CAS: 620-79-1; Ethyl 2-Benzyl-3-Oxobutanoate

上下游产品

dibenzyl ether ethyl acetoacetate benzyl chloride benzyldimethylphenylammonium chloride2,2-dibenzyl-acetoacetic acid ethyl ester 2-(2-Methyl-1,3-dioxolanyl)-3-phenyl-propansaeureethylester 2-acetyl-2-benzyl-succinic acid diethyl ester 3-benzyl-5-hydroxy-4,7-dimethyl-coumarin

苯基丙酮置于三氟化硼乙醚,Lithium Diisopropyl Amide体系中,用 四氢呋喃,正己烷 作为反应溶剂,化学反应 0.17H,反应生成 2-苄基乙酰乙酸乙酯
参考文献:α-重氮-β-羟基酯与三氟化硼醚的反应:不稳定乙烯基阳离子的反应生成和重排.详细的实验和理论研究
标题:α-重氮-β-羟基酯与三氟化硼醚的反应:不稳定乙烯基阳离子的反应生成和重排.详细的实验和理论研究
摘要:通过用 Lda 处理重氮乙酸乙酯,然后与一系列环酮反应来制备环状 2-重氮-3-羟基羧酸乙酯.在各种溶剂中用三氟化硼醚合物进一步处理这些 α-重氮-β-羟基酯,可得到一系列不寻常的产品.发现产品类型和比例很大程度上取决于环大小和所用溶剂.该反应通过重氮羟基酯的醇官能团与 Bf3 醚合物的路易斯酸络合进行,然后重氮部分的相邻基团参与反应生成亚环烷基重氮盐.氮的损失会产生高反应性,不稳定的线性乙烯基阳离子.通过 1,2-亚甲基位移的扩环导致形成更稳定的弯曲环烯基乙烯基阳离子.随后的 1,2-亚甲基位移导致环收缩,最终形成稳定的烯丙基阳离子.该阳离子要么被溶剂捕获,要么与相邻的离子发生环化...
DOI:10.1021/ja950971S

专利信息

专利号:US-4891442-A
优先权日:1987-03-09
标 题 :Process for synthesis of β-phenylalanine
发明人：LIN JIANG-JEN; KNIFTON JOHN F
权利人:TEXACO INC
摘要:N-acetyl-β-phenylalanine is synthesized by reacting phenylacetaldehyde, acetamide and synthesis gas with a catalyst comprising a cobalt-containing compound in conjunction with a cocatalyst that may be either a Group VB or VIB containing ligand, or a rhodium compound optionally bonded to one or more Group VB or VIB donor ligands, at a temperature of at least 50° C. and a pressure of at least 500 psi.

专利号:US-8257931-B2
优先权日:2005-01-21
标题 :Regulation of protein synthesis
发明人：WAGNER GERHARD; CHOREV MICHAEL; MOERKE NATHAN JOHN; AKTAS BERTAL HUSEYIN; HALPERIN JOSE
权利人:WAGNER GERHARD; CHOREV MICHAEL; MOERKE NATHAN JOHN; AKTAS BERTAL HUSEYIN; HALPERIN JOSE; HARVARD COLLEGE
摘要:A composition and method for inhibiting proliferation of a tumor cell compared to a non-tumor cell. Also described are methods of screening for a composition that inhibits cap-dependent translation compared to cap-independent translation of proteins.

专利号:CA-1296356-C
优先权日:1987-03-09
标题 :PROCESS FOR SYNTHESIS OF .beta.-PHENYLALANINE

专利号:EP-0281707-A2
优先权日:1987-03-09
标题 :Process for synthesis of beta-phenylalanine

专利号:US-2005113397-A1
优先权日:2002-01-31
标题:Imidazo[1,2-a]pyridine derivative
发明人：TAKEMURA MAKOTO; TAKAHASHI HISASHI; KAWAKAMI KATSUHIRO; TAKESHITA HIROSHI; KIMURA YOUICHI; WATANABE JUN; SUGIMOTO YUICHI; KITAMURA AKIHIRO; NAKAJIMA RYOHEI; KANAI KAZUO; FUJISAWA TETSUNORI
摘要:A compound reprsented by the following formula (I), its salts or nsolvates thereof capable of specifically or selectively expressig an antifungal activity in a broad spectrum based on the novel mechanism thereof of 1,6-β-glucan synthesis inhibition, and an antifungal agent containing any of them.

专利号:US-2007191395-A1
优先权日:2004-02-16
标题 :Heterocyclic compounds having antifungal activity
发明人：KAWAKAMI KATSUHIRO; KANAI KAZUO; FUJISAWA TETSUNORI; MORITA CHIKANORI; SUZUKI TAKASHI
权利人:KAWAKAMI KATSUHIRO; KANAI KAZUO; FUJISAWA TETSUNORI; MORITA CHIKANORI; SUZUKI TAKASHI
摘要:A compound which can specifically or selectively expresses an antifungal activity with a broad spectrum, based on the functional mechanism of 1,6-β-glucan synthesis inhibition, is provided, and an antifungal agent which comprises such a compound, a salt thereof or a solvate thereof is provided. A compound represented by the following formula (I), a salt thereof or a solvate thereof.