CAS: 25462-85-5; 2-Chloro-6-Methylisonicotinic Acid

相似化合物

3998-88-7 3998-90-1 25462-98-0

上下游产品

CAS号86454-13-9 2-羟基-6-甲基异烟酸 | CAS号3998-90-1 2-氯-6-甲基-异烟酸甲酯 | CAS号98491-78-2 1,2-二氢-6-甲基-2-氧... | CAS号30838-93-8 2-氯-4,6-二甲基吡啶 | CAS号18619-97-1 3-氰基-2-羟基-6-甲基异烟酸乙酯 | CAS号3998-88-7 2-氯-6-甲基吡啶-4-羧酸乙酯 | CAS号3998-90-1 2-氯-6-甲基-异烟酸甲酯 | CAS号19353-99-2 2-氯-6-甲基-异烟酸肼 | CAS号226917-15-3 2-二甲基氨基-6-甲基异烟酸 | CAS号1011264-05-3 2-乙氧基-6-甲基异烟酸 | CAS号1029128-50-4 2-氨基-6-甲基异烟酸甲酯 | CAS号152815-18-4 (2-氯-6-甲基吡啶-4-基)甲醇 | CAS号4021-11-8 2-甲基-4-羧基吡啶 | CAS号109-06-8 2-甲基吡啶 | CAS号26413-58-1 2-氯-6-甲基吡啶-4-羰酰氯

1,2-二氢-6-甲基-2-氧代-4-啶啶-4-羧酸乙酯置于氢氧化钾,五氯化磷,三氯氧磷体系中,化学反应生成2-氯-6-甲基吡啶-4-羧酸
参考文献:Parasympathetic Blocking Agents. Iii. N-Alkylpiperidinecarboxylic Esters1
标题:Parasympathetic Blocking Agents. Iii. N-Alkylpiperidinecarboxylic Esters1
摘要:
Doi:10.1021/ja01512A050

专利信息

专利号:US-2010004245-A1
优先权日:2006-10-20
标 题:Azacycloalkane derivatives as inhibitors of stearoyl-coenzyme a delta-9 desaturase
发明人：OBALLA RENATA M; DESCHENES DENIS; GAGNON MARC; LEBLANC YVES; POWELL DAVID; RAMTOHUL YEEMAN K
权利人:MERCK FROSST CANADA LTD
摘要:Azacycloalkane derivatives of structural formula (I) are selective inhibitors of stearoyl-coenzyme A delta-9 desaturase (SCD1) relative to other known stearoyl-coenzyme A desaturases. The compounds of the present invention are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease, such as atherosclerosis; obesity; diabetes; neurological disease; metabolic syndrome; insulin resistance; and liver steatosis.

专利号:US-9663511-B2
优先权日:2012-03-26
标题:Sphingosine 1-phosphate receptor antagonists
发明人：SWENSON ROLF E
权利人:ARROYO BIOSCIENCES LLC
摘要:The present invention relates to sphingosine-1-phosphate (S1P) receptors and compounds of the general formula: n nthat are useful in the treatment and prevention of conditions associated with such receptors. More specifically, the present invention relates to the synthesis and use of sphingosine 1-phosphate receptor 2 (S1P 2 ) antagonists that are useful in the treatment of cancer, atherosclerosis, diabetic retinopathy, and other inflammatory diseases. Among these inflammatory diseases that could be treated with these S1P 2 antagonist are those characterized by fibrosis including chronic lung disease, chronic kidney and liver disease, chronic heart disease, and skin diseases such as sclerosis/scleroderma. The S1P 2 antagonists can also be used in the treatment of glioblastoma multiforme (brain cancer), pediatric neuroblastoma, and other cancers.

专利号:RU-2194701-C2
优先权日:1995-12-18
标 题 :Derivatives of quinazoline, methods of their synthesis, pharmaceutical composition comprising thereof and method of achievement of anti-angiogenic effect and/or effect of decrease of vascular penetration with their using