缩水甘油丁酯 以 四氢呋喃 作为反应溶剂,以44%的收率获得产物(S)-丁酸缩水甘油酯 参考文献:Practical Access To Highly Enantioenriched C-3 Building Blocks Via Hydrolytic Kinetic Resolution 标题:Practical Access To Highly Enantioenriched C-3 Building Blocks Via Hydrolytic Kinetic Resolution 摘要: DOI:10.1021/jo981332D
专利号:US-9233989-B2 优先权日:2011-10-11 标题:Sila analogs of oxazolidinone derivatives and synthesis thereof 发明人:REDDY DUMBALA SRINIVASA; BALAMKUNDU SEETHARAM SINGH; RAMESH REMYA 权利人:COUNCIL SCIENT IND RES 摘要:The invention discloses silaanalogs of oxazolidinone compounds, to pharmaceutical compositions and to the synthesis of the oxazolidinone derivatives of formula I. The invention further relates to methods of treating a subject suffering with gram positive pathogens including those resistant to methicillin and vancomycin using the compound(s) or modulation of coagulation properties of blood-clotting cascade or compositions of the oxazolidinone derivatives of the invention.
专利号:US-9376400-B2 优先权日:2005-06-08 标 题:Process for the synthesis of triazoles 发明人:CHEN SHILI; LOU RONGLIANG; WU YUSHENG; ZHOU JIACHENG; HANSELMANN ROGER 权利人:MELINTA THERAPEUTICS INC 摘要:The present invention relates to processes for the preparation of triazoles. These compounds are useful as anti-infective, anti-proliferative, anti-inflammatory, and prokinetic agents.
专利号:US-8895741-B2 优先权日:2003-06-03 标 题:Process for the synthesis of biaryl oxazolidinones 发明人:WU YUSHENG; CHEN SHILI; CHEN YI; HANSELMANN ROGER; LOU RONGLIANG; ZHOU JIACHENG 权利人:WU YUSHENG; CHEN SHILI; CHEN YI; HANSELMANN ROGER; LOU RONGLIANG; ZHOU JIACHENG; MELINTA THERAPEUTICS INC 摘要:The present invention relates to processes for the preparation of biaryl oxazolidinones. These compounds are useful as anti-infective, anti-proliferative, anti-inflammatory, and prokinetic agents.
专利号:US-6743811-B2 优先权日:1999-07-28 标 题:Oxazalidinone compounds and methods of preparation and use thereof 发明人:GORDEEV MIKHAIL F; LUEHR GARY W; PATEL DINESH V; GADWOOD ROBERT C 权利人:UPJOHN CO 摘要:Oxazolidinones and methods for their synthesis are provided. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. Oxazolidinones as disclosed herein can be readily synthesized and used in a variety of applications including use as antimicrobial agents. In one embodiment, a variety of thioamidomethyloxazolidinones and methods for their synthesis and use are provided.
专利号:US-6531470-B1 优先权日:1998-01-23 标题:Oxazolidinone combinatorial libraries, compositions and methods of preparation 发明人:GORDEEV MIKHAIL F; LUEHR GARY W; PATEL DINESH V; NI ZHI-JIE; GORDON ERIC 权利人:UPJOHN CO 摘要:Oxazolidinones and methods for their synthesis are provided. Also provided are combinatorial libraries comprising oxazolidinones, and methods to prepare the libraries. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. The methods of library preparation include the attachment of oxazolidinones to a solid support. The methods of compound preparation in one embodiment involve the reaction of an iminophosphorane with a carbonyl containing polymeric support.
专利号:US-7220870-B2 优先权日:1995-03-14 标 题:Hydrolytic kinetic resolution of cyclic substrates 发明人:JACOBSEN ERIC N; TOKUNAGA MAKOTO; LARROW JAY F 权利人:HARVARD COLLEGE 摘要:The present invention relates to a process for stereoselective or regioselective chemical synthesis which generally comprises reacting a nucleophile and a chiral or prochiral cyclic substrate in the presence of a non-racemic, chiral catalyst to produce a stereoisomerically- and/or regioisomerically-enriched product. The present invention also relates to hydrolytic kinetic resolutions of racemic and diastereomeric mixtures of epoxides.
[参考文献]: Arnaldo Glogauer, Et Al. Identification And Characterization Of A New True Lipase Isolated Through Metagenomic Approach. Microb Cell Fact. 2011 Jul 15:10:54.
合成参考文献
参考文献:10.1186/1475-2859-10-54 摘要:Glogauer A, Martini VP, Faoro H, Couto GH, Müller-Santos M, Monteiro RA, Mitchell DA, de Souza EM, Pedrosa FO, Krieger N. Identification and characterization of a new true lipase isolated through metagenomic approach. Microbial Cell Factories. 2011 Jul 15;10(1):54. doi: 10.1186/1475-2859-10-54.