CAS: 6780-38-7; 2-(1,3-Dioxoisoindolin-2-yl)Acetyl Chloride

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CAS号4702-13-0 邻苯二甲酰甘氨酸 | CAS号5292-43-3 溴乙酸叔丁酯 | CAS号108-42-9 间氯苯胺 | CAS号85-44-9 苯酐 | CAS号22509-74-6 N-乙氧羰基邻苯二甲酰亚胺 | CAS号10026-13-8 五氯化磷 | CAS号3416-57-7 邻苯二甲酰亚胺基丙酮 | CAS号3705-27-9 环(甘氨酸-L-脯氨酸)二肽 | CAS号4702-13-0 邻苯二甲酰甘氨酸 | CAS号21313-49-5 邻苯二甲酰甘氨酸4-硝基苯酯 | CAS号2017-94-9 2-(1,3-dioxoiso... | CAS号2641-02-3 ethyl 2-[[2-(1,... | CAS号2756-76-5 ethenyl 2-(1,3-... | CAS号2913-97-5 N-(2-乙醛基)-邻苯二甲酰亚胺 | CAS号23244-58-8 2-(1,3-二氧代异吲哚啉-... | CAS号131338-51-7 2-[[6-bromo-3-(...

邻苯二甲酰甘氨酸置于氯化亚砜体系中,用 苯 作为反应溶剂,化学反应 3.0H,反应生成 N-邻苯二甲酰甘氨酰氯
参考文献:基于功能化烯丙酸酯的吡唑类化合物的合成
标题:基于功能化烯丙酸酯的吡唑类化合物的合成
摘要:证明了在三乙胺存在下,通过重氮甲烷与烯丙酸酯的 1,3-偶极环加成,区域特异性合成 Pyrazole-3-Carboxylate 衍生物.在超声条件下探索了烯丙酸酯与含有重氮酮的硬脂酸部分的反应.吡唑的新型衍生物以优异的产率获得.引言 在含氮杂环骨架的化合物中,吡唑是各种生物活性分子最有用的结构单元之一.这些化合物的生物活性已被广泛用作抗糖尿病,抗病毒,抗菌,抗菌,抗癌剂.除了它们的生物学重要性外,吡唑还作为催化剂,分子磁性器件和传感器发挥重要作用.1,重氮化合物与双键和三键的 3-偶极环加成反应是众所周知的并且有文献记载.相比之下,包括这种关于丙二烯的方法的研究受到的关注要少得多.考虑到带有吡唑部分的化合物的生物活性,我们计划从功能化的烯丙酸酯合成一系列吡唑衍生物.结果与讨论 Allenoates 2A-F 从 N-邻苯二甲酰氨基酸 1A-C 和脂肪酸 1D-F 中获得.亚硫酰氯用于将酸
DOI:10.3987/com-13-12910

专利信息

专利号:WO-8800941-A1
优先权日:1986-08-08
标 题:ASYMETRIC SYNTHESIS OF ENANTIOMERICALLY PURE MONOCLYCLIC beta-LACTAM INTERMEDIATES
发明人：THOMAS RICHARD C
权利人:UPJOHN CO
摘要:Monocyclic beta-lactam intermediates and process for their preparation. The compounds of the present invention are of formula (I), and are useful as intermediate for preparing highly active C-4 substituted monobactams.

专利号:US-4022766-A
优先权日:1974-03-20
标 题:Pharmacologically active pyrrolodiazepines
发明人：FONTANELLA LUIGI; MARIANI LUIGI; TARZIA GIORGIO
权利人:LEPETIT SPA
摘要:Compounds of the following formula wherein R is hydrogen, methyl, ethyl, propyl, isopropyl, butyl, isobutyl, sec.-butyl or tert.-butyl; R1 is hydrogen, methyl, ethyl or phenyl; R2 is hydrogen, methyl, ethyl, propyl, isopropyl, butyl, isobutyl, sec.-butyl or tert.-butyl; R3 is hydrogen, methoxy, trifluoromethyl, chloro, bromo or fluoro; and R4 is methyl. The new compounds are useful as CNS depressants, anticonvulsants, anti-inflammatories and inhibitors of the enzymes which promote the synthesis of prostaglandins.

专利号:EP-0316360-A1
优先权日:1986-08-08
标题 :ASYMETRIC SYNTHESIS OF ENANTIOMERICALLY PURE MONOCLYCLIC $g(b)-LACTAM INTERMEDIATES

专利号:US-5665717-A
优先权日:1993-03-20
标题:Carbacephalosporin compound, their preparation and use
发明人：ELLIOTT RICHARD LEONARD; NICHOLSON NEVILLE HUBERT; TAKLE ANDREW KENNETH
权利人:PFIZER
摘要:Carbacephalosporin compounds of formula (I), ##STR1## salts thereof, processes for their synthesis and uses thereof, wherein: R 1 is hydrogen, methoxy or formamido; R 2 is an acyl group; CO 2 R 3 is a carboxy group or a carboxylate anion, or R 3 is a carboxy protecting group or a pharmaceutically acceptable salt-forming group or in vivo hydrolysable ester group; R 4 , R 5 , R 6 and R 7 represent hydrogen or a substituent; R 4 and R 7 may be replaced by a chemical bond between the two carbon atoms shown; R 5 and R 6 may be linked together into a cyclic system. The compounds (I) have antibacterial properties.

专利号:RU-2076108-C1
优先权日:1990-03-07
标题 :Derivatives of n-phenylglycine amide, method of their synthesis and pharmaceutical composition showing affinity to receptors of hck and gastrin

专利号:US-5183887-A
优先权日:1989-02-02
标 题:Spirocyclic 6-amido-carbapenems and azetidinones
发明人：GREENLEE MARK L; SALZMANN THOMAS N; DININNO FRANK P
权利人:MERCK & CO INC
摘要:New antibacterial spirocyclic 6-amido carbapenems of the structural formulas: wherein R1 is hydrogen, C1-8 substituted or unsubstituted alkyl, or C6-10 substituted or unsubstituted aryl; R5 is hydrogen or a protecting group for alcohol; R6 is hydrogen or a protecting group for amido nitrogen; R7 is hydrogen or a protecting group for amido nitrogen; and R8 is hydroxy, hydrogen, C1-8 substituted or unsubstituted thioalkyl, C6-10 substituted or unsubstituted thioaryl, 5 or 6 membered, substituted or unsubstituted thioheteroaryl; and a process for their synthesis through novel spirocyclic 4-amido azetidinones are disclosed.