CAS: 641571-11-1; 3-(4-Methyl-1H-Imidazol-1-yl)-5-(Trifluoromethyl)Aniline

上下游产品

4-methyl-1H-imidazole [3-bromo-5-(trifluoromethyl)phenyl]amine 4-methyl-1-(3-nitro-5-(trifluoromethyl)-phenyl)-1H-imidazole 3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline hydr°Chloride 6-methyl-N-{3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl}-5-[4-(pyrid-3-yl)pyrimid-2-yl-amino]nicotinamide 3-iodo-4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl]benzamide nilotinib 6-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl]-1-naphthalenecarboxamide

三氟甲苯置于盐酸,Copper(L) Iodide,硫酸,溴,硝酸,D-Glucosamine Hydrochloride,铁粉,Caesium Carbonate体系中,用 乙醇,水,二甲基亚砜 作为反应溶剂,化学反应 17.5H,反应生成 3-(4-甲基-1H-咪唑-1-基)-5-(三氟甲基)苯胺
参考文献:一种用于c-x偶联的高效基于d-氨基葡萄糖的铜催化剂及其在尼罗替尼中间体的合成中的应用†
标题:一种用于c-x偶联的高效基于d-氨基葡萄糖的铜催化剂及其在尼罗替尼中间体的合成中的应用†
摘要:已经通过氮和硫亲核试剂与芳基碘化物和溴化物的交叉偶联反应研究了d-氨基葡萄糖的c-n和c-s键的形成.咪唑,苯并咪唑,吲哚,吡咯烷和二苯基二硫化物在10摩尔%d-葡萄糖胺,10摩尔%cui和2当量的存在下与芳基卤化物发生反应.dmso-h 2中的cs 2 Co 3浓度在中等温度下o可得到相应的产物,收率非常好至极佳.具有卤化物,游离氨基,三氟甲基和杂环的底物具有非常好的耐受性.配体的高水溶性使其易于去除催化剂.此外,使用市售底物也成功证明了该催化体系在尼罗替尼中间体合成中的应用.
DOI:10.1039/c4Ra11183D

专利信息

专利号:US-7709657-B2
优先权日:2005-06-09
标 题:Process for the synthesis of organic compounds
发明人：ACEMOGLU MURAT; SCHENKEL BERTHOLD; SHIEH WEN-CHUNG; XUE SONG; WIDMER ERICH; GARCIA FUENTES PEDRO; MARTIN MEDINA JOSE; VICENTE BANOS FRANCISCO
权利人:NOVARTIS AG
摘要:The present invention provides an efficient, safe and cost effective way to prepare 5-(4-methyl-1H-imidazol-1-yl)-3-(trifluoromethyl)-benzenamine which is an intermediate for the preparation of substituted pyrimidinylaminobenzamides of formula (II):

专利号:US-11414388-B2
优先权日:2018-04-10
标 题:Crystal form of 3-(4-methyl-1h-imidazol-1-yl)-5-trifluoromethylaniline monohydrochloride and use thereof
发明人：NIU DELIANG; MA BOJUN; ZHU ZHANQUN; WAN QIANG
权利人:ARIZEST SHANGHAI PHARMATECH CO LTD; JIANGSU XIDI PHARMACEUTICALS CO LTD; SHANGHAI ACEBRIGHT PHARMACEUTICALS GROUP CO LTD
摘要:The present invention relates to a crystal form of 3-(4-methyl-1H-imidazol-1-yl)-5-trifluoromethylaniline monohydrochloride and the use thereof. Specifically, disclosed are a crystal form A of a monohydrochloride anhydrous substance of 3-(4-methyl-1H-imidazol-1-yl)-5-trifluoromethylaniline monohydrochloride, a method for preparing the crystal form A and the use of the crystal form in the synthesis of nilotinib. The crystal form A of the present invention has good stability and purity, and can be directly used in the preparation and production of nilotinib. The method for preparing nilotinib in the present invention is easy to operate and has high industrial application value.

专利号:US-8008504-B2
优先权日:2005-06-09
标题 :Process for the synthesis of organic compounds
发明人：ABEL STEPHAN; ACEMOGLU MURAT; ERB BERNHARD; KRELL CHRISTOPH; SCLAFANI JOSEPH; MEISENBACH MARK; PRASHAD MAHAVIR; SHIEH WEN-CHUNG; XUE SONG
权利人:NOVARTIS AG
摘要:The present invention provides an efficient, safe and cost effective way to prepare 5-(4-methyl-1H-imidazol-1-yl)-3-(trifluoromethyl)-benzenamine which is a key intermediate for the preparation of substituted pyrimidinylaminobenzamides of formula (II):

专利号:US-8946416-B2
优先权日:2005-06-09
标 题:Process for the synthesis of 5-(methyl-1H-imidazol-1-yl)-3-(trifluoromethyl)-benzeneamine
发明人：SHIEH WEN-CHUNG; MCKENNA JOSEPH
权利人:SHIEH WEN-CHUNG; MCKENNA JOSEPH; NOVARTIS AG
摘要:The present invention provides a new method of making compounds of formula (I): n nwhereinn R1 is mono- or polysubstituted aryl; R2 is hydrogen, lower alkyl or aryl; and R4 is hydrogen, lower alkyl or halogen.

专利号:US-2023065387-A1
优先权日:2019-10-14
标题:Synthesis of tyrosine kinase inhibitors

专利号:US-2008188656-A1
优先权日:2005-06-09
标 题 :Process for the Synthesis of 5- (Methyl-1H-Imidazol-1-Yl) -3- (Trifluoromethyl) -Benzeneamine