CAS: 874-05-5; 1H-Indazol-3-Amine

该化合物是有机化合物,其特点是由五人组成的环组成,内含两个氮原子;该化合物的特性是附于该环第三个位置的氨基组(-NH2),有助于该环的再活性和潜在的生物活动;该化合物一般是白色的,是白色的,是白色的,在水和酒精等极溶剂中溶解,便于其在各种化学反应和应用中使用. 1H-Indazol-3-amine对医药化学具有兴趣,因为它有可能成为药物的构件,特别是针对各种生物路径的化合物的开发,其特性,包括熔点,沸点和光谱特性,可因纯度和环境条件而不同而不同.与许多含氮的外生循环一样,它可能表现出有趣的电子特性,从而便于在各种化学反应和应用中使用. 1H-Indazol-3-amine, 因为它是医学的一个课题,因为它是有机合成和材料科学的研究对象.

结构式图片

欧盟法规

ECHA物质C&L通报

上下游产品

CAS号394-47-8 2-氟苯甲腈 | CAS号166118-78-1 3-(2-Aminopheny... | CAS号7727-37-9 氮气 | CAS号1219024-53-9 2-[2-(diphenylm... | CAS号1339956-01-2 benzhydrylidene... | CAS号408322-07-6 3-amino-1-benzy... | CAS号185011-16-9 1-amino-3-nitro... | CAS号82215-92-7 N-(1H-indazol-3... | CAS号108552-93-8 N-(3-morpholin-... | CAS号108552-99-4 1-PROPYL-1H-IND... | CAS号41339-17-7 3-氨基-5-硝基吲唑 | CAS号90-16-4 3,4-二氢-4-氧-1,2,... | CAS号2596-89-6 3H-Indazol-3-im... | CAS号28519-78-0 1-苄基-1H-吲唑-3-胺 | CAS号271-44-3 吲唑 | CAS号7664-41-7 氨 | CAS号60301-20-4 1-甲基-1H-吲唑-3-胺 | CAS号100476-97-9 3-(1H-indazol-3...

合成工艺路线路线简述

  • 408322-07-6 = 874-05-5
    反应条件:1.1 Reagents: Hydrochloric Acid Solvents: Water
    标题:Synthesis And Oxidation Of 1,3-Diamino- And 1-Amino-3-Azidoindazoles
    作者:Dyablo,O. V.; Pozharskii,A. F.; Kuz'Menko,V. V.; Kolesnichenko,M. A.
    参考文献:Chemistry Of Heterocyclic Compounds (New York 日期:2001 卷标:37(5) 页码:567-573]

    394-47-8 = 874-05-5
    反应条件:1.1 Reagents: Hydrazine Hydrate (1:1) Solvents: 1-Butanol; Rt -> Reflux; 18 H,Reflux
    标题:Synthesis And Structure-Activity Relationships Of Indazole Arylsulfonamides As Allosteric Cc-Chemokine Receptor 4 (Ccr4) Antagonists
    作者:Procopiou,Panayiotis A.; Barrett,John W.; Barton,Nicholas P.; Begg,Malcolm; Clapham,David; Et Al
    参考文献:Journal Of Medicinal Chemistry 日期:2013 卷标:56(5) 页码:1946-1960]

    1219024-53-9 = 874-05-5
    反应条件:1.1 Reagents: P-Toluenesulfonic Acid Solvents: Methanol; Overnight,Reflux
    标题:Two-Step Synthesis Of Substituted 3-Aminoindazoles From 2-Bromobenzonitriles
    作者:Lefebvre,Valerie; Cailly,Thomas; Fabis,Frederic; Rault,Sylvain
    参考文献:Journal Of Organic Chemistry 日期:2010 卷标:75(8) 页码:2730-2732]

    394-47-8 = 874-05-5
    反应条件:1.1 Reagents: Hydrazine Hydrate (1:1) Solvents: 1-Butanol; 7 H,Reflux
    标题:3-[(Imidazolidin-2-Yl)Imino]Indazole Ligands With Selectivity For The α2-Adrenoceptor Compared To The Imidazoline I1 Receptor
    作者:Saczewski,Franciszek; Kornicka,Anita; Hudson,Alan L.; Laird,Shayna; Scheinin,Mika; Et Al
    参考文献:Bioorganic & Medicinal Chemistry 日期:2011 卷标:19(1) 页码:321-329
2-Azidophenylamidine Hydrochloride 以 邻二氯苯 作为反应溶剂,化学反应 0.5H,以0.03 G的收率获得产物3-氨基吲唑
参考文献:Ardakani,Manouchehr Azadi; Smalley,Robert K.; Smith,Richard H.,Journal Of The Chemical Society. Perkin Transactions I,1983,# 10,P. 2501-2506
标题:Ardakani,Manouchehr Azadi; Smalley,Robert K.; Smith,Richard H.,Journal Of The Chemical Society. Perkin Transactions I,1983,# 10,P. 2501-2506

海关参考信息

专利信息


专利号:WO-9410327-A1
优先权日:1992-10-28
标 题 :Enzymatic synthesis of polyaniline
发明人:ZEMEL HAYA; QUINN JOHN F
权利人:ALLIED SIGNAL INC
摘要:This invention relates to a process for the enzymatic synthesis of electrically conductive substituted and unsubstituted polyanilines. Aniline monomer(s), an oxidizing agent, which comprises an enzyme and an electron acceptor, and an acidifying agent are reacted together to form polyanilines.

专利号:US-5420237-A
优先权日:1991-08-29
标 题:Enzymatic synthesis of polyaniline
发明人:ZEMEL HAYA; QUINN JOHN F
权利人:ALLIED SIGNAL INC
摘要:This invention relates to a process for the enzymatic synthesis of electrically conductive substituted and unsubstituted polyanilines. Aniline monomer(s), an oxidizing agent, which comprises an enzyme and an electron acceptor, and an acidifying agent are reacted together to form polyanilines.

专利号:US-2025289827-A1
优先权日:2022-12-02
标 题:Morphic forms of a mutant braf degrader and methods of manufacture thereof
发明人:YU ROBERT T; HE MINSHENG; SCHNADERBECK MATTHEW J; KREGER BRIDGET; POLLOCK ROY MACFARLANE; JIANG SIYI; LI MEIQI; CHEN BOLU; LU JIANNAN
权利人:C4 THERAPEUTICS INC
摘要:Advantageous isolated morphic forms of (3R)-3-[6-[2-cyano-3-[[ethyl(methyl)sulfamoyl]amino]-6-fluorophenoxy]-4-oxoquinazolin-3-yl]-8-[2-[1-[3-(2,4-dioxo-1,3-diazinan-1-yl)-5-fluoro-1-methylindazol-6-yl]-4-hydroxypiperidin-4-yl]acetyl]-1-oxa-8-azaspiro[4.5]decane (Compound 1), which is a mutant BRAF degrader, and methods to prepare Compound 1 morphic forms for therapeutic applications are provided in the invention. The invention also provides improved methods for the synthesis of Compound 1, new pharmaceutical compositions comprising Compound 1, and new uses of Compound 1.

专利号:US-7019094-B2
优先权日:2002-05-31
标 题:Intermediate products, methods for their preparation and use thereof
发明人:WESTMAN JACOB; LUNDIN RONNY
权利人:BIOTAGE AB
摘要:Novel solid supported intermediate products of the general formula n ncoupled to a solid polymeric support through one or both of the R 1 groups or through the R 4 group which are suitable for synthesis of heterocyclic compounds are disclosed. Methods for preparing such intermediate products are also disclosed and also the use of the intermediate products in simple and fast methods on solid phase for synthesis of heterocycles.

专利号:US-4257942-A
优先权日:1977-10-06
标题:New water-insoluble azo dyes
发明人:DEFEO FRANCESCO; CIPOLLI ROBERTO
权利人:ACNA
摘要:The present invention relates to the synthesis of new dyes having the following general formula: wherein: D is the residue of a diazotizable component of the carbocyclic or heterocyclic series X is an ethylene group, optionally substituted by halogen-methyl, alkyl C1-C4, aryl, aralkyl or CH2OCO(HN)nR (wherein R and n have the meanings hereinafter defined); R is alkyl C1-C8 optionally substituted by halogen, CN,COOH; aryl optionally substituted by one or more atoms of halogen, alkyl C1-C4, alkoxyl C1-C4; alkoxyl C1-C4; alkoxyl C1-C8; Aryloxy; aralkoxy; cycloalkoxy; aralkyl; naphthyl optionally substituted by halogen; alkenyl C2-C8, optionally substituted by halogen, CN, COOH; R1 and R2, either like or unlike each other, may be alkyl C1-C4 optionally substituted by halogen or CN groups; aralkyl; R3 is H; halogen, alkyl C1-C4; alkoxyl C1-C4, optionally substituted. n is 0 or 1.

专利号:JP-2010222357-A
优先权日:2002-03-11
标题 :Intermediate compounds for the synthesis of aminoindazole derivatives
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合成参考文献


参考文献:10.3797/scipharm.1102-08
摘要:Gupta M, Dureja H, Madan AK. Models for the prediction of receptor tyrosine kinase inhibitory activity of substituted 3-aminoindazole analogues. Sci Pharm. 2011 Apr;79(2):239–57.
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