CAS: 93106-60-6; 1-Cyclopropyl-7-(4-Ethylpiperazin-1-yl)-6-Fluoro-4-Oxo-1,4-Dihydroquinoline-3-Carboxylic Acid

• 英文名称1-Cyclopropyl-7-(4-Ethylpiperazin-1-yl)-6-Fluoro-4-Oxo-1,4-Dihydroquinoline-3-Carboxylic Acid
• 中文名称恩诺沙星
• IUPAC名称1-cyclopropyl-7-(4-ethylpiperazin-1-yl)-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
• 其它别名Enrofloxacin (Usan:Usp:Inn:Ban); Enrofloxacin Flavored Tablets; Norguaiaretic Acid, Dihydro-; 1-Cyclopropyl-7-(4-Ethyl-1-Piperazinyl)-6-Fluoro-1,4-Dihydro-4-Oxo-3-Quinolinecarboxylic Acid; Enromed
• CAS编号93106-60-6
• MFCD编号:MFCD00792463
• EINECS号:618-911-2
• FDA UNII编号:3DX3XEK1BN
• 分子式:C19H22FN3O3
• 分子量:359.4
• 产品CID: 1969768
• 同类组份化合物CAS93106-59-3 (HCl)93106-60-6 (free base)
• 产品分类原料药 → 抗生素类药物 → 其它抗生素类药

• 相似结构搜索
• 产品信息参考;
• InChIKey: SPFYMRJSYKOXGV-UHFFFAOYSA-N
• InChI=1S/C19H22FN3O3/c1-2-21-5-7-22(8-6-21)17-10-16-13(9-15(17)20)18(24)14(19(25)26)11-23(16)12-3-4-12/h9-12H,2-8H2,1H3,(H,25,26)…
• 计算化学: 氢键受体数7.0氢键供体数1.0可旋转键数4.0

物理性质

• 熔点225 °C
• 沸点560.5±50.0 °C at 760 mmHg
• 闪点292.8±30.1 °C
• 密度1.4±0.1 g/cm3
• pKa:6.43±0.41(预测)
• PSA:65.78
• LogP:1.88
• 折射率1.634
• 蒸汽压0.0±1.6 mmHg at 25°C
• 溶解性Chloroform (Slightly), Methanol (Very Slightly, Heated)
• 敏感性按规定使用和贮存的不会分解，避光、潮湿
• 外观形态淡黄色至浅米色粉末或晶体
• 储存条件密封干燥,2-8°C
• 产品应用抗菌,适用细菌和支原体感染
• 性质描述该品属第三代喹诺酮类抗菌药,为专用兽药,是一种类白色或微黄色结晶性针状粉末,熔点221-226°C,无臭;无味.常用其盐酸盐;乳酸盐;钠盐.该品在酸性或碱性条件下溶解,在二甲基甲酰胺;氯仿中略溶,甲醇中微溶,水中不溶.该品长时间光照色泽加深.在相对湿度较高的地方贮藏,易吸潮结块.

MSDS等安全信息

• GHS象形图
• GHS符号GHS07 & GHS08;
  注释: Exclamation mark & Health hazard
• 危险类别急性毒性 类别4(经口)
  呼吸道致敏 类别1
  皮肤致敏 类别1
  生殖毒性 类别2
  特定目标器官毒性-重复接触 类别1
  水生急性毒性 类别1
  水生慢性毒性 类别1
  水生慢性毒性 类别2
  水生慢性毒性 类别3
  严重眼损伤 类别1
  急性毒性 类别4(经皮)
  严重眼刺激 类别2
• 警示词Danger(危险)
• 危险描述H302 |吞咽有害.
  H334 |吸入可能引起过敏或哮喘症状或呼吸困难.
  H317 |可能引起皮肤过敏反应.
  H361 |怀疑对生育能力或胎儿造成损害.
  H372 |长期或反复接触损害器官.
  H400 |对水生生物毒性极大.
  H410 |对水生生物毒性极大并具有长期持续影响.
  H411 |对水生生物有毒并具有长期持续影响.
  H361f |怀疑会影响生育能力.
  H412 |对水生生物有害并具有长期持续影响.
  H318 |造成严重眼损伤.
  H312 |皮肤接触有害.
  H319 |造成严重眼刺激.
• 防范说明P261-P264-P270-P280-P301+P312-P302+P352
• UN编号NONH for all modes of transport
• 危险品标志Xi
• 安全声明26-36/37-24/25
• 危险类别码36/37/38
• WGK Germany3

欧盟法规

上下游产品

合成工艺路线路线简述

• 合成目标产物 Enrofloxacin 主要起始原料 1-Ethylpiperazine And 7-Chloro-1-Cyclopropyl-6-Fluoro-1,4-Dihydro-4-Oxoquinoline-3-Carboxylic Acid
• 5308-25-8 + 86393-33-1 = 93106-60-6
  反应条件:1.1 Catalysts: Molybdate(42-),Triacontakis[μ-(Acetato-Ko:Ko′)]Doheptacontaaquaoctacontahecta-μ... Solvents: Water; 30 Min,Reflux
  标题:Fast And Green Method To Synthesis Of Quinolone Carboxylic Acid Derivatives Using Giant-Ball Nanoporous Isopolyoxomolybdate As Highly Efficient Recyclable Catalyst In Refluxing Water
  作者:Mirzaie,Yahya; Lari,Jalil; Vahedi,Hooshang; Hakimi,Mohammad; Nakhaei,Ahmad; Et Al
  参考文献:Journal Of The Mexican Chemical Society 日期:2017 卷标:61(1) 页码:35-40]
  
  85721-33-1 = 93106-60-6
  反应条件:1.1 Reagents: Triethylamine Solvents: Dimethylformamide; Rt -> 80 °C; 2 H,80 °C1.2 Reagents: Water; Cooled
  标题:Synthesis Of Labeled Enrofloxacin-D5
  作者:Xu,Zhong-Jie; Lu,Wei-Jing; Lu,Hao
  参考文献:Jingxi Huagong 日期:2012 卷标:29(11) 页码:1050-1052]
  
  5308-25-8 + 86393-33-1 = 93106-60-6
  反应条件:1.1 25 Min,150 °C
  标题:Conventional And Microwave-Assisted Synthesis Of Quinolone Carboxylic Acid Derivatives
  作者:Mirzaie,Y.; Lari,J.; Vahedi,H.; Hakimi,M.
  参考文献:Russian Journal Of General Chemistry 日期:2016 卷标:86(12) 页码:2865-2869]
  
  105392-26-5 + 5308-25-8 = 93106-60-6
  反应条件:1.1 Reagents: Sodium Hydroxide Solvents: Toluene; 4 H,Reflux1.2 Reagents: Hydrochloric Acid Solvents: Water1.3 Solvents: Water; 1 H,Reflux; 14 H,115 °C
  标题:Convenient One Pot Synthesis Of Some Fluoroquinolones In Aqueous Media
  作者:Abaee,M. Saeed; Sharifi,Ruhollah; Borhani,Shahin; Heravi,Majid M.; Motahari,Hossein
  参考文献:Heterocyclic Communications 日期:2005 卷标:11(5) 页码:415-418]
  
  93107-08-5 = 93106-60-6
  反应条件:1.1 Reagents: Diisopropylethylamine Catalysts: Potassium Iodide Solvents: Acetonitrile,Water; 0 °C; 16 H,Rt
  标题:Pharmacological Characterization Of 7-(4-(Piperazin-1-Yl)) Ciprofloxacin Derivatives: Antibacterial Activity,Cellular Accumulation,Susceptibility To Efflux Transporters,And Intracellular Activity
  作者:Marquez,Beatrice; Pourcelle,Vincent; Vallet,Coralie M.; Mingeot-Leclercq,Marie-Paule; Tulkens,Paul M.; Et Al
  参考文献:Pharmaceutical Research 日期:2014 卷标:31(5) 页码:1290-1301]
  
  107884-20-8 = 93106-60-6
  反应条件:1.1 Reagents: Sodium Hydroxide Solvents: Water1.2 Reagents: Acetic Acid
  标题:An Improved Process For The Preparation Of Quinolone Derivatives,E.G. Ciprofloxacin
  参考文献:World Intellectual Property Organization]
  
  = 93106-60-6 [标题:Reaction Conditions
  标题:Preparation Of Specific Conjugation Bridge Linkers And Immunoconjugates And Methods Of Using Them
  参考文献:World Intellectual Property Organization]
  
  = 93106-60-6 [标题:Reaction Conditions
  标题:Preparation Of Bridge Linkers Used For Specific Conjugation Of A Cytotoxic Agent To A Cell-Binding Molecule
  参考文献:World Intellectual Property Organization]
  
  5308-25-8 + 86393-33-1 = 93106-60-6
  反应条件:1.1 Catalysts: Zirconium Dioxide (Sulfonic Acid Derivative Absorbed On Ferrite) Solvents: Water; 19 Min,Reflux
  标题:Nano-Fe3O4@zro2-So3H As Highly Efficient Recyclable Catalyst For The Green Synthesis Of Fluoroquinolones
  作者:Nakhaei,Ahmad; Ramezani,Shirin; Shams-Najafi,Sayyed Jalal; Farsinejad,Sadaf
  参考文献:Letters In Organic Chemistry 日期:2018 卷标:15(9) 页码:739-746]
  
  5308-25-8 + 86393-33-1 = 93106-60-6
  反应条件:1.1 Catalysts: Aluminum Bromide Solvents: Ethanol; 4 H,Rt -> 75 °C1.2 Reagents: Sodium Hydroxide Solvents: Water; 30 Min,70 °C1.3 Reagents: Hydrochloric Acid Solvents: Water; Neutralized
  标题:Preparation Of Norfloxacin,Ciprofloxacin And Enrofloxacin
  参考文献:China]
  
  5308-25-8 = 93106-60-6
  反应条件:1.1 Catalysts: Aluminum Chloride Solvents: Isoamyl Alcohol; 8 H,140 °C1.2 Reagents: Hydrochloric Acid Solvents: Water1.3 Reagents: Hydroxide; Ph 7.2 - 7.3
  标题:Methods For Preparation Of Norfloxacin,Ciprofloxacin And Enrofloxacin
  参考文献:China]
  
  5308-25-8 + 86393-33-1 = 93106-60-6
  反应条件:1.1 Catalysts: Cerium Trichloride Heptahydrate Solvents: Water; Rt -> 100 °C; 10 H,99 °C1.2 Reagents: Methanol; 0.5 H,Reflux; Reflux -> 5 °C; 1 H,5 - 8 °C
  标题:Process For Preparation Of Carbostyril Medicines
  参考文献:China]
  
  98349-25-8 + 5308-25-8 = 93106-60-6
  反应条件:1.1 Reagents: Potassium Carbonate Solvents: Water; 10 H,90 - 95 °C; 90 °C -> Rt1.2 Reagents: Hydrochloric Acid Solvents: Water; 3 H,Ph 7.5,Rt
  标题:Process For The Preparation Of Fluoroquinolone-3-Carboxylic Acids Via Amination Of Alkyl Fluoro(Haloquinolone)Carboxylates With Amines
  参考文献:France]
  
  5308-25-8 + 86483-53-6 = 93106-60-6
  反应条件:1.1 Reagents: Potassium Carbonate Solvents: Dimethylformamide; 2 H,120 °C1.2 Reagents: Acetic Acid,Hydrochloric Acid Solvents: Water; 4 H,90 °C1.3 Solvents: Isoamyl Alcohol; 6 H,110 - 115 °C
  标题:Synthesis Of Derivatives Of 1-Ethyl-6-Fluoro-7-(1-Piperazinyl)-1,4-Dihydro-4-Oxo-Quinoline-3-Carboxylic Acid
  作者:Xie,Jiangang; Liao,Xincheng; Qu,Lingbo; Tian,Mengchao
  参考文献:Zhengzhou Daxue Xuebao 日期:2003 卷标:35(3) 页码:75-78]
  
  5308-25-8 + 86393-33-1 = 93106-60-6 [标题:Reaction Conditions
  标题:New Process For The Preparation Of 1-Cyclopropyl-3-Quinolinecarboxylic Acid Derivatives
  参考文献:Spain]
  
  5308-25-8 + 86393-33-1 = 93106-60-6
  反应条件:1.1 Solvents: Dimethyl Sulfoxide
  标题:Cycloaracylation Of Enamines. I. Synthesis Of 4-Quinolone-3-Carboxylic Acids
  作者:Grohe,Klaus; Heitzer,Helmut
  参考文献:Liebigs Annalen Der Chemie 日期:1987 卷标:(1) 页码:29-37]
  
  = 93106-60-6 [标题:Reaction Conditions
  标题:Preparation Of Bridge Linkers Used For Specific Conjugation Of Two Or More Cytotoxic Agents To A Cell-Binding Molecule
  参考文献:World Intellectual Property Organization]
  
  = 93106-60-6 [标题:Reaction Conditions
  标题:Preparation Of Novel Bridge Linkers Containing An Acetylenedicarbonyl Group For Specific Conjugation Of A Cytotoxic Agent To A Cell-Binding Molecule
  参考文献:World Intellectual Property Organization]
  
  = 93106-60-6 [标题:Reaction Conditions
  标题:Preparation Of Hydrophilic Linkers For The Conjugation Of A Cytotoxic Agent Or A Chromophore To A Cell-Binding Molecule
  参考文献:World Intellectual Property Organization

海关参考信息

• 2905110000-甲醇
  2912110000-甲醛
  2915110000-甲酸
  2921211000-乙二胺
• 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
• 详情请参考：📖 海关编码查询和海关进出口税则

专利信息

其他信息查阅

• ➥ 象形图和危险代码
• ➥ 防范代码详解
• ➥ 危险代码说明
• ➥ Globally Harmonized System
• ➥ REACH监管