1-Tert-Butyl 3,5-Dimethyl Piperidine-1,3,5-Tricarboxylate 以60的收率获得benzimidavir苯并咪唑核苷 参考文献:Antiviral Benzimidazole Nucleoside Analogues And A Method For Their 标题:Antiviral Benzimidazole Nucleoside Analogues And A Method For Their 摘要:本发明涉及苯并咪唑衍生物及其在医疗疗法中的使用,特别是用于治疗或预防由疱疹病毒引起的病毒感染.该发明还涉及苯并咪唑衍生物的制备以及含有它们的制药配方.
专利号:US-8614312-B2 优先权日:2008-02-21 标 题 :Method for preparing nucleotides and related analogues by synthesis on soluble substrate, and biological tools thus prepared 发明人:PEYROTTES SUZANNE; PERIGAUD CHRISTIAN; CRAUSTE CELINE 权利人:PEYROTTES SUZANNE; PERIGAUD CHRISTIAN; CRAUSTE CELINE; CENTRE NAT RECH SCIENT; UNIV MONTPELLIER II 摘要:The invention concerns a method for preparing monomer nucleotides or nucleotide analogues comprising the steps of: (1) coupling a soluble polyethylene glycol support provided with at least one diacid or ether-acid linker and a monomer nucleoside or nucleoside analogue to an amine group or hydroxyl group of the nucleoside with the aid of a coupling agent; (2) at least one step for phosphorylation of said nucleoside or nucleoside analogue coupled to said support with a phosphorylation agent; (3) cleavage of said support and recovery of at least one monomer nucleotide or nucleotide analogue. The nucleotides prepared are biological tools.
专利号:US-12377078-B2 优先权日:2022-10-12 标题 :Viral inhibitors, the synthesis thereof, and intermediates thereto 发明人:DEPUE JEFFREY SCOTT; TIPPARAJU SURESH KUMAR; REISCH HELGE ALFRED; TANG DATONG; RAMACHANDRAN KISHORE 权利人:TAKEDA PHARMACEUTICALS CO 摘要:The present disclosure discloses compositions comprising maribavir, methods of providing the same, and compositions providing intermediates useful in providing maribavir. Maribavir (((2S,3S,4R,5S)-2-(5,6-dichloro-2-(isopropylamino)-1H-benzo[d]imidazol-1-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol) is a benzimidazole riboside and is an orally available antiviral medication against cytomegalovirus (CMV).
专利号:KR-20010043457-A 优先权日:1998-05-08 标题 :Nucleic acid molecules which code for enzymes derived from wheat and which are involved in the synthesis of starch
专利号:AR-014973-A1 优先权日:1998-04-07 标 题 :FORM VI OF 5,6-DICLORO-2- (ISOPROPILAMINE) -1-BETA-L-RIBOFURANOSIL-1H-BENCIMIDAZOL, USE OF THE SAME IN THE PREPARATION OF MEDICINES, FORMULATIONS THAT LACONTIEN AND PROCESSES FOR SYNTHESIS
专利号:RU-2145963-C1 优先权日:1994-07-07 标题 :Derivatives of 5,6-dichlorobenzimidazole, method of their synthesis, pharmaceutical composition and method of treatment and prophylaxis of viral infections