
优先权日:2018-12-13
标 题 :Process for making 1- [ (3r, 4s) -4-cyanotetrahydropyran-3-yl] -3- [ (2-fluoro-6-methoxy-4-pyridyl) amino] pyrazole-4-carboxamide
发明人：CHASSAING CHRISTOPHE PIERRE ALAIN; YIN JINGJUN; CLEATOR EDWARD; SONG LICHEN; XIAO WENSONG; DAHMEN THOMAS; SALANTA DANIEL; SCHEIPERS CLAUDIA; SCHMITT HARALD
权利人:INTERVET INT BV; INTERVET INC; CHASSAING CHRISTOPHE PIERRE ALAIN; YIN JINGJUN; CLEATOR EDWARD; SONG LICHEN; XIAO WENSONG; DAHMEN THOMAS; SALANTA DANIEL; SCHEIPERS CLAUDIA; SCHMITT HARALD
摘要:New processes for the preparation of 1- [ (3R, 4S) -4-cyanotetrahydropyran-3-yl] -3- [ (2-fluoro-6-methoxy-4-pyridyl) amino] pyrazole-4-carboxamide (I) which include (i) novel more efficient synthesis for bromo and iodo pyridine intermediates, (ii) synthesis of a novel pyrazole ester intermediate which can be obtained in enantiopure form and (iii) the combination of these intermediates into compound (I).

专利号:US-11999741-B2
优先权日:2017-05-26
标 题:Process for the synthesis of 6-((3S,4S)-4-methyl-1-(pyrimidin-2-ylmethyl)pyrrolidin-3-yl)-3-(tetrahydropyran-4-yl-7H-imidazo[1,5-a]pyrazin-8-one
发明人：SVENSTRUP NIELS; ZHANG JUN; SUN JIKUI; CHEN YUYIN; KONG JIANSHE; MA RUJIAN; ZHANG JUNHUA; QIN LIANG; XIAO HUANMING; SUN JINXU; MENG XIAO; SUN FENGLAI; ZHU JINGYANG
权利人:CARDURION PHARMACEUTICALS INC
摘要:The present disclosure relates to processes for preparing 64(3s,4s)-4-methyl-1-(pyrimidin-2-ylmethyl)pyrrolidin-3-yl)-3-(tetrahydropyran-4-yl-7h-imidazo[1,5-a]pyrazin-8-one.

专利号:US-2025019381-A1
优先权日:2017-05-26
标题 :PROCESS FOR THE SYNTHESIS OF 6-((3S,4S)-4-METHYL-1-(PYRIMIDIN-2-YLMETHYL)PYRROLIDIN-3-YL)-3-(TETRAHYDROPYRAN-4-YL-7H-IMIDAZO[1,5-a]PYRAZIN-8-ONE

专利号:CN-108689976-A
优先权日:2018-07-23
标 题:Catalytic Synthesis of 4-Iodotetrahydropyran Derivatives Catalyzed by 5-Sulphosalicylic Acid and Titanocene Dichloride

专利号:CN-102993144-A
优先权日:2012-12-07
标 题 :One-pot synthesis of 4-aminotetrahydropyran

专利号:CN-108689976-B
优先权日:2018-07-23
标题 :A method for the synthesis of 4-iodotetrahydropyran derivatives catalyzed by 5-sulfosalicylic acid in conjunction with dichlorotitanocene