CAS: 82846-18-2; 3-Methoxy-4-Fluorobenzoic Acid

该化合物是一种芳烃式的碳酸,其特点是有氟原子和苯环上的甲氧基组,分子结构具有苯酸核心,其中碳酸(-COOH)组附属于芳香环,具体地说,它的位置与氟替代成分和甲基氧组(-OCH3)的元体位置相比是准点,该化合物一般在有机溶剂中表现出中等溶性,由于其防水芳烃结构,水溶性有限,它可能表现出酸性,使其能够参与各种化学反应,包括酯化和核生殖器替代.氟酸组的存在可影响化合物的再活性和极性,而甲基氧组则可能影响其电子特性和胃障碍.4-Fluoro-3-throybenzoic酸在药物和化学研究中可能作为各种生物合成的中间体.

结构式图片

欧盟法规

ECHA物质C&L通报REACH预注册

上下游产品

CAS号74385-37-8 4-氟-3-甲氧基苯甲酸甲酯 | CAS号63762-78-7 2-氟-5-甲基苯甲醚 | CAS号63762-79-8 2-氟-5-甲基苯酚 | CAS号452-84-6 2-氟-5-甲基苯胺 | CAS号51446-31-2 4-氟-3-羟基苯甲酸 | CAS号74385-37-8 4-氟-3-甲氧基苯甲酸甲酯 | CAS号1007455-21-1 2-溴-4-氟-5-甲氧基苯甲酸 | CAS号159768-48-6 4-氯-7-氟-6-甲氧基喹唑啉 | CAS号159768-51-1 2-氨基-4-氟-5-甲氧基苯甲酸甲酯 | CAS号103438-85-3 4-氟-3-羟基苯甲醛 | CAS号128495-45-4 4-氟-3-甲氧基苯甲醇 | CAS号128495-46-5 4-氟-3-甲氧基苯甲醛 | CAS号159768-50-0 4-氟-5-甲氧基-2-硝基苯甲酸甲酯 | CAS号82846-19-3 4-fluoro-3-meth... | CAS号82846-20-6 1-(4-fluoro-3-m...

合成工艺路线路线简述

  • 合成目标产物 4-Fluoro-3-Methoxybenzoic Acid 主要起始原料 Methyl 4-Fluoro-3-Methoxybenzoate
  • 63762-78-7 = 82846-18-2
    反应条件:1.1 Reagents: Pyridine,Permanganic Acid (Hmno4),Potassium Salt (1:1) Solvents: Water
    标题:Synthesis And Dopamine Receptor Affinities Of 2-(4-Fluoro-3-Hydroxyphenyl)Ethylamine And N-Substituted Derivatives
    作者:Claudi,Francesco; Et Al
    参考文献:Journal Of Medicinal Chemistry 日期:1990 卷标:33(9) 页码:2408-12]

    63762-79-8 = 82846-18-2
    反应条件:1.1 Reagents: Dimethyl Sulfate,Potassium Carbonate Solvents: Acetone2.1 Reagents: Pyridine,Permanganic Acid (Hmno4),Potassium Salt (1:1) Solvents: Water
    标题:Synthesis And Dopamine Receptor Affinities Of 2-(4-Fluoro-3-Hydroxyphenyl)Ethylamine And N-Substituted Derivatives
    作者:Claudi,Francesco; Et Al
    参考文献:Journal Of Medicinal Chemistry 日期:1990 卷标:33(9) 页码:2408-12]

    452-84-6 = 82846-18-2
    反应条件:1.1 Reagents: Sodium Nitrite,Sulfuric Acid,Copper Sulfate Solvents: Water2.1 Reagents: Dimethyl Sulfate,Potassium Carbonate Solvents: Acetone3.1 Reagents: Pyridine,Permanganic Acid (Hmno4),Potassium Salt (1:1) Solvents: Water
    标题:Synthesis And Dopamine Receptor Affinities Of 2-(4-Fluoro-3-Hydroxyphenyl)Ethylamine And N-Substituted Derivatives
    作者:Claudi,Francesco; Et Al
    参考文献:Journal Of Medicinal Chemistry 日期:1990 卷标:33(9) 页码:2408-12
4-氟-3-羟基苯甲酸置于水,Potassium Carbonate,Sodium Hydroxide体系中,用 甲醇,N,N-二甲基甲酰胺 作为反应溶剂,化学反应 14.0H,反应生成 4-氟-3-甲氧基苯甲酸
参考文献: Heterocyclic Compounds For The Inhibition Of Pask[fr] Composés Hétérocycliques Pour L'Inhibition De Pask
标题: Heterocyclic Compounds For The Inhibition Of Pask[fr] Composés Hétérocycliques Pour L'Inhibition De Pask
摘要:本文披露了新的杂环化合物和组合物,以及它们作为药物治疗疾病的应用.还提供了抑制pas激酶(pask)在人类或动物主体中活性的方法,用于治疗疾病,如糖尿病.

海关参考信息

专利信息


专利号:US-2023192718-A1
优先权日:2018-03-30
标 题 :Bicyclic enone carboxylates as modulators of transporters and uses thereof
发明人:SANDANAYAKA VINCENT
权利人:NIROGY THERAPEUTICS INC
摘要:The invention generally relates to the field of monocarboxylate transporter inhibitors, and more particularly to new bicyclic enone carboxylate enone compounds, the synthesis and use of these compounds and their pharmaceutical compositions, e.g., in the treatment, modulation and/or prevention of physiological conditions associated with monocarboxylate transporter activity such as in treating cancer and other neoplastic disorders, tissue and organ transplant rejection.

专利号:CN-111727190-A
优先权日:2017-12-28
标题 :A kind of pyridyl imidazobenzodiazepine propionate compound and its synthesis and application

专利号:US-11919905-B2
优先权日:2017-12-28
标题 :Substituted benzo[f]imidazo[1,2-a][1,4]diazepines as anesthetics
发明人:QI YOUMAO
权利人:HANGZHOU ADAMERCK PHARMLABS INC
摘要:Disclosed are a pyridyl imidazobenzodiazepine propionate (compound 1) and the synthesis and use thereof. Also provided are intermediates for the preparation. Compound 1 provided by the present invention has an obvious venous anesthesia activity equivalent to that of the positive control drug remimazolam p-toluenesulfonate or remimazolam besylate. In addition, compound 1 can be significantly reduced in mouse model experiments, and same can even overcome common limb jitters, head tilting, opisthotonus and other side effects caused by the remimazolam besylate or remimazolam p-toluenesulfonate as a drug during development in preclinical animal experiments, thereby allowing same to be used in the preparation of intravenous anesthetics. The structural general formula of compound 1 is as follows, wherein each group and substituent are as defined in the description.

专利号:CN-111727190-B
优先权日:2017-12-28
标题 :A kind of pyridyl imidazobenzodiazepine propionate compound and its synthesis and application

专利号:CN-108033964-B
优先权日:2017-12-28
标 题:A kind of pyridyl imidazobenzodiazepine propionate compound and its synthesis and application
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合成参考文献


参考文献:10.1007/bf00409646
摘要:Kranzfelder G, Hartmann RW, von Angerer E, Schönenberger H, Bogden AE. 3,4-Bis(3′-hydroxyphenyl)hexane — A new mammary tumor-inhibiting compound. Journal of Cancer Research and Clinical Oncology. 1982 May;103(2):165–80. doi: 10.1007/bf00409646.
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