CAS: 118754-53-3; 4-Bromo-3,5-Dichlorobenzotrifluoride

相似化合物

402-04-0 384-16-7 344-65-0

上下游产品

sulfuric acid 2,6-dichloro-4-(trifluoromethyl)aniline 2,6-dichloro-4-(trifluoromethyl)benzaldehyde 2,6-dichloro-4-(trifluoromethyl)benzoic acid 5-amino-1-(2,6-dichloro-4-(trifluoromethyl)phenyl)-4-(trifluoromethylthio)-1H-pyrazole-3-carbonitrile

2,6-二氯-4-三氟甲基苯胺置于亚硝酸特丁酯,Copper(Ll) Bromide体系中,用 乙腈 用作溶剂,以85%的收率获得4-溴-3,5-二氯三氟甲苯
参考文献:氟苯腈激发的异恶唑啉和异恶唑的合成
标题:氟苯腈激发的异恶唑啉和异恶唑的合成
摘要:摘要 已知苯基吡唑(或芳基吡唑)作为gaba受体上的gaba门控氯离子通道的非竞争性抑制剂极为有效.该项目涉及合成新型异恶唑和异恶唑啉杂环,它们的结构特征与市售的苯基吡唑氟虫腈相似.合成适当取代的苯乙烯和苯乙炔后,再与几种脂肪族腈氧化物进行1,3-偶极环加成反应,这些化合物是由醛肟与漂白剂原位制备的.确定了这些专门的烯烃和炔烃双亲亲试剂的相对反应速率. 已知苯基吡唑(或芳基吡唑)作为gaba受体上的gaba门控氯离子通道的非竞争性抑制剂极为有效.该项目涉及合成新型异恶唑和异恶唑啉杂环,它们的结构特征与市售的苯基吡唑氟虫腈相似.合成适当取代的苯乙烯和苯乙炔后,再与几种脂肪族腈氧化物进行1,3-偶极环加成反应,这些化合物是由醛肟与漂白剂原位制备的.确定了这些专门的烯烃和炔烃双亲亲试剂的相对反应速率.
Doi:10.1055/s-0034-1378737

专利信息

专利号:US-8410320-B2
优先权日:2010-12-07
标 题 :Method for synthesis of secondary alcohols
发明人：CHENG CHIEN-HONG; KARTHIKEYAN JAGANATHAN; HUANG PANG-CHI
权利人:CHENG CHIEN-HONG; KARTHIKEYAN JAGANATHAN; HUANG PANG-CHI; NAT UNIV TSING HUA
摘要:A method for synthesis of secondary alcohols is provided for pharmaceutical secondary alcohol by addition of organoboronic acids with aldehydes in presence of the cobalt ion and bidentate ligands as the catalyst. In addition, an enantioselective synthesis method for secondary alcohols is also herein provided in the present invention. The present invention has advantages in using less expensive cobalt ion and commercially available chiral ligands as the catalyst, wide scope of organoboronic acids and aldehydes compatible with this catalytic reaction and achieving excellent yields and/or enantiomeric excess.

专利号:US-4898952-A
优先权日:1987-05-29
标 题 :Regioselective synthesis of a 1,5-disubstituted pyrazole
发明人：MURRAY WILLIAM V; WACHTER MICHAEL P
权利人:ORTHO PHARMA CORP
摘要:A highly regioselective synthesis of pyrazoles from a mono-substituted hydrazine and a beta -dicarbonyl compound wherein a carboxylic acid moiety is present on the substituent attached to one of the carbonyls. For example, compounds of the formula (I) are formed in marked preference to isomers of formula (IV): (I) (IV)

专利号:US-7531694-B2
优先权日:2004-07-07
标题:Process for synthesis of 4-4′-diamino-diphenyl-sulfone
发明人：VILLA MARCO; DE FAVERI CARLA; ZANOTTI RICCARDO; CIARDELLA FRANCESCO; BORIN FABRIZIO
权利人:LUNDBECK PHARMACEUTICALS ITALY
摘要:A new process for the preparation and purification of 4-4′-diamino-diphenyl-sulfone (dapsone) is described. The process described is a three step process comprising a condensation reaction with the synthesis of a thioether intermediate and then steps of oxidation and reduction in suitable conditions in order to obtain a product with good yield and purity.

专利号:US-6500955-B1
优先权日:2001-02-02
标 题:One pot synthesis of [2,8-Bis (trifluoromethyl)-4-quinolinyl]-2-pyridinylmethanone, a mefloquine intermediate
发明人：CHAWLA HARMANDER PAL SINGH; JOHAR PERMINDER SINGH; MITTAL ALKA; MEENA RAM AVTAR; NEGI VILLENDRA SINGH
权利人:NAT INST OF PHARMACEUTICAL EDU
摘要:The present invention provides a simple single step process for the preparation of [2,8-bis(trifluoromethyl)-4-quinolinyl]-2-pyridinylmethanone, comprising the step of condensing a halo-quinoline with an alpha-picolyl derivatives in the presence of a solvent, a base and a phase transfer catalyst at −10° C. to +90° C.

专利号:WO-2004031131-A1
优先权日:2002-10-03
标 题 :Improved syntheton synthesis
发明人：KWON TAESOO; GU CHEN; YANG SOON-HA
权利人:SK ENERGY AND CHEMICAL INC; KWON TAESOO; GU CHEN; YANG SOON-HA
摘要:The present disclosure relates to an improved synthesis of the commercially important syntheton ECHB starting from the readily available 3-hydroxy-Ïœ-butyrolactone. The reaction employs a single pot procedure without isolation or purification of the intermediates. It has the advantage over procedures previously employed in the art of using reagents and conditions which minimize undesired side reactions and which can be readily employed at commercial scale. The product is produced in high yield and is readily purified to provide an excellent intermediate for further synthesis of commercially important products such as L-carnitine and the pharmaceutically important active substances used in HMG-coA reductase inhibitor products such as Lipitorè.

专利号:US-4105652-A
优先权日:1977-08-05
标 题 :Synthesis of human β-endorphin
发明人：MEIENHOFER JOHANNES ARNOLD; WANG SU-SUN
权利人:HOFFMANN LA ROCHE
摘要:Human β-endorphin (β h -endorphin) is prepared by solution phase peptide synthesis. Synthesis proceeded via the protected β-endorphin fragments 1-9, 10-18, 19-21 and 22-31.