CAS: 673-22-3; 2-Hydroxy-4-Methoxybenzaldehyde

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CAS号77-78-1 硫酸二甲酯 | CAS号95-01-2 2,4-二羟基苯甲醛 | CAS号613-45-6 2,4-二甲氧基苯甲醛 | CAS号50-00-0 甲醛 | CAS号150-19-6 3-甲氧基苯酚 | CAS号74-88-4 碘甲烷 | CAS号40138-18-9 2-醛基-5-甲氧基苯硼酸 | CAS号954374-77-7 ethyl (E)-3-(2-... | CAS号106-49-0 对甲苯胺 | CAS号74-83-9 溴甲烷 | CAS号108530-10-5 三氟甲磺酸2-氧代-2H-色满-7-基酯 | CAS号107811-48-3 2-异丙氧基-4-甲氧基苯甲醛 | CAS号3722-56-3 (S)-4′,7-二甲基麦角酚 | CAS号50551-61-6 6-甲氧基苯并呋喃-2-羧酸 | CAS号39835-11-5 2-羟基-4-甲氧基苯甲腈 | CAS号50551-63-8 6-甲氧基苯并呋喃 | CAS号4107-65-7 2,4-二甲氧基苯甲腈 | CAS号484-12-8 蛇床子素 | CAS号42327-52-6 7-甲氧基-4H-1-苯并吡喃-4-酮 | CAS号208842-22-2 (6-Methoxy-1-be...

4-甲氧基水杨酸置于palladium On Barium Sulfate 吡啶,喹啉,氯化亚砜,氢气,Sulfur体系中,用 甲苯,Petroleum Ether 作为反应溶剂,化学反应生成 2-羟基-4-甲氧基苯甲醛
参考文献:Coumarins. Iii. A Novel Synthesis Ofo-Hydroxybenzaldehydes
标题:Coumarins. Iii. A Novel Synthesis Ofo-Hydroxybenzaldehydes
摘要:在温和温度下,水杨酰氯的催化氢化反应获得了高产率的水杨醛.对取代水杨酰氯进行类似的部分还原也获得了相应的水杨醛,产率可观.然而,尝试制备其他异构体羟基苯酰氯却未能成功.文中讨论了水杨酰氯的结构与其转化为水杨醛的难易程度之间的关系.此外,还描述了用二氯甲基甲醚对 Phenol 进行甲酰化的过程以及选择性 Ortho-甲酰化的相关信息.
DOI:10.1246/bcsj.40.1428

专利信息

专利号:US-7589170-B1
优先权日:1998-09-25
标题 :Synthesis of cyclic peptides
发明人：SMYTHE MARK LESLIE; MEUTERMANS WIM DENIS FRANS; BOURNE GREGORY THOMAS; MCGEARY ROSS PETER
权利人:UNIV QUEENSLAND
摘要:This invention relates to methods for preparing cyclic peptides and peptidomimetic compounds in solution and bound to solid supports, and to cyclic peptide or peptidomimetic libraries for use in drug screening programs. In particular, the invention relates to a generic strategy for synthesis of cyclic peptides or peptidomimetics that enables the efficient synthesis under mild conditions of a wide variety of desired compounds. Two approaches were evaluated for their improvements in solution and solid phase synthesis of small cyclic peptides: positioning reversible N-amide substituents in the sequence; and applying native ligation chemistry in an intramolecular sense. Systematic investigation of the effects of preorganising peptides prior to cyclisation by using peptide cyclisation auxiliaries, and developing new linkers and peptide cyclisation auxiliaries to aid cyclic peptide synthesis gives surprising improvements in both yields and purity of products compared to the prior art methods. The combination of these technologies provides a powerful generic approach for the solution and solid phase synthesis of small cyclic peptides. The ring contraction and N-amide substitution technology of the invention provide improved methods for the synthesis of cyclic peptides and peptidomimetics. When used in conjunction with linker strategies, this combination provides solid-phase avenues to cyclic peptides and peptidomimetics.

专利号:WO-2024174680-A1
优先权日:2023-02-24
标题:Building blocks for difficult peptide synthesis and method of making thereof
发明人：LI XUECHEN; WU HONGXIANG; SUN ZHENQUAN
权利人:VERSITECH LTD
摘要:Building block structures containing N, O/S-benzylidene acetal dipeptide (NBD) are described. The unique core structure of NBD can effectively convert those difficult peptide/proteins sequence into the easy ones, allowing smooth synthesis of those challenging targets. Further, the production of NBDs is highly robust, and it can be scale up facilely, which can facilitate the research and development of tailor-made peptides/proteins in the future.

专利号:US-5175302-A
优先权日:1987-07-13
标 题 :Nucleophilic fluoroalkylation of aldehydes
发明人：STAHLY G PATRICK
权利人:ETHYL CORP
摘要:Aryl difluoromethyl sulfone adds to aldehydes under phase transfer conditions to give novel substituted alcohols of the general formula n n RCH(OH)CF.sub.2 SO.sub.2 Ar (I) n n wherein R is an aryl, cycloaliphatic, sec- or tert-aliphatic, or heterocyclic group and Ar is an aryl group. The substituted alcohols of formula I are of particular utility as intermediates in the synthesis of a variety of useful end products. For example, the products of formula I may be utilized in desulfonylation reactions, oxidation reactions and fluorination reactions.

专利号:US-4837327-A
优先权日:1987-07-13
标 题 :Process for nucleophilic fluoroalkylation of aldehydes
发明人：STAHLY G PATRICK
权利人:ETHYL CORP
摘要:Aryl difluoromethyl sulfone adds to alkehydes under phase transfer conditions to give novel substituted alcohols of the general formula n n RCH(OH)CF.sub.2 SO.sub.2 Ar (I) n n wherein R is an aryl, cycloaliphatic, sec- or tert-aliphatic, or heterocyclic group and Ar is an aryl group. The substituted alcohols of formula I are of particular utility as intermediates in the synthesis of a variety of useful end products. For example, the products of formula I may be utilized in desulfonylation reactions, oxidation reactions and fluorination reactions.

专利号:US-4999429-A
优先权日:1989-01-09
标 题 :Process for the preparation of α,α,β-1-trifluoro-1-olefinic derivatives
发明人：STAHLY G PATRICK
权利人:ETHYL CORP
摘要:Aryl difluoromethyl sulfone adds to aldehydes under phase transfer conditions to give novel substituted alcohols of the general formula n n RCH(OH)CF.sub.2 SO.sub.2 Ar (I) n n wherein R is an aryl, cycloaliphatic, sec- or tert-aliphatic, or heterocyclic group and Ar is an aryl group. The substituted alcohols of formula I are of particular utility as intermediates in the synthesis of a variety of useful end products. For example, the products of formula I may be utilized in desulfonylation reactions, oxidation reactions and fluorination reactions.

专利号:US-7718598-B1
优先权日:1998-09-25
标 题:Auxiliary for amide bond formation
发明人：SMYTHE MARK LESLIE; MEUTERMANS WIM DENIS FRANS
权利人:UNIV QUEENSLAND
摘要:This invention relates to methods for preparing cyclic peptides and peptidomimetic compounds in solution and bound to solid supports, and to cyclic peptide or peptidomimetic libraries for use in drug screening programmes. In particular, the invention relates to a generic strategy for synthesis of cyclic peptides or peptidomimetics that enables the efficient synthesis under mild conditions of a wide variety of desired compounds. Two approaches were evaluated for their improvements in solution and solid phase synthesis of small cyclic peptides: positioning reversible N-amide substituents in the sequence; and applying native ligation chemistry in an intramolecular sense. Systematic investigation of the effects of preorganizing peptides prior to cyclisation by using peptide cyclisation auxiliaries, and developing new linkers and peptide cyclisation auxiliaries to aid cyclic peptide synthesis gives surprising improvements in both yields and purity of products compared to the prior art methods. The combination of these technologies provides a powerful generic approach for the solution and solid phase synthesis of small cyclic peptides. The ring contraction and N-amide substitution technology of the invention provide improved methods for the synthesis of cyclic peptides and peptidomimetics. When used in conjunction with linker strategies, this combination provides solid-phase avenues to cyclic peptides and peptidomimetics.