CAS: 1570-45-2; Ethyl Isonicotinate

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CAS号55-22-1 异烟酸 | CAS号64-17-5 乙醇 | CAS号872-85-5 4-吡啶甲醛 | CAS号14906-37-7 异烟酸乙酯1-氧化物 | CAS号54-85-3 异烟肼 | CAS号74-96-4 溴乙烷 | CAS号25108-37-6 Isonicotinicaci... | CAS号100-48-1 4-氰基吡啶 | CAS号14254-57-0 异烟酸酰氯 | CAS号490-11-9 吡啶-3,4-二羧酸 | CAS号36209-51-5 4-氨基-5-吡啶-4H-三唑硫醇 | CAS号54-85-3 异烟肼 | CAS号3731-38-2 3-奎宁环酮 | CAS号40175-06-2 1-甲基-1,2,3,6-四氢... | CAS号38557-82-3 Isonicotinamide... | CAS号40034-44-4 3-吡啶-4-基苯胺 | CAS号586-95-8 4-吡啶甲醇 | CAS号149-17-7 异烟腙 | CAS号91912-53-7 3-(吡啶-4-基)-1H-吡唑-5-胺 | CAS号93913-86-1 1-吡啶-4-哌啶-4-甲酸

异烟酸酰氯置于三乙胺体系中,用 乙醚,乙醇 用作溶剂,化学反应生成异烟酸乙酯
参考文献:金属离子催化及抑制烟酸4-硝基苯酯和异烟酸与碱金属乙醇在无水乙醇中的亲核取代反应
标题:金属离子催化及抑制烟酸4-硝基苯酯和异烟酸与碱金属乙醇在无水乙醇中的亲核取代反应
摘要:一项关于 4-硝基苯基烟酸酯 5 和异烟酸酯 6 与碱金属乙醇盐 Etom(m = K,Na 和 Li)在无水乙醇中的亲核取代反应的动力学研究报道.对于 5 和 6 与 Etok 和 Etona 的反应,伪一级速率常数与 Etom 浓度的关系曲线显示出向上曲率,但对于 Etoli 的反应几乎是线性的.分解成 和 (即分别与解离和离子对 Etom 反应的二级速率常数)表明 > 但是 .已经得出结论,离子通过增加羰基碳原子的亲电性,通过形成 4 元环状过渡态或 来催化反应.然而,已发现离子催化对 5 和 6 的反应的重要性远低于对 4-硝基苯基吡啶甲酸酯 4 的相应反应,据报道其通过 5 元循环过渡态进行.尽管 5 和 6 的反应性明显高于 4-硝基苯甲酸 3,但 5 和 6 的反应比 3 的反应小. 5 和 6 的酰基部分中的氮原子的吸电子能力已被提出负责反应性的增加和比率的降低.
Doi:10.5012/bkcs.2011.32.6.1951

专利信息

专利号:US-8735586-B2
优先权日:2007-06-26
标 题 :Regioselective copper catalyzed synthesis of benzimidazoles and azabenzimidazoles
发明人：ALONSO JORGE; LINDENSCHMIDT ANDREAS; NAZARÉ MARC; URMANN MATTHIAS; HALLAND NIS; RKYEK OMAR
权利人:ALONSO JORGE; LINDENSCHMIDT ANDREAS; NAZARÉ MARC; URMANN MATTHIAS; HALLAND NIS; RKYEK OMAR; SANOFI SA
摘要:The present invention relates to a process for the regioselective synthesis of compounds of the formula I, n nwherein R0; R1; R2; R3; R4; R5; A1; A2; A3; A4, Q and J have the meanings indicated in the claims. The present invention provides a direct copper catalyzed regioselective process to a wide variety of unsymmetrical, multifunctional N-substituted benzimidazoles or azabenzimidazoles of formula I starting from 2-halo-nitroarenes and N-substituted amides.

专利号:US-9266902-B2
优先权日:2008-07-29
标题:Labelling reagents having a pyridine nucleus bearing a diazomethyl function, process for synthesis of such reagents and processes for detection of biological molecules
发明人：LAURENT ALAIN; LAAYOUN ALI; KOTERA MITSUHARA
权利人:LAURENT ALAIN; LAAYOUN ALI; KOTERA MITSUHARA; BIOMERIEUX SA; UNIV STRASBOURG; CENTRE NAT RECH SCIENT
摘要:A process for synthesis of a labelling reagent, a process for the labelling of a biological molecule, a labelled biological molecule obtained by the process, a process for labelling and fragmentation of a single or double strand nucleic acid, a labelled nucleic acid capable of being obtained by the process, a kit for detection of a target nucleic acid containing a labelled nucleic acid, a solid support onto which is attached a reagent and a process for capture of nucleic acids.

专利号:EP-2173747-B1
优先权日:2007-06-26
标 题:A regioselective metal catalyzed synthesis of annelated benzimidazoles and azabenzimidazoles
发明人：ALONSO JORGE; LINDENSCHMIDT ANDREAS; NAZARE MARC; R KYEN OMAR; URMANN MATHIAS; HALLAND NIS
权利人:SANOFI SA
摘要:The present invention relates to a process for the regioselective synthesis of compounds of the formula I, wherein R1; R2; R3; R4; J1; J2; J3; J4 and G have the meanings indicated in the claims. The present invention provides a direct metal, e.g. palladium or copper, catalyzed, regioselective process to a wide variety of unsymmetrical, multifunctional N-substituted benzimidazoles or azabenzimidazoles of formula I starting from 2-halo-nitroarenes and N-substituted amides.

专利号:WO-2024061972-A1
优先权日:2022-09-20
标 题:Methods and platform for chemical synthesis
发明人：CRONIN LEE; MANZANO SEBASTIÃ?N; ZALESSKIY SERGEY; KITSON PHILIP; WANG HSIN
权利人:UNIV GLASGOW COURT
摘要:The invention relates to a method and apparatus for performing and characterising a chemical synthesis, such as those performed with an automated chemical synthesis platform, including such that are portable platforms, the method comprising the steps of: performing a chemical synthesis in a chemical synthesiser; recording analytical data during the chemical synthesis, and developing a profile for the analytical data recorded over time; and comparing the profile for the chemical synthesis against a reference profile, which reference profile is the analytical data recorded over time for a reference chemical synthesis, wherein the chemical synthesis and the reference chemical synthesis share at least the same reagents and method steps for the same intended product, such as the chemical synthesis and the reference chemical synthesis sharing the same instruction set. The method and apparatus are for intended for use in replication of approved, chemical syntheses based on common reaction platforms.

专利号:US-2010261909-A1
优先权日:2007-06-26
标题 :Regioselective copper catalyzed synthesis of benzimidazoles and azabenzimidazoles

专利号:WO-02072582-A1
优先权日:2001-03-12
标 题 :Methods for the synthesis of densely functionalized pyrrolidine template libraries