CAS: 40161-54-4; 1-Bromo-2-Fluoro-4-(Trifluoromethyl)Benzene

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CAS号402-07-3 2-溴-5-三氟甲基苯甲醚 | CAS号847547-01-7 4-(2-Fluoro-4-t...

4-溴-3-氟苯酚置于bis(1,5-Cyclooctadiene)Nickel (0),三乙胺,三甲基膦体系中,用 1,4-二氧六环,二氯甲烷 作为反应溶剂,化学反应 9.17H,反应生成 4-溴-3-氟三氟甲苯
参考文献:通过 Ar-O 和 Ar-Cl(Br) 键的化学选择性断裂,镍介导的氯化和溴化苯酚衍生物的发散性三氟甲基化
标题:通过 Ar-O 和 Ar-Cl(Br) 键的化学选择性断裂,镍介导的氯化和溴化苯酚衍生物的发散性三氟甲基化
摘要:我们在此报道了镍介导的氯化和溴化苯酚衍生物 Clarots 和 Brarotf 的三氟甲基化通过 Ar-O 键的化学选择性断裂得到氯(溴)三氟甲基芳烃.此外,在相似的反应条件下,Claropiv和brarots的ar-Cl和ar-Br键发生化学选择性三氟甲基化,得到三氟甲基化苯酚衍生物.
DOI:10.1021/acs.Orglett.4C03020

专利信息

专利号:US-2024309003-A1
优先权日:2021-05-04
标题 :Heterocyclic compounds as triggering receptor expressed on myeloid cells 2 agonists and methods of use
发明人：HOUZE JONATHAN B; BOS MAXENCE; MANCUSO JOHN; FRANZONI IVAN; PANDYA BHAUMIK; KAPLAN ALAN
权利人:VIGIL NEUROSCIENCE INC
摘要:The present disclosure provides compounds of Formula I, useful for the activation of Triggering Receptor Expressed on Myeloid Cells 2 (“TREM2â€?). This disclosure also provides pharmaceutical compositions comprising the compounds, uses of the compounds, and compositions for treatment of, for example, a neurodegenerative disorder. Further, the disclosure provides intermediates useful in the synthesis of compounds of Formula I.

专利号:US-2010120784-A1
优先权日:2007-04-20
标题 :Novel heteroaromatic compounds as inhibitors of stearoyl-coenzyme a delta-9 desaturase
发明人：LACHANCE NICOLAS; LI CHUN SING; LECLERC JEAN-PHILPPE; RAMTOHUL YEEMAN K
权利人:LACHANCE NICOLAS; LI CHUN SING; LECLERC JEAN-PHILPPE; RAMTOHUL YEEMAN K
摘要:Heteroaromatic compounds of structural formula (I) or a pharmaceutically acceptable salt thereof, wherein W is a substituted heteroaryl, X and Y are each independently a bond, —O—, —S—, —S(O)—, —S(O) 2 —, —NR 6 —, —C(O)—, —C(CH 3 )(OH)— or —C(CH 3 )â•?CH—, u (I) is an integer from 1 to 4, and Ar is an optionally substituted phenyl or naphtyl, are inhibitors of stearoyl-coenzyme A delta-9 desaturase (SCD) The compounds of the present invention are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease, such as atherosclerosis, obesity, Type 2 diabetes, insulin resistance, hyperglycemia, Metabolic Syndrome, neurological disease, cancer, and liver steatosis