CAS: 118-52-5; 1,3-Dichloro-5,5-Dimethylimidazolidine-2,4-Dione

上下游产品

5,5-dimethyl-imidazolidine-2,4-dione sodium cyanide acetone (1-Cyan-1-methylethyl)harnstoff 4-chloro-1,2-dihydro-1,5-dimethyl-2-phenyl-3H-pyrazol-3-one 1-chloro-2-methoxynaphthalene ethyl-(1-chloro-[2]naphthyl)-ether 2,5-dimethoxybenzyl chloride

5,5-二甲基海因置于次氯酸叔丁酯体系中,用 甲醇 用作溶剂,以95.4 %的收率获得1,3-二氯-5,5-二甲基海因
参考文献:黄原酸酯衍生化试剂及其制备方法与应用
标题:黄原酸酯衍生化试剂及其制备方法与应用
摘要:本发明公开黄原酸酯衍生化试剂的制备方法,以酰胺或者磺酰胺为原料,经过氯化后,与黄原酸金属盐进行亲核取代反应,即可制备得到亲电型的还原酸酯衍生化试剂,具体如下:(1)向酰胺或者磺酰胺中加入第一溶剂,搅拌,再加入次氯酸叔丁酯,在20‑40oc下反应5‑60Min后,将反应混合物过滤,干燥,得到中间产物n‑氯酰胺或n‑氯磺酰胺;(2)向黄原酸金属盐中加入第二溶剂,搅拌,得到黄原酸金属盐溶液,再将所述n‑氯酰胺或n‑氯磺酰胺用第二溶剂溶解,然后滴加入黄原酸金属盐溶液中,在10‑40oc下反应4‑20H,即可得到相应的黄原酸酯衍生化试剂.所述黄原酸酯衍生化试剂为新型试剂,适用底物范围广,反应条件温和.

专利信息

专利号:US-2020087149-A1
优先权日:2015-07-22
标 题 :Method for the synthesis of nanofluids
发明人：TALAEI ZEINAB; RASHIDI ALIMORAD; AMROLLAHI BIYOUKI AZADEH; MAHJOUB ALLREZA; LOTFI ROGHAYYEH; RASHTCHI MARYAM
权利人:RES INSTITUTE OF PETROLEUM INDUSTRY
摘要:The present invention relates to a method for the synthesis of nanofluids including functionalization of carbon nanostructures through a new method comprising the addition of carbon nanostructures to water; ultrasonication of the solution; addition of persulfate salt and one or several metal hydroxides of the first column of the periodic table to the aqueous solution containing carbon nanostructure; re-exposing the solution to ultrasonic waves; and then, the separation of the functionalized carbon nanostructures from the solution and washing the carbon nanostructures with water to neutralize them and mixing the nanoparticles obtained from the previous step with the fluid. By presenting a new method for the synthesis of the functionalized carbon nanostructures with specific amount of functional groups and their application in the synthesis of nanofluids, an increase in the stability and thermal conductivity of nanofluids takes place.

专利号:US-11479577-B2
优先权日:2016-05-18
标题:Intermediates for the synthesis of bile acid derivatives, in particular of obeticholic acid
发明人：WEYMOUTH-WILSON ALEXANDER; KOMSTA ZOFIA; WALLIS LAURA; EVANS TIMOTHY; DAVIES IEUAN; OTTER CARL; BATCHELOR RHYS
权利人:NZP UK LTD
摘要:The present invention relates to compounds which are intermediates in the synthesis of bile acid derivatives with pharmacological activity. The invention relates to compounds of general formula (I):wherein:, R1, R2, R3, R4, R5, R6 and Y are as defined herein.The compounds are intermediates in the synthesis of synthetic bile acids which are useful in the treatment of conditions such as liver disease. In addition, the invention relates to a method of synthesizing these intermediates and a method of preparing obeticholic acid and obeticholic acid analogues from the compounds of the invention.

专利号:US-8975340-B2
优先权日:2010-12-15
标题 :Synthesis of sequestration resins for water treatment in light water reactors
发明人：YENGOYAN LEON; FRATTINI PAUL L; WELLS DANIEL MORGAN
权利人:YENGOYAN LEON; FRATTINI PAUL L; WELLS DANIEL MORGAN; ELECTRIC POWER RES INST
摘要:An organic synthesis of materials to achieve removal of low molecular weight ionic species, such as transition metal ions including cobalt, iron, nickel, and zinc, from aqueous solutions. The synthesis includes the steps of providing a cation exchange resin, functionalizing the cation exchange resin using a chloride intermediate to form a sulfonyl chloride resin, and reacting a multi-amine based ligand with the sulfonyl chloride resin to form a sequestration resin. The synthesis further includes the steps of cooling the sequestration resin, and washing and drying the sequestration resin.

专利号:US-4609707-A
优先权日:1983-11-10
标题 :Synthesis of polymers containing integral antibodies
发明人：NOWINSKI ROBERT C; HOFFMAN ALLAN S
权利人:GENETIC SYSTEMS CORP
摘要:A method is disclosed for the de novo synthesis of antibody-containing polymers and the preparation of a class of polymerizable compounds used in the synthesis of such antibody-containing polymers. Antibody-containing polymers formed from monomer/antibody conjugates and nonderivatized polymerizable compounds can be varied in formation of the polymer to provide control of (a) molecular spacing, steric accessibility and the number of antibody molecules that are integrally incorporated into the polymer backbone, and (b) the chemical and physical structure of the polymer itself, thus enabling specific tailoring of antibody-containing polymers for particular end-use application. Also disclosed is a method for the selective removal of a compound from a solution or suspension thereof using monomer/receptor conjugates where the compound has the capacity to bind to the receptor in the conjugate. The bound compound is removed by polymerization - induced separation of the monomer/receptor--compound complex from solution.

专利号:US-6201120-B1
优先权日:1997-11-20
标题:Synthesis of 11-aryl-5,6-dihydro-11H-dibenz[b,e]azepines
发明人：MOUSSA ADEL M; LOMBARDY RICHARD J; HAIDER REEM M; SUN MINGHUA
权利人:PHARM ECO LAB INC
摘要:Disclosed is a three step synthesis of 11-aryl-5,6-dihydro-11H-dibenz[b,e]azepines from a 2-aminobenzophenone represented by the following structural formula:and a starting material represented by the following structural formula:Phenyl Ring A, Phenyl Ring B and Phenyl Ring C are independently unsubstituted or substituted with one, two or three substituents. Each substituent on Phenyl Ring A, Phenyl Ring B and Phenyl Ring C is independently chosen.R is -H, a aliphatic group, a substituted aliphatic group, an aryl group, a substituted aryl group, -C(O)-R', -C(O)-H, -C(O)-NHR', -S(O)2R', -C(O)-C(O)-R', -C(O)-C(O)-H, -C(S)-R', -C(S)-H, -C(O)-OR', -C(S)-OR', -C(O)-SR', -C(S)-SR', -C(O)-NR'2 or -C(O)-C(S)-R'. R' is an aliphatic group, a substituted aliphatic group, an aryl group or a substituted aryl group.R1 is a leaving group.The present invention also includes novel compounds which are intermediates in the preparation of 11-aryl-5,6-dihydro-11H-dibenz[b,e]azepines.

专利号:US-2020079715-A1
优先权日:2018-09-06
标题 :2-position modification for synthesis of resorcinol scaffolding
发明人：DAVIS ROBERT; BLACK JACOB; SMELTZER THOMAS; COLVIN SEAN
权利人:CANOPY HOLDINGS LLC
摘要:A resorcinol with modifications at the 2-position is provided. The reactant resorcinol may have a variety of functional groups at each of the 1, 3, and 5 position such as a hydroxide, a lower alkyl group, a phenyl, a substituted phenyl, a lower alkenyl, or a lower alkynyl sp 2 carbon group (e.g., substituted phenyl, vinyl), sp (e.g., alkyne), hydrogen. The resorcinol is modified at the 2-position with a nucleophile or an electrophile. The resulting resorcinol may serve as a stable intermediate for the synthesis of cannabinoid or cannabinoid derivatives.