CAS: 13754-38-6; 1-Benzoylpiperazine

相似化合物

56227-55-5 111752-26-2 100939-91-1

上下游产品

piperazine benzoyl chloride O-benzoyl-NN-dimethyl-N'-(N-methyl-2,4-dinitroanilino)isourea p-nitrophenylbenzoate 1-(4-amino-6-morpholin-4-yl-[1,3,5]triazin-2-ylmethyl)-4-benzoyl-piperazine d]pyrimidin-4-yl)-piperazine1-benzoyl-4-(2-methyl-benzo[4,5]thieno[3,2-d]pyrimidin-4-yl)-piperazine 4-Benzoyl-piperazine-1-carboxylic acid (2-dimethylamino-ethyl)-amide 2-chloro-3-(4'-benzoylpiperazino)-1,4-naphthoquinone

(4-Tert-Butylpiperazin-1-yl)Phenylmethanone置于三氟乙酸,盐酸体系中,用 二氯甲烷,水 用作溶剂,化学反应 0.5H,以0.583 G的收率获得1-苯甲酰哌嗪
参考文献:取代邻羟基苯酮化合物在制备治疗神经变性 疾病药物中的应用
标题:取代邻羟基苯酮化合物在制备治疗神经变性 疾病药物中的应用
摘要:本发明公开了一种取代邻羟基苯酮化合物或其在药学上可接受的盐在制备治疗神经变性疾病药物中的应用,其结构如式i所示,式i中,R1的结构式为r2的结构式独立地为‑nr8R9或者含有‑n的五元环,六元环或七元环;R3独立地选自h,羟基,胺基,C1‑c10烷基,C1‑c10烯基,芳基,或c1‑c10卤代烷基,C1‑c4氧杂烷基,C1‑c4氮杂烷基,或卤素;该类化合物不仅具有乙酰胆碱酯酶抑制活性,其水解产物还具有金属离子螯合作用,因而可以从多个靶点进行治疗,适合用于制备治疗神经变性疾病药物,特别适合用于治疗阿尔茨海默症或帕金森氏病,具有较好的神经变性疾病应用前景.

专利信息

专利号:WO-2010108584-A1
优先权日:2009-03-26
标题:Synthesis of n-substituted furan-2(5h)-ones
发明人：IGNATYEV NIKOLAI MYKOLA; ZLOTIN SERGEI G; SIMIRSKAYA NINA I
权利人:MERCK PATENT GMBH; IGNATYEV NIKOLAI MYKOLA; ZLOTIN SERGEI G; SIMIRSKAYA NINA I
摘要:The present invention relates to a process for preparing N-substituted furan-2(5H)-ones where the reaction medium comprises at least one Ionic Liquid, to the use of Ionic Liquids for preparing furan-2(5H)-ones, and to compounds preparable by the aforementioned process.

专利号:US-9994558-B2
优先权日:2013-09-20
标题 :Multicyclic compounds and methods of using same
发明人：BALOGLU ERKAN; SHACHAM SHARON; SENAPEDIS WILLIAM; MCCAULEY DILARA; LANDESMAN YOSEF; GOLAN GALI; KALID ORI; SHECHTER SHARON
权利人:KARYOPHARM THERAPEUTICS INC
摘要:The invention generally relates to compounds represented by Structural Formula I: or a pharmaceutically acceptable salt thereof, wherein the variables are as defined and described herein. The invention also includes the synthesis and use of a compound of structural formula I, or a pharmaceutically acceptable salt or composition thereof, e.g., in treatment of cancer (e.g., mantle cell lymphoma), and other diseases and disorders (e.g., PAK-mediated, for example, PAK4-mediated, diseases and disorders).

专利号:US-9938258-B2
优先权日:2012-11-29
标 题:Substituted 2,3-dihydrobenzofuranyl compounds and uses thereof
发明人：BALOGLU ERKAN; SHECHTER SHARON; SHACHAM SHARON; MCCAULEY DILARA; SENAPEDIS WILLIAM; GOLAN GALI; KALID ORI
权利人:KARYOPHARM THERAPEUTICS INC
摘要:The invention generally relates to substituted 2,3-dihydrobenzofuranyl compounds, and more particularly to a compound represented by Structural Formula I: n nor a pharmaceutically acceptable salt thereof, wherein the variables are as defined and described herein. The invention also includes the synthesis and use of a compound of Structural Formula I, or a pharmaceutically acceptable salt or composition thereof, e.g., in the treatment of cancer (e.g., mantle cell lymphoma), and other diseases and disorders.

专利号:US-9663482-B2
优先权日:2012-08-03
标 题:Substituted piperazinyl acetohydrazide procaspase-activating compounds
发明人：HERGENROTHER PAUL J; ROTH HOWARD S
权利人:UNIV ILLINOIS
摘要:The invention provides compounds and compositions useful for the modulation of certain enzymes. The compounds are of Formula I n nThe compounds and compositions can induce of cell death, particularly cancer cell death. The invention also provides methods for the synthesis and use of the compounds and compositions, including the use of compounds and compositions in therapy for the treatment of cancer and selective induction of apoptosis in cells.

专利号:CN-1016171-B
优先权日:1988-07-04
标题:Synthesis method of high-purity P, P' -diaminobenzoyl piperazine