CAS: 396-30-5; 6-Fluoroquinoline

该化合物是一种环环环化合物,其特点是包括苯环和环在内的双环结构引信;在奎诺林环系统6处放置的氟原子,其化学特性和反应作用受到显著影响;该化合物一般是一种黄褐色至浅褐色液体或固体,其形态和纯度取决于其灰色至浅褐色液体或固体;它具有在药用化学中的潜在用途,特别是用于研制抗微生物和抗病毒剂的脚架;氟基亚元素可增强亲性和生物利用率,使其在药物设计中成为有价值的改变.此外,6氟基物质具有荧光特性,在各种分析应用中可能有用.其合成过程通常涉及quino衍生物或其他合成途径的氟化,从而在理想位置引入氟化原子.与许多氟化化合物一样,由于潜在的毒性和环境考虑,它对于处理六氟基线至关重要.

结构式图片

相似化合物

396-31-6 145241-75-4 394-68-3

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合成工艺路线路线简述

    6-氨基喹啉置于tetrafluoroboric Acid,Sodium Nitrite体系中,化学反应生成 6-氟喹啉
    参考文献:The Preparation Of Heterocyclic Fluorine Compounds By The Schiemann Reaction. Ii. The Monofluoroquinolines
    标题:The Preparation Of Heterocyclic Fluorine Compounds By The Schiemann Reaction. Ii. The Monofluoroquinolines
    摘要:
    DOI:10.1021/ja01173A072

    海关参考信息

    专利信息


    专利号:US-6166031-A
    优先权日:1987-10-19
    标 题:Substituted tetralins, chromans and related compounds in the treatment of asthma
    发明人:EGGLER JAMES F; MARFAT ANTHONY; MELVIN JR LAWRENCE S
    权利人:PFIZER
    摘要:Substituted tetralins, chromans and related compounds which, by inhibiting 5-lipoxygenase enzyme and/or blocking leukotriene receptors, are useful in the prevention or treatment of asthma, arthritis, psoriasis, ulcers, myocardial infarction and related disease states in mammals; pharmaceutical compositions comprising said compounds; a method of treatment with said compounds; and intermediates useful in the synthesis of said compounds.

    专利号:US-5656634-A
    优先权日:1991-03-21
    标题 :N-aryl and N-heteroarylamide and urea derivatives as inhibitors of acyl coenzyme A: cholesterol acyl transferase (ACAT)
    发明人:CHANG GEORGE; HAMANAKA ERNEST S; MCCARTHY PETER A; TRUONG THIEN V; WALKER FREDERICK J
    权利人:PFIZER
    摘要:Compounds of the formula ##STR1## the pharmaceutically acceptable salts thereof, wherein Q and R 1 are as defined below, and novel carboxylic acid and acid halide intermediates used in the synthesis of such compounds. The compounds of formula I are inhibitors of acyl coenzyme A: cholesterol acyltransferase (ACAT) and are useful as hypolipidemic and antiatherosclerosis agents.

    专利号:US-5998451-A
    优先权日:1987-10-19
    标 题 :Substituted tetralins, chromans and related compounds in the treatment and related compounds in the treatment of asthma, arthritis and related diseases
    发明人:EGGLER JAMES F; MARFAT ANTHONY; MELVIN JR LAWRENCE S
    权利人:PFIZER
    摘要:Substituted tetralins, chromans and related compounds which, by inhibiting 5-lipoxygenase enzyme and/or blocking leukotriene receptors, are useful in the prevention or treatment of asthma, arthritis, psoriasis, ulcers, myocardial infarction and related disease states in mammals, pharmaceutical compositions thereof, a method of treatment therewith, and to intermediates useful in the synthesis thereof.

    专利号:CN-108503582-A
    优先权日:2018-01-19
    标 题:Microwave Assisted Synthesis of 2-(1H)-Quinolinones

    专利号:CN-115433125-A
    优先权日:2022-09-15
    标题 :A new method for the synthesis of 2-tert-butoxyquinoline derivatives

    专利号:CN-108503582-B
    优先权日:2018-01-19
    标 题:Microwave-assisted synthesis method of 2- (1H) -quinolinone compounds
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    合成参考文献


    摘要:Vrána, J.; Růžička, A., Science of Synthesis Knowledge Updates, (2021) 2, 45.
    摘要:Sharma, U.; Kumar, R.; Gupta, S. S.; Chandra, D., Science of Synthesis Knowledge Updates, (2022) 2, 73.
    摘要:Sharma, U.; Kumar, R.; Gupta, S. S.; Chandra, D., Science of Synthesis Knowledge Updates, (2022) 2, 69.
    摘要:Sharma, U.; Kumar, R.; Gupta, S. S.; Chandra, D., Science of Synthesis Knowledge Updates, (2022) 2, 310.
    摘要:Sharma, U.; Kumar, R.; Gupta, S. S.; Chandra, D., Science of Synthesis Knowledge Updates, (2022) 2, 205.
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