CAS: 452092-31-8; Ethyl 1-Cyclopropyl-6,7-Difluoro-8-Hydroxy-4-Oxo-1,4-Dihydroquinoline-3-Carboxylate

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1-cyclopropyl-6,7-difluoro-8-hydroxy-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid ethanol 8-benzyloxy-1-cyclopropyl-6,7-difluoro-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate ethyl 1-cyclopropyl-6,7-difluoro-8-difluoromethoxyl-1,4-dihydro-4-oxo quinoline-3-carboxylate 8-((S)-1-benzyl-4-methylene-piperidin-2-ylmethoxy)-1-cyclopropyl-6,7-difluoro-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester ethyl 8-(2-((2S,4R)-1-(benzyloxycarbonyl)-4-(tert-butyldimethylsilyloxy)pyrrolidin-2-yl)ethoxy)-1-cyclopropyl-6,7-difluoro-4-oxo-1,4-dihydroquinoline-3-carboxylate ethyl 7-((2S,4R)-4-benzyloxycarbonylamino-2-(hydroxymethyl)pyrrolidin-1-yl)-1-cyclopropyl-6-fluoro-8-fomyl-4-oxo-1,4-dihydroquinoline-3-carboxylate

Ethyl 8-(Benzyloxy)-1-Cyclopropyl-6,7-Difluoro-1,4-Dihydro-4-Oxoquinoline-3-Carboxylate置于palladium(II) Hydroxide 氢气体系中,用 四氢呋喃,乙醇 作为反应溶剂,化学反应 2.0H,反应生成 1-环丙基-6,7-二氟-1,4-二氢-8-羟基-4-氧代-3-喹啉羧酸乙酯
参考文献:Novel Antibacterial Compounds
标题:Novel Antibacterial Compounds
摘要:该发明涉及一种新型嵌合抗生素,其化学式为i,其中r1为ch2Nhcor5,杂环烷基甲基,杂环氧甲基或杂环氨基甲基;r2为h,Oh,Oso3H,Opo3H2,och2Opo3H2,ococh2Ch2Cooh,ocor6;r3为h或卤素;r4为(c1-C3)烷基,(c1-C3)卤代烷基或环烷基;r5为烷基或卤代烷基;r6为天然氨基酸残基或二甲氨基甘氨酸残基.这些嵌合化合物在制造治疗感染(例如细菌感染)的药物中非常有用.