6-氨基喹啉置于tetrafluoroboric Acid,Sodium Nitrite体系中,化学反应生成 6-氟喹啉 参考文献:The Preparation Of Heterocyclic Fluorine Compounds By The Schiemann Reaction. Ii. The Monofluoroquinolines 标题:The Preparation Of Heterocyclic Fluorine Compounds By The Schiemann Reaction. Ii. The Monofluoroquinolines 摘要: DOI:10.1021/ja01173A072
专利号:US-6166031-A 优先权日:1987-10-19 标 题:Substituted tetralins, chromans and related compounds in the treatment of asthma 发明人:EGGLER JAMES F; MARFAT ANTHONY; MELVIN JR LAWRENCE S 权利人:PFIZER 摘要:Substituted tetralins, chromans and related compounds which, by inhibiting 5-lipoxygenase enzyme and/or blocking leukotriene receptors, are useful in the prevention or treatment of asthma, arthritis, psoriasis, ulcers, myocardial infarction and related disease states in mammals; pharmaceutical compositions comprising said compounds; a method of treatment with said compounds; and intermediates useful in the synthesis of said compounds.
专利号:US-5656634-A 优先权日:1991-03-21 标题 :N-aryl and N-heteroarylamide and urea derivatives as inhibitors of acyl coenzyme A: cholesterol acyl transferase (ACAT) 发明人:CHANG GEORGE; HAMANAKA ERNEST S; MCCARTHY PETER A; TRUONG THIEN V; WALKER FREDERICK J 权利人:PFIZER 摘要:Compounds of the formula ##STR1## the pharmaceutically acceptable salts thereof, wherein Q and R 1 are as defined below, and novel carboxylic acid and acid halide intermediates used in the synthesis of such compounds. The compounds of formula I are inhibitors of acyl coenzyme A: cholesterol acyltransferase (ACAT) and are useful as hypolipidemic and antiatherosclerosis agents.
专利号:US-5998451-A 优先权日:1987-10-19 标 题 :Substituted tetralins, chromans and related compounds in the treatment and related compounds in the treatment of asthma, arthritis and related diseases 发明人:EGGLER JAMES F; MARFAT ANTHONY; MELVIN JR LAWRENCE S 权利人:PFIZER 摘要:Substituted tetralins, chromans and related compounds which, by inhibiting 5-lipoxygenase enzyme and/or blocking leukotriene receptors, are useful in the prevention or treatment of asthma, arthritis, psoriasis, ulcers, myocardial infarction and related disease states in mammals, pharmaceutical compositions thereof, a method of treatment therewith, and to intermediates useful in the synthesis thereof.
专利号:CN-108503582-A 优先权日:2018-01-19 标 题:Microwave Assisted Synthesis of 2-(1H)-Quinolinones
专利号:CN-115433125-A 优先权日:2022-09-15 标题 :A new method for the synthesis of 2-tert-butoxyquinoline derivatives