CAS: 38235-71-1; 3-Hydrazinylbenzoic Acid

上下游产品

CAS号99-05-8 间氨基苯甲酸 | CAS号7647-01-0 盐酸 | CAS号25116-40-9 m-carboxybenzen... | CAS号855196-97-3 3-isopropyliden... | CAS号7732-18-5 水 | CAS号90556-87-9 3-肼基苯甲酸乙酯 | CAS号1843-35-2 3-叠氮苯甲酸 | CAS号99-05-8 间氨基苯甲酸 | CAS号622-37-7 叠氮苯 | CAS号103027-96-9 吲哚-2,4-二甲酸 | CAS号729613-71-2 2, 3, 4, 9-四氢-1... | CAS号784143-99-3 6,7,8,9-tetrahy... | CAS号60297-63-4 3-(4,5-二氢-3-甲基-...

间氨基苯甲酸置于盐酸,Sodium Nitrite,Clh*cl2Sn体系中,用 水 作为反应溶剂,化学反应 0.67H,反应生成 3-肼基苯甲酸
参考文献:通过活性导向组合化学合成策略发现新型人磷酸甘油酸脱氢酶抑制剂
标题:通过活性导向组合化学合成策略发现新型人磷酸甘油酸脱氢酶抑制剂
摘要:丝氨酸是从头合成嘌呤和脱氧胸苷所必需的一碳单元的来源,在癌细胞的生长中起着至关重要的作用.磷酸甘油酸脱氢酶 (Phgdh) 催化丝氨酸从头生物合成中的第一个限速步骤,已成为治疗癌症的有希望的靶点.在这里,我们从基于酶促测定的内部小分子库的筛选中确定了h-G6作为潜在的 Phgdh 抑制剂.我们采用了活性导向的组合化学合成策略来优化这种命中化合物.发现化合物b36是非竞争性和最有前途的化合物,其对 Phgdh 的ic 50值为 5.96 +/-0.61 μm.化合物b36抑制人乳腺癌和卵巢癌细胞的增殖,减少细胞内丝氨酸合成,破坏dna合成,并诱导细胞周期停滞.总的来说,我们的结果表明b36是一种新型的 Phgdh 抑制剂,它可能是一种有前景的调节丝氨酸合成途径的调节剂,并且可能是一种潜在的抗癌先导物,值得进一步探索.
DOI:10.1016/j.Bioorg.2021.105159

专利信息

专利号:US-11040938-B2
优先权日:2016-07-27
标 题 :Continuous flow process for the synthesis of phenylhydrazine salts and substituted phenylhydrazine salts
发明人：MA BING; PAN SHUAI
权利人:SHANGHAI HYBRID—CHEM TECH; SHANGHAI HYBRID CHEM TECH
摘要:The present invention provided a continuous flow process for the synthesis of phenylhydrazine salts and substituted phenylhydrazine salts. Diazotization, reduction, acidic hydrolysis and salifying with acids are innovatively integrated together. Using acidic liquids of aniline or substituted aniline, diazotization reagents, reductants and acids as raw materials, phenylhydrazine derivative salts is obtained through the synthesis process, which is a three-step continuous tandem reaction including diazotization, reduction, acidic hydrolysis and salifying. The described synthesis process is a kind of integrated solutions, which is carried out in an integrated reactor. The feed inlets of the integrated reactor are continuously filled with raw materials. In the integrated reactor, diazotization, reduction, acidic hydrolysis and salifying are carried out continuously and orderly, and phenylhydrazine salts or substituted phenylhydrazine salts is obtained in the outlet of the integrated reactor without interruption. The total reaction time is no more than 20 min.

专利号:US-2011263540-A1
优先权日:2008-07-25
标题 :Small-molecule inhibitors of protein synthesis inactivating toxins
发明人：PANG YUAN-PING; TUMER NILGUN EREKEN; MILLARD CHARLES B
权利人:PANG YUAN-PING; TUMER NILGUN EREKEN; MILLARD CHARLES B
摘要:Small-molecule inhibitors of a protein synthesis inhibiting toxin, e.g., ricin, abrin, Shiga, and Shiga-like toxins, as well as methods of using the inhibitors are provided. Further provided are methods of identifying small-molecule inhibitors of a protein synthesis inhibiting toxin.

专利号:US-2019152896-A1
优先权日:2016-07-27
标题 :Continuous Flow Process For the Synthesis of Phenylhydrazine Salts and Substituted Phenylhydrazine Salts

专利号:US-8030311-B2
优先权日:2005-04-14
标题:Phenylacetamides suitable as protein kinase inhibitors
发明人：BOLD GUIDO; FURET PASCAL; GUAGNANO VITO; MCCARTHY CLIVE; VAUPEL ANDREA
权利人:NOVARTIS AG
摘要:The invention relates to compounds of the formula (I) wherein the moieties R1, R2, R3, R9, R10 and Q and X, Y and Z are as defined in the specification, and salts thereof, as well as their use, methods of use for them and method of their synthesis, and the like. The compounds are protein kinase inhibitors and can, inter alia, be used in the treatment of various proliferative diseases.

专利号:CN-107663161-A
优先权日:2016-07-27
标 题 :A kind of continuous flow synthesis process of phenylhydrazine salt and substituted phenylhydrazine salt

专利号:CN-110950848-B
优先权日:2018-09-27
标题 :Synthesis and Application of New Aminopyrazole Derivatives