CAS: 5460-31-1; 2-Methyl-3-Nitrophenol

上下游产品

CAS号603-83-8 2-甲基-3-硝基苯胺 | CAS号95-48-7 邻甲酚 | CAS号606-20-2 2,6-二硝基甲苯 | CAS号18102-30-2 2-甲氧基-3-甲基苯胺 | CAS号143359-98-2 acetic acid-(2-... | CAS号861548-37-0 acetic acid-(2-... | CAS号861609-40-7 2-methoxy-3-met... | CAS号7664-93-9 硫酸 | CAS号53967-73-0 2-甲氧基-6-硝基苯甲酸 | CAS号53222-92-7 2-甲基-3-氨基苯酚 | CAS号50868-74-1 3-甲氧基-2-甲基乙酰苯胺 | CAS号4837-90-5 4-甲氧基吲哚 | CAS号4837-88-1 2-甲基-3-硝基苯甲醚 | CAS号21420-58-6 bae°Cystin | CAS号19689-86-2 PARA-NITROBENZY... | CAS号20876-27-1 (2-甲氧基-6-硝基苯基)乙腈 | CAS号20876-37-3 1-苄氧基-2-甲基-3-硝基苯 | CAS号53600-33-2 2-氨基-6-甲氧基苯甲酸

2,6-二硝基甲苯置于乙醇,硫酸,硫化氢,水,Sodium Nitrite体系中,化学反应生成 2-甲基-3-硝基苯酚
参考文献:Noelting,Chemische Berichte,1904,Vol. 37,P. 1021
标题:Noelting,Chemische Berichte,1904,Vol. 37,P. 1021

专利信息

专利号:US-7589170-B1
优先权日:1998-09-25
标题 :Synthesis of cyclic peptides
发明人：SMYTHE MARK LESLIE; MEUTERMANS WIM DENIS FRANS; BOURNE GREGORY THOMAS; MCGEARY ROSS PETER
权利人:UNIV QUEENSLAND
摘要:This invention relates to methods for preparing cyclic peptides and peptidomimetic compounds in solution and bound to solid supports, and to cyclic peptide or peptidomimetic libraries for use in drug screening programs. In particular, the invention relates to a generic strategy for synthesis of cyclic peptides or peptidomimetics that enables the efficient synthesis under mild conditions of a wide variety of desired compounds. Two approaches were evaluated for their improvements in solution and solid phase synthesis of small cyclic peptides: positioning reversible N-amide substituents in the sequence; and applying native ligation chemistry in an intramolecular sense. Systematic investigation of the effects of preorganising peptides prior to cyclisation by using peptide cyclisation auxiliaries, and developing new linkers and peptide cyclisation auxiliaries to aid cyclic peptide synthesis gives surprising improvements in both yields and purity of products compared to the prior art methods. The combination of these technologies provides a powerful generic approach for the solution and solid phase synthesis of small cyclic peptides. The ring contraction and N-amide substitution technology of the invention provide improved methods for the synthesis of cyclic peptides and peptidomimetics. When used in conjunction with linker strategies, this combination provides solid-phase avenues to cyclic peptides and peptidomimetics.

专利号:US-5820764-A
优先权日:1993-12-31
标题:Treatment/removal of byproduct aqueous effluents comprising hydroxynitro-aromatic compounds
发明人：JOULAK FAOUZI; LE BRIS LOUIS; MARION PHILIPPE
权利人:RHONE POULENC CHIMIE
摘要:Objectionable byproduct aqueous effluents containing contaminating amounts of hydroxynitroaromatic compounds, in particular those aqueous effluents produced during the synthesis of nitroaromatic compounds, e.g., dinitrotoluenes, via reaction of an aromatic compound with nitric acid in the presence of sulfuric acid, are efficiently, facilely and economically treated/removed by (a) intimately contacting a mixture of at least one nitroaromatic compound and at least one hydroxynitroaromatic compound with an aqueous wash medium containing a neutralizing agent, (b) separating the resulting admixture into an organic phase and an aqueous phase, (c) recycling a fraction of the separated aqueous phase to the aqueous wash medium to thus constitute a portion thereof, and (d) periodically draining a fraction of the wash medium, whether to destruction thereof or to waste.

专利号:US-4764263-A
优先权日:1987-05-18
标 题:Electrochemical synthesis of substituted aromatic amines in basic media
发明人：GREGORY THOMAS D; STUTTS KENNETH J
权利人:DOW CHEMICAL CO
摘要:Substituted amino aromatic compounds such as 3-amino-4-hydroxybenzoic acid are prepared by electrolytically reducing the corresponding nitro aromatic compound in a basic medium at temperatures below 60° C. and current densities greater than 50 milliamps per square centimeter. The aminohydroxybenzoic acids are useful in the preparation of polybenzoxazoles which are used to make fibers and composites having high strength and thermal stability.

专利号:WO-0144185-A1
优先权日:1999-12-16
标题 :Carbon monoxide-based synthesis of spla2 inhibitors
发明人：SAWYER JASON SCOTT
权利人:LILLY CO ELI; SAWYER JASON SCOTT
摘要:A method of making a compound, comprises reacting a compound represented by formula (I), with CO and a catalyst, to form the compound of formula (II); where formula (I) is and, formula (II) is and where R2 is selected from the group consisting of R20 -OR20, -SR20, -NR20R20'and -C(O)R20; R3, R4, R5, R6 and R7 are each individually selected from the group consisting of H, halogen, R, -OR, -SR, -NRR', -C(O)R, -C(O)OR, -S(O)R and -S(O)2R; provided that at least one of R4 and R5 is not H; each R and R20 is individually selected from the group consisting of alkyl, alkenyl, alkynyl, aryl and heterocyclic radical; and each R' and R20' is individually selected from the group consisting of H, alkyl, alkenyl, alkynyl, aryl and heterocyclic radical. The method provides an alternative route to indole-3-glyoxylamide compounds.

专利号:US-7718598-B1
优先权日:1998-09-25
标 题:Auxiliary for amide bond formation
发明人：SMYTHE MARK LESLIE; MEUTERMANS WIM DENIS FRANS
权利人:UNIV QUEENSLAND
摘要:This invention relates to methods for preparing cyclic peptides and peptidomimetic compounds in solution and bound to solid supports, and to cyclic peptide or peptidomimetic libraries for use in drug screening programmes. In particular, the invention relates to a generic strategy for synthesis of cyclic peptides or peptidomimetics that enables the efficient synthesis under mild conditions of a wide variety of desired compounds. Two approaches were evaluated for their improvements in solution and solid phase synthesis of small cyclic peptides: positioning reversible N-amide substituents in the sequence; and applying native ligation chemistry in an intramolecular sense. Systematic investigation of the effects of preorganizing peptides prior to cyclisation by using peptide cyclisation auxiliaries, and developing new linkers and peptide cyclisation auxiliaries to aid cyclic peptide synthesis gives surprising improvements in both yields and purity of products compared to the prior art methods. The combination of these technologies provides a powerful generic approach for the solution and solid phase synthesis of small cyclic peptides. The ring contraction and N-amide substitution technology of the invention provide improved methods for the synthesis of cyclic peptides and peptidomimetics. When used in conjunction with linker strategies, this combination provides solid-phase avenues to cyclic peptides and peptidomimetics.

专利号:US-5262546-A
优先权日:1992-11-17
标 题:Process for the preparation of 5,6-diacetoxyindole
发明人：PAN YUH-GOO; LIM MU-ILL
权利人:CLAIROL INC
摘要:An indole of the formula ##STR1## wherein R 5 and R 6 are acetoxy or hydrogen, at least one of R 5 and R 6 being acetoxy, is prepared, in good yield, in a one pot synthesis, without extraction, recrystallization or isolation of intermediate reaction product; A compound of the formula ##STR2## wherein R 1 and R 2 are benzyloxy or hydrogen, provided that at least one of R 1 and R 2 is benzyloxy, is subjected to reductive cyclization followed by acetylation of the resultant reaction product.