CAS: 123-38-6; Propanal

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丙烯醛置于氢气,钯体系中,化学反应生成丙醛
参考文献:Pd模型催化剂上丙烯醛的选择性加氢:温度和粒度效应
标题:Pd模型催化剂上丙烯醛的选择性加氢:温度和粒度效应
摘要:Fe 3 O 4上丙烯醛加氢的选择性在220-270 K的温度范围内,研究了纳米级pd负载与纳米尺寸的关系.尽管pd(111)对所需的c = O键加氢生成丙烯醇显示出近100%的选择性,但发现pd纳米粒子对该产品的选择性低得多.使用红外反射吸收光谱法对表面物质的原位检测表明,对丙烯醇的选择性主要取决于氧丙基观众分子的形成.虽然在pd(111)上有效形成了一层氧丙基丙基物种,从而使表面对丙烯醇的形成具有高度选择性,但丙烯醛分解导致co形成,严重阻碍了该过程对pd纳米颗粒的形成.我们表明,可以通过改变粒径和反应温度来调节丙烯醛分解的程度.结果,在250 K下,在12 Nm Pd纳米颗粒上观测到大量的丙烯醇,而较小的(4和7 Nm)纳米颗粒在所研究的任何温度下均未生成丙烯醇.讨论了丙烯形成的粒度依赖性的可能来源.这项工作表明,丙烯醛加氢的选择性受丙烯醛部分加氢到氧丙基表面种类和丙烯醛分解的相对速
Doi:10.1002/chem.201602021

专利信息

专利号:WO-2012017400-A1
优先权日:2010-08-03
标 题 :Synthesis of acyl-pantetheine derivatives and the use thereof in the synthesis of acyl-coenzyme a derivatives
发明人：VAN DIJK ALBERDINA AIKE; BADENHORST CHRISTOFFEL PETRUS STEPHANUS
权利人:UNIV NORTHWEST; VAN DIJK ALBERDINA AIKE; BADENHORST CHRISTOFFEL PETRUS STEPHANUS
摘要:The present invention relates to a novel synthesis method for acyl-pantetheine derivatives. The present invention further relates to the use of said synthesized acyl-pantetheine derivatives as a starting material in the enzymatic synthesis of acyl-coenzyme A derivatives. According to a first aspect thereof, the present invention provides a method for the synthesis of acyl-pantetheine derivatives, the method including the steps of: a) providing a source of pantetheine; b) providing a source of acyl ester; and c) contacting the source of pantetheine with the source of acyl ester to form the corresponding acyl-pantetheine derivative, having the general formula (I), wherein R is an acyl group.The present invention also provides a method for the synthesis of acyl-coenzyme A derivatives as well as the use of a source of pantetheine and a source of acyl ester in the preparation steps of these two methods.

专利号:WO-2009104605-A1
优先权日:2008-02-18
标 题 :Novel intermediate for synthesis of ascofranone having various physiological activities, and novel shortened total synthesis method for ascofranone using the same
发明人：SAIMOTO HIROYUKI; HAGA YASUSHI
权利人:ARIGEN PHARMACEUTICALS INC; SAIMOTO HIROYUKI; HAGA YASUSHI
摘要:In the synthesis of ascofranone, a compound represented by formula (III), (IV), (V) or (VII) or an optical isomer thereof is used as an intermediate for the synthesis. [In the formulae, R 1 and R 2 independently represent a hydrogen atom, a C 1-7 alkyl group, a phenoxyalkyl group having a halogen atom on a carbon atom in a benzene ring therein, or a phenyl group having a C 1-7 alkoxy group or a C 1-7 alkoxycarbonyl group on a carbon atom in a benzene ring therein; and X represents a halogen atom or a group R 5 SO 3 (wherein R 5 represents a C 1-7 alkyl group or a phenyl group having a C 1-7 alkyl group on a carbon atom in a benzene ring therein).] By using the compound, it becomes possible to reduce the number of steps required for the total synthesis of ascofranone to 7 or 8 from 12 which is a number of the steps required for the conventional ascofranone total synthesis processes.

专利号:US-2010099894-A1
优先权日:2006-10-09
标 题 :Method for the Synthesis of Cyclic Acetals by the Reactive Extraction of a Polyol in a Concentrated Solution
发明人：DUBOIS JEAN-LUC; IBORRA CHORNET SARA; VELTY ALEXANDRA I LUCIENNE; CORMA CANOS AVELINO
权利人:DUBOIS JEAN-LUC; IBORRA CHORNET SARA; VELTY ALEXANDRA I LUCIENNE; CORMA CANOS AVELINO
摘要:A method for the synthesis of cyclic acetals comprises reacting at least one carbonyl-function compound selected from aldehydes, ketones, and/or linear acetals, on a polyol in a concentrated aqueous solution exceeding 20 wt % in a reactor containing an acidic catalyst. The carbonyl-function compound is selected so that the cyclic acetal obtained has a water solubility lower than 20000 mg/kg. During the catalytic reaction for the cyclic acetal synthesis, at least one portion of the organic phase containing the cyclic acetal is separated. The acidic catalysis is either homogeneous when using a water-soluble strong acid, or heterogeneous when using a solid acid such as a resin, a zeolite, or any appropriately acidified solid. The extractive reaction method can be used for obtaining high conversions and selectivity.

专利号:WO-2018157416-A1
优先权日:2017-02-28
标题 :Process for synthesis of 3,3,3-trifluropropyl dimethylsilyl propylene ether
发明人：SI LINXU; LI JIAQI; JU CHAOFAN; WU JUNYI
权利人:CHANGSHU 3F ZHONGHAO NEW CHEMICAL MAT CO LTD; NEIMENGGU ALLTOP FLUORINE NEW MAT DEVELOPMENT CO LTD
摘要:Disclosed is a process for the synthesis of 3,3,3-trifluropropyl dimethylsilyl propylene ether, the process comprising the following steps: (1) dimethyl monochlorosilane and propylene alcohol are added into a reactor, and a triethylamine catalyst and an n-hexane reaction solvent are then added, wherein the reaction process requires stirring, and during the process, a constant temperature oil bath is used for heating, and nitrogen is introduced; (2) after the reaction is completed, the product is left to stand for layering, and triethylamine hydrochloride in the lower layer is discharged to obtain crude 3,3,3-trifluropropyl dimethylsilyl propylene ether; and (3) the filtered crude 3,3,3-trifluropropyl dimethylsilyl propylene ether is rectified under a reduced pressure to obtain a high-purity 3,3,3-trifluropropyl dimethylsilyl propylene ether product. The 3,3,3-trifluropropyl dimethylsilyl propylene ether synthesized by the present invention has a lower raw material price, milder reaction conditions, and a safe and reliable reaction process; furthermore, the synthesis process is simple, has fewer side reactions, and produces less waste, wherein same is easy to treat, and the target product is easy to separate and has a high purity.

专利号:US-5145957-A
优先权日:1988-03-18
标 题:Stereoselective synthesis of a chiral cis 3-beta hydrogen (3R) 4-aroyloxy azetidinone
发明人：TSCHAEN DAVID M; LYNCH JOSEPH E; LASWELL WILLIAM L; VOLANTE RALPH P; SHINKAI ICHIRO
权利人:MERCK & CO INC
摘要:A process is described for the stereocontrolled synthesis of (3R,4R)-3-[(1R)-1-hydroxyethyl]-4-benzoyloxyazetidin-2-ones and their derivatives by cycloaddition involving an imine and a ketone, generated from 3(S)-hydroxybutyrate which are useful intermediates in the synthesis of carbapenem antibiotics.

专利号:US-5817751-A
优先权日:1994-06-23
标 题 :Method for synthesis of diketopiperazine and diketomorpholine derivatives
发明人：SZARDENINGS ANNA KATRIN; CAMPBELL DAVID
权利人:AFFYMAX TECH NV
摘要:The present invention relates to the areas of organic and medicinal chemistry. More specifically, the present invention is concerned with combinatorial and solid phase methods for the synthesis of diverse diketopiperazine derivatives, and the use of such methods to create libraries of diverse diketopiperazine derivatives. The present invention has application in the areas of chemical synthesis, the screening for new diketopiperazine derivatives having beneficial medical properties and the use of such screening to provide compositions and methods including diketopiperazine derivatives for treating disease.