CAS: 13139-17-8; N-(Benzyloxycarbonyloxy)Succinimide

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65853-65-8 1802907-98-7 1802907-96-5

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CAS号6066-82-6 N-羟基琥珀酰亚胺 | CAS号501-53-1 氯甲酸苄酯 | CAS号74124-79-1 N,N'-二琥珀酰亚胺基碳酸酯 | CAS号100-51-6 苯甲醇 | CAS号82911-72-6 dicyclohexylami... | CAS号101-83-7 二环己胺 | CAS号5105-78-2 N-苄氧羰基-4-氨基丁酸 | CAS号34637-22-4 3-(苄氧羰基氨基)-1-丙醇 | CAS号53844-02-3 N-苄氧羰基-3-溴乙胺 | CAS号3589-41-1 N-(苄氧羰基)氨基乙腈 | CAS号35677-88-4 N-苄氧羰基-L-高丝氨酸 | CAS号31970-04-4 3-吡咯烷-1-甲酸苄酯 | CAS号4652-65-7 N-苄氧羰基-L-谷氨酸- 5-甲酯 | CAS号39945-54-5 3-溴丙基氨基甲酸苄酯 | CAS号39608-31-6 苄氧羰酰基肌氨酸 | CAS号46460-73-5 N-(3-氨基丙基)氨基甲酸苄酯

N-羟基丁二酰亚胺,氯甲酸苄酯置于三乙胺体系中,用 二氯甲烷 用作溶剂,以75%的收率获得苯甲氧羰酰琥珀酰亚胺
参考文献:扩增显微镜中核酸的通用标记策略
标题:扩增显微镜中核酸的通用标记策略
摘要:扩展显微镜 (Exm) 能够在常规荧光显微镜上对核糖核酸 (Rna) 进行纳米级成像,从而提供有关在(亚)细胞分辨率和空间背景下基因表达的复杂模式的信息.为了扩展此类策略的使用,我们检查了一系列多价试剂,这些试剂允许以统一的方法标记和嫁接脱氧核糖核酸 (Dna) 寡核苷酸探针.我们证明该试剂与第三代原位杂交链式反应rna Fish(原位荧光杂交)技术,同时显示目标转录物的完全保留.此外,我们验证并证明我们的标记方法与多色染色兼容.通过寡核苷酸偶联抗体,我们在 x4 Exm 和 x10 Exm 中表现出优异的性能,在扩展前和扩展后标记策略中,在 x10 Exm 中实现了约 50 Nm 的分辨率.我们的结果表明,我们的多价分子能够使 Exm 的 Dna 寡核苷酸快速功能化.
Doi:10.1021/jacs.1C05931

专利信息

专利号:US-2023286915-A1
优先权日:2020-10-07
标 题 :Synthesis of pyrrole acid derivatives
发明人：WILKINSON ANDREW; COOPER LAN; ORR DAVID; FINLAYSON JONATHAN; BUNT ADAM; KIRKHAM JAMES; LYTH DAVID; BLADES KEVIN
权利人:INFEX THERAPEUTICS LTD
摘要:This invention relates to the synthesis of compounds that can be used to treat bacterial infections in combination with other antibacterial agents, and more specifically in combination with a class of antibacterial agents known as carbapenems. The compounds resulting from the novel methods of the present invention are enzyme inhibitors and more particularly are metallo-β-lactamase inhibitors.

专利号:US-7728135-B2
优先权日:2005-01-06
标 题:Synthesis of CCR5 receptor antagonists
发明人：SHI XIONGWEI; ZHU MAN; LEONG WILLIAM; DAHANUKAR VILAS; ZAVIALOV ILIA A; PROIETTI CECELIA; ZHAO SHANNON; LEE HONG-CHANG; LIU YI; NGUYEN HOA N; WU WENXUE; D SA BOSCO; LIANG FENG; TRAN LOC THANH
权利人:SCHERING CORP
摘要:The present invention is directed to the synthesis of 4-[4-[(R)-[1-[cyclopropylsulfonyl)-4-piperidinyl](3-fluorophenyl)methyl]-3(S)-methyl-1-piperazinyl]-1-[(4,6-dimethyl-5-pyrimidinyl)carbonyl]-4-methylpiperidine], and intermediates therefor from readily available starting materials by a novel route.

专利号:US-11028123-B2
优先权日:2018-04-10
标题 :Capping of unprotected amino groups during peptide synthesis
发明人：HENKEL BERND; METZENTHIN TOBIAS; GERKEN MANFRED; FIEDLER WOLFGANG
权利人:SANOFI AVENTIS DEUTSCHLAND
摘要:The present invention relates to a method for the synthesis of a polypeptide comprising a pre-determined amino acid sequence. The method according to the invention comprises coupling cycles of coupling an N-terminally protected amino acid building block C-terminally at an unprotected N-terminal amino group of an amino acid chain, wherein at least one coupling cycle comprises a coupling step (a), a capping step (b), and a de-protecting step (c).

专利号:US-8487108-B2
优先权日:2005-11-14
标题 :Piperidinyl carbamate intermediates for the synthesis of aspartic protease inhibitors
发明人：BALDWIN JOHN J; CLAREMON DAVID A; TICE COLIN; CACATIAN SALVACION; DILLARD LAWRENCE W; ISHCHENKO ALEXEY V; YUAN JING; XU ZHENRONG; MCGEEHAN GERARD; SIMPSON ROBERT D; SINGH SURESH B; ZHAO WEI; FLAHERTY PATRICK T
权利人:BALDWIN JOHN J; CLAREMON DAVID A; TICE COLIN; CACATIAN SALVACION; DILLARD LAWRENCE W; ISHCHENKO ALEXEY V; YUAN JING; XU ZHENRONG; MCGEEHAN GERARD; SIMPSON ROBERT D; SINGH SURESH B; ZHAO WEI; FLAHERTY PATRICK T; VITAE PHARMACEUTICALS INC
摘要:The present invention is directed to aspartic protease inhibitors. Certain aspartic protease inhibitors of the invention can be represented by the following structural formula or a pharmaceutically acceptable salt thereof. The present invention is also directed to pharmaceutical compositions comprising the disclosed aspartic protease inhibitors. The present invention is further directed to methods of antagonizing one or more aspartic proteases in a subject in need thereof, and methods for treating an aspartic protease mediated disorder in a subject using the disclosed aspartic protease inhibitors.

专利号:WO-2013136265-A1
优先权日:2012-03-13
标 题:Synthesis of an intermediate of an antiviral compound
发明人：ATTOLINO EMANUELE; BOVE ALESSIO; BRUNOLDI ENRICO; ALLEGRINI PIETRO
权利人:DIPHARMA FRANCIS SRL
摘要:Process for the preparation of a cyclopropylamide compound which is useful as a structural unit in a process for the preparation of a viral protease inhibitor.

专利号:US-6307071-B1
优先权日:1998-03-02
标 题:Synthesis of paclitaxel from baccatin III by protection of the 7-hydroxyl of baccatin III using a strong base and an electrophile
发明人：GIBSON FRANCIS S
权利人:BRISTOL MYERS SQUIBB CO
摘要:Process for synthesizing paclitaxel by treating baccatin III with a strong base in a solvent, adding an electrophile to the solution to form a 7-O-protected baccatin III derivative, reacting the 7-O-protected baccatin III derivative with a protected paclitaxel sidechain in a solvent such that the protected paclitaxel sidechain is coupled to the 13-hydroxyl of the 7-O-protected baccatin III, and subsequently deprotecting the protected paclitaxel sidechain and the 7-O protecting group to form paclitaxel, and intermediates used therein.