CAS: 15028-39-4; (S)-Methyl 2-Amino-2-Phenylacetate Hydrochloride

相似化合物

19883-41-1 15028-40-7 37760-98-8

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CAS号67-56-1 甲醇 | CAS号2935-35-5 (|S|)-(+)-α-苯甘氨酸 | CAS号235786-93-3 (S)-methyl 2-((... | CAS号77-76-9 2,2-二甲氧基丙烷 | CAS号15028-40-7 甲基-2-氨基-2-苯乙酸酯盐酸盐 | CAS号63430-99-9 methyl N-4'-met... | CAS号875-74-1 D-(-)-α-苯基甘氨酸 | CAS号100-52-7 苯甲醛 | CAS号1052209-96-7 (S)-5-苯基吗啉-3-酮 | CAS号2935-35-5 (|S|)-(+)-α-苯甘氨酸 | CAS号19379-33-0 L-(+)-Ampicillin | CAS号67341-01-9 N-(叔丁氧羰基)-DL-2-苯甘氨醇 | CAS号20989-17-7 L-苯甘氨醇 | CAS号36060-84-1 乙酰基-L-苯基甘氨酸甲酯 | CAS号14328-63-3 L-环己基甘氨酸甲酯盐酸盐 | CAS号129704-13-8 (S)-(-)-2-氨基-1,... | CAS号219886-80-3 methyl (2R)-2-[...

[(S)-1-(4-Methoxy-Phenyl)-Ethyl]-[1-Phenyl-Meth-(E)-Ylidene]-Amine置于盐酸,Ammonium Cerium(Iv) Nitrate,Lithium Perchlorate体系中,用 水,乙腈 用作溶剂,化学反应 4.0H,反应生成(S)-(+)-2-苯甘氨酸甲酯 盐酸盐
参考文献:醛亚胺中的三甲基甲硅烷基氰化物及其在合成(S)-苯基甘氨酸甲酯中的应用
标题:醛亚胺中的三甲基甲硅烷基氰化物及其在合成(S)-苯基甘氨酸甲酯中的应用
摘要:研发了在乙腈中存在liclo 4或bf 3 .et 2 O的情况下,向各种芳基醛亚胺中添加tmscn(斯特雷克反应).该反应以非常高的收率提供了加成产物.该方法已成功地用于合成(S)-苯基甘氨酸甲酯.
Doi:10.1016/j.Tetlet.2004.11.015

专利信息

专利号:EP-2173892-B8
优先权日:2007-07-27
标题:Process for the preparation of immobilised recombinant Penicillin Acylase biocatalyst from Achromobacter sp CCM 4824 expressed in E. coli BL21 CCM 7394 and its use for the synthesis of beta-lactam antiobiotics
发明人：DATLA ANUPAMA; RAJASEKAR VYASARAYANI WILLIAMS; KYSLIK PAVEL; BECKA STANISLAV; KRISHNAKANT ASHAR TRUPTI; YOGESH ZAMBRE SUJATA; NIKUNJ KUMAR
权利人:FERMENTA BIOTECH LTD
摘要:The present invention discloses isolation of Penicillin Acylase (PA) from Achromobacter sp CCM 4824 expressed in recombinant strain E. coli BL21 CCM 7394 bearing the recombinant plasmid pKXIP1 and processing of PA into biocatalyst useful for the industrial synthesis of antibiotics. More particularly the invention discloses a synthesis of semi-synthetic β-lactam antibiotics in the reaction mixture consisting of activated acyl-donor (D-p-hydroxyphenylglycine methyl ester or amide for Amoxicillin and Cefadroxil; D-phenylglycine methyl ester or amide for Ampicillin and Cephalexin) and nucleophile (6-APA or 7-ADCA) catalyzed by PA obtained from recombinant E. coli BL21 CCM 7394 as the biocatalyst.

专利号:US-2018312463-A1
优先权日:2015-10-22
标题:Synthesis of Cyclohexane Carboxamide Derivatives Useful as Sensates in Consumer Products
发明人：YELM KENNETH EDWARD; WOS JOHN AUGUST; BUNKE GREGORY MARK; FREDERICK HEATH; HAUGHT JOHN CHRISTIAN; HOKE STEVEN HAMILTON; SREEKRISHNA KOTI TATACHAR; LIN YAKANG
权利人:PROCTER & GAMBLE
摘要:Synthesis methods to produce a series of carboxamides built off of an (S)-2-amino acid backbone or an (R)-2-amino acid backbone, depending upon the desired diastereomer of the end product.

专利号:US-6218138-B1
优先权日:1998-05-26
标 题 :Synthesis of beta-lactam antibiotics with immobilized penicillin amidase
发明人：ILHAN FERHAT; KRAEMER DIETER
权利人:UNIFAR KIMYA SANAYI VE TICARET
摘要:Beta-lactam antibiotics are synthesized by reacting an amino-beta-lactam component with a corresponding amino-group-containing acylating side-chain component in the presence of penicillin amidase from E. coli covalently immobilized on support particles. The resulting beta-lactam antibiotic product is solubilized by adding an acid such as sulfuric acid to lower the pH to 1.0 at a temperature in the range of 0° C. to +5° C. The immobilized penicillin amidase is substantially inactivated by the acid. After separating the beta-lactam antibiotic product, the immobilized penicillin amidase is substantially reactivated for reuse in antibiotic synthesis by treatment with a buffer having about a neutral pH. Antibiotics that can be produced include ampicillin, amoxicillin, cephalexin, cefaclor and cefadroxil. Support particles that can be used include particles having a macroporous structure and a particle diameter of 10-1000 mum, particles having oxirane groups, particles made of a synthetic polymer and inorganic particles such as porous glass particles.

专利号:US-6515126-B2
优先权日:2000-02-28
标 题:Chemical synthesis of spirocyclic piperidines by double ring-closing metathesis
发明人：ASHWOOD MICHAEL STEWART; COTTRELL IAN FRANK; COWDEN CAMERON JOHN; WALLACE DEBRA JANE
权利人:MERCK SHARP & DOHME
摘要:The present invention relates to a process for the preparation of a compound of formula (I) n wherein Ts is a tosylate group and R is an alkyl group, an unsubstituted phenyl or substituted phenyl ring, or a benzyl or substituted benzyl group; which comprises: n (i) cyclising a compound of formula (II) n in the presence of a suitable catalyst; and n (ii) purifying and collecting the resultant compound of formula (I).

专利号:EP-0946499-B1
优先权日:1996-11-22
标 题 :N-(aryl/heteroaryl/alkylacetyl) amino acid amides, pharmaceutical compositions comprising same, and methods for inhibiting beta-amyloid peptide release and/or its synthesis by use of such compounds
发明人：WU JING; TUNG JAY S; NISSEN JEFFREY S; MABRY THOMAS E; LATIMER LEE H; EID CLARK NORMAN; AUDIA JAMES E
权利人:ELAN PHARM INC; LILLY CO ELI
摘要:Disclosed are compounds which inhibit beta -amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits beta -amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions. Said compounds are represented by formula (I), wherein R<1> is selected from the group consisting of: a) alkyl, alkenyl, alkaryl, alkcycloalkyl, aryl, cycloalkyl, cycloalkenyl, heteroaryl and heterocyclic; b) a substituted phenyl group of formula (II), wherein R is alkylene of from 1 to 8 carbon atoms, m is an integer equal to 0 or 1, and c) 1- or 2-naphthyl substituted at the 5, 6, 7 and/or 8 positions, R<2> is selected from the group consisting of hydrogen, alkyl of from 1 to 4 carbon atoms, alkylalkoxy of from 1 to 4 carbon atoms, alkylthioalkoxy of from 1 to 4 carbon atoms; and R<3> and R<3'> are independently selected from the group consisting of: (a) hydrogen, (b) alkyl, (c) -(R<7>)n(W)p, wherein R<7> is an alkylene group, W is selected from the group consisting of (i) formula (A); (ii) heteroaryl; and (iii) N-heterocyclic, and n is an integer equal to 0 or 1, and p is an integer equal to 1 to 3; (d) -CH( phi )CH2C(O)O-Q where Q is selected from the group consisting of alkyl, aryl, heteroaryl and heterocyclic; X' is hydrogen, hydroxy or fluoro; X'' is hydrogen, hydroxy or fluoro, or X' and X'' together form an oxo group, Z is selected from the group consisting of a bond covalently linking R<1> to -CX'X''-, oxygen and sulfur.

专利号:US-6849650-B2
优先权日:1998-02-27
标 题:Heterocyclic compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
发明人：THORSETT EUGENE D; PORTER WARREN J; NISSEN JEFFREY S; LATIMER LEE H; AUDIA JAMES E; DROSTE JAMES
权利人:ATHENA NEUROSCIENCES INC; LILLY CO ELI
摘要:Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.