CAS: 90560-10-4; 6-Methoxybenzo[b]Thiophene

该化合物是一种有机化合物,其特征是存在苯并硫苯,由一个引信苯和硫苯环组成;该化合物的特征是附于苯并苯结构第六位置的甲氧基组(-OCH3),影响其化学反应性和溶性;通常,这种性质的化合物具有中度至低极性等特性,使其在有机溶剂中溶解,同时在水中溶解较少;硫苯环的存在可产生独特的电子特性,有可能使其在各种应用中有用,包括有机电子和合成化学中的建筑块;此外,该化合物可能展示生物活动,可能对药物研究感兴趣;其稳定性和再活性可能受到芳香环亚组的影响,并可能发生典型的有机反应,如甲基化,氧化或电药替代.

英文名称6-Methoxybenzo[b]Thiophene
中文名称6-甲氧基苯并噻吩
IUPAC名称6-methoxybenzo[b]thiophene
其它别名6-甲氧基苯并[b]噻吩; 6-Methoxy-1-Benzothiophen
CAS编号90560-10-4
MFCD编号:MFCD13181215
分子式:C9H8OS
分子量:164.22
产品CID: 1938842
产品分类有机原料→分子砌块→芳杂环类化合物→苯并噻吩类化合物

相似结构搜索
InChIKey: WGDVDMKNSDCNGB-UHFFFAOYSA-N
InChI=1S/C9H8OS/c1-10-8-3-2-7-4-5-11-9(7)6-8/h2-6H,1H3…
计算化学: 氢键受体数2.0氢键供体数0.0可旋转键数1.0

MSDS等安全信息

GHS符号GHS07
警示词Warning
危险描述H302-H315-H319-H335
防范说明P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

上下游产品

合成工艺路线路线简述

合成目标产物 6-Methoxybenzo(B)Thiophene 主要起始原料 Benzene, 1-[(2,2-Diethoxyethyl)Thio]-3-Methoxy-
2032-35-1 + 15570-12-4 = 90560-10-4
反应条件:1.1 Reagents: Potassium Carbonate Solvents: Acetone; Rt; 17 H,Rt1.2 Reagents: Boron Trifluoride Etherate Solvents: Dichloromethane; Rt; 30 Min,Rt
标题:Photokinetics Of Two Novel Photochromic Diarylethenes Derived From Benzothiophene
作者:Vazquez,A.; Nudelman,N. Sbarbati
参考文献:International Journal Of Chemical Kinetics 日期:2012 卷标:44(11) 页码:736-744]

17347-32-9 = 90560-10-4
反应条件:1.1 Catalysts: Copper Bromide (Cubr2) Solvents: Methanol,Dimethylformamide; 5 H,110 °C
标题:Enantioselective Hydroarylation Or Hydroalkenylation Of Benzo[b]Thiophene 1,1-Dioxides With Organoboranes
作者:Hu,Fangdong; Jia,Jie; Li,Ximing; Xia,Ying
参考文献:Organic Letters 日期:2021 卷标:23(3) 页码:896-901]

2032-35-1 + 15570-12-4 = 90560-10-4
反应条件:1.1 Reagents: Potassium Carbonate Solvents: Acetone; Rt; 17 H,Rt1.2 Reagents: Boron Trifluoride Etherate Solvents: Dichloromethane; Rt; 30 Min,Rt
标题:Ring Opening/closure Reactions Of Novel Diheteroarylethenes Derivatives. Solvent Effects
作者:Vazquez,Alvaro J.; Nudelman,Norma Sbarbati
参考文献:Journal Of Physical Organic Chemistry 日期:2012 卷标:25(11) 页码:925-932]

2032-35-1 + 15570-12-4 = 90560-10-4
反应条件:1.1 Reagents: Potassium Carbonate Solvents: Acetone1.2 Solvents: Chlorobenzene
标题:Dibasic Benzo[b]Thiophene Derivatives As A Novel Class Of Active Site Directed Thrombin Inhibitors: 4. Sar Studies On The Conformationally Restricted C3-Side Chain Of Hydroxybenzo[b]Thiophenes
作者:Takeuchi,Kumiko; Kohn,Todd J.; Sall,Daniel J.; Denney,Michael L.; Mccowan,Jefferson R.; Et Al
参考文献:Bioorganic & Medicinal Chemistry Letters 日期:1999 卷标:9(5) 页码:759-764]

96803-85-9 = 90560-10-4
反应条件:1.1 Reagents: Boron Trifluoride Etherate Solvents: Dichloromethane; 30 Min,0 °C; 1 H,0 °C; 0 °C -> Rt1.2 Reagents: Sodium Bicarbonate Solvents: Water; Rt
标题:Full Color Light Responsive Diarylethene Inks For Reusable Paper
作者:Jeong,Woomin; Khazi,Mohammed Iqbal; Park,Dong-Hoon; Jung,Young-Sik; Kim,Jong-Man
参考文献:Advanced Functional Materials 日期:2016 卷标:26(29) 页码:5230-5238]

7465-86-3 = 90560-10-4
反应条件:1.1 Reagents: N,N,N′,N′-Tetramethylethylenediamine,Sec-Butyllithium Solvents: Tetrahydrofuran; -78 °C1.2 -1.3 Reagents: Lithium Diisopropylamide Solvents: Tetrahydrofuran; -78 °C1.4 Reagents: Sodium Borohydride Solvents: Methanol
标题:Certain Applications Of Heteroatom Directed Ortho-Metalation In Sulfur Heterocycles
作者:Pradhan,Tarun Kanti; Ghosh,Sukhen Chandra; De,Asish
参考文献:Arkivoc (Gainesville 日期:2003 卷标:(9) 页码:158-173]

5858-22-0 = 90560-10-4
反应条件:1.1 Reagents: Sodium Hydroxide,Sodium Borohydride Solvents: Methanol; 1 H,Reflux; 12 H,Reflux1.2 Reagents: Sulfuric Acid Solvents: Water
标题:Application Of Directed Metalation In Synthesis. Part 4: Expedient Synthesis Of Substituted Benzo[b]Thiophene And Naphthothiophene
作者:Mukherjee,Chandrani; Kamila,Sukanta; De,Asish
参考文献:Tetrahedron 日期:2003 卷标:59(26) 页码:4767-4774]

96803-85-9 = 90560-10-4
反应条件:1.1 Solvents: Chlorobenzene; Overnight,Reflux; Reflux -> Rt
标题:Discovery Of Potent Irreversible Pan-Fibroblast Growth Factor Receptor (Fgfr) Inhibitors
作者:Wang,Yuming; Li,Lijun; Fan,Jun; Dai,Yang; Jiang,Alan; Et Al
参考文献:Journal Of Medicinal Chemistry 日期:2018 卷标:61(20) 页码:9085-9104]

96803-85-9 = 90560-10-4
反应条件:1.1 Reagents: Boron Trifluoride Etherate Solvents: Dichloromethane; 25 - 30 °C
标题:Synthesis Development Of The Selective Estrogen Receptor Degrader (Serd) Lsz102 From A Suzuki Coupling To A C-H Activation Strategy
作者:Baenziger,Markus; Baierl,Marcel; Devanathan,Krishnaswamy; Eswaran,Sumesh; Fu,Peng; Et Al
参考文献:Organic Process Research & Development 日期:2020 卷标:24(8) 页码:1405-1419]

17347-32-9 = 90560-10-4
反应条件:1.1 Catalysts: Copper Bromide (Cubr) Solvents: Methanol,Dimethylformamide; 7 H,110 °C
标题:Benzo[b]Naphtho[1,2-D]Thiophene Sulfoxides: Biomimetic Synthesis,Photophysical Properties,And Applications
作者:Shen,Xian-Yan; Li,Man; Zhou,Tai-Ping; Huang,Ji-Rong
参考文献:Angewandte Chemie 日期:2022 卷标:61(35)]

96803-85-9 = 90560-10-4
反应条件:1.1 Reagents: Boron Trifluoride Etherate Solvents: Dichloromethane; Rt
标题:Concise Synthesis And Biological Evaluation Of 2-Aryl-3-Anilinobenzo[b]Thiophene Derivatives As Potent Apoptosis-Inducing Agents
作者:Romagnoli,Romeo; Preti,Delia; Hamel,Ernest; Bortolozzi,Roberta; Viola,Giampietro; Et Al
参考文献:Bioorganic Chemistry 日期:2021 卷标:112

6-Methoxy-Benzothiophene-3-Ol置于盐酸,Amalgamated Tin,甲苯体系中,化学反应生成 6-甲氧基苯并噻吩
参考文献:Perold; Van Lingen,Chemische Berichte,1959,Vol. 92,P. 293,297
标题:Perold; Van Lingen,Chemische Berichte,1959,Vol. 92,P. 293,297

海关参考信息

2905110000-甲醇
2908199090-其他酚的卤化衍生物
2908999090-其他酚的硝化衍生物
2918290000-其他含酚基羧酸
💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
详情请参考：📖 海关编码查询和海关进出口税则

专利信息

专利号:US-2005192265-A1
优先权日:2003-03-20
标题:Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting beta-amyloid peptide release and/or its synthesis by use of such compounds
发明人：THOMPSON RICHARD C; WILKIE STEPHEN; STACK DOUGLAS R; VANMETER ELDON E; SHI QING; BRITTON THOMAS C; AUDIA JAMES E; REEL JON K; MABRY THOMAS E; DRESSMAN BRUCE A; CWI CYNTHIA L; HENRY STEVEN S; MCDANIEL STACEY L; STUCKY RUSSELL D; PORTER WARREN J
摘要:Disclosed are compounds which inhibit Î²-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions that include a compound which inhibits Î²-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

专利号:EP-0946499-B1
优先权日:1996-11-22
标题 :N-(aryl/heteroaryl/alkylacetyl) amino acid amides, pharmaceutical compositions comprising same, and methods for inhibiting beta-amyloid peptide release and/or its synthesis by use of such compounds
发明人：WU JING; TUNG JAY S; NISSEN JEFFREY S; MABRY THOMAS E; LATIMER LEE H; EID CLARK NORMAN; AUDIA JAMES E
权利人:ELAN PHARM INC; LILLY CO ELI
摘要:Disclosed are compounds which inhibit beta -amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits beta -amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions. Said compounds are represented by formula (I), wherein R<1> is selected from the group consisting of: a) alkyl, alkenyl, alkaryl, alkcycloalkyl, aryl, cycloalkyl, cycloalkenyl, heteroaryl and heterocyclic; b) a substituted phenyl group of formula (II), wherein R is alkylene of from 1 to 8 carbon atoms, m is an integer equal to 0 or 1, and c) 1- or 2-naphthyl substituted at the 5, 6, 7 and/or 8 positions, R<2> is selected from the group consisting of hydrogen, alkyl of from 1 to 4 carbon atoms, alkylalkoxy of from 1 to 4 carbon atoms, alkylthioalkoxy of from 1 to 4 carbon atoms; and R<3> and R<3'> are independently selected from the group consisting of: (a) hydrogen, (b) alkyl, (c) -(R<7>)n(W)p, wherein R<7> is an alkylene group, W is selected from the group consisting of (i) formula (A); (ii) heteroaryl; and (iii) N-heterocyclic, and n is an integer equal to 0 or 1, and p is an integer equal to 1 to 3; (d) -CH( phi )CH2C(O)O-Q where Q is selected from the group consisting of alkyl, aryl, heteroaryl and heterocyclic; X' is hydrogen, hydroxy or fluoro; X'' is hydrogen, hydroxy or fluoro, or X' and X'' together form an oxo group, Z is selected from the group consisting of a bond covalently linking R<1> to -CX'X''-, oxygen and sulfur.

专利号:WO-9967219-A1
优先权日:1998-06-22
标题:Compounds for inhibiting beta-amyloid peptide release and/or its synthesis
发明人：AUDIA JAMES E; PORTER WARREN J; THOMPSON RICHARD C; WILKIE STEPHEN C; STACK DOUGLAS R; SHI QING
权利人:ELAN PHARM INC; LILLY CO ELI; AUDIA JAMES E; PORTER WARREN J; THOMPSON RICHARD C; WILKIE STEPHEN C; STACK DOUGLAS R; SHI QING
摘要:Compounds of formula (I), wherein W is a cyclic group of the type (2); (3); Y is represented by the formula (II); these compounds inhibit Î²-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits Î²-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

专利号:US-6774125-B2
优先权日:1998-06-22
标题:Deoxyamino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting Î²-amyloid peptide release and/or its synthesis by use of such compounds
发明人：AUDIA JAMES E; THOMPSON RICHARD C; WILKIE STEPHEN C; BRITTON THOMAS C; PORTER WARREN J; HUFFMAN GEORGE W; LATIMER LEE H
权利人:ELAN PHARM INC; LILLY CO ELI
摘要:Disclosed are compounds which inhibit Î²-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits Î²-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

专利号:US-6509331-B1
优先权日:1998-06-22
标题:Deoxyamino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting Î²-amyloid peptide release and/or its synthesis by use of such compounds
发明人：AUDIA JAMES E; THOMPSON RICHARD C; WILKIE STEPHEN C; BRITTON THOMAS C; PORTER WARREN J; HUFFMAN GEORGE W; LATIMER LEE H
权利人:ELAN PHARM INC; LILLY CO ELI
摘要:Disclosed are compounds which inhibit beta-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits beta-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

专利号:US-6849650-B2
优先权日:1998-02-27
标题:Heterocyclic compounds, pharmaceutical compositions comprising same, and methods for inhibiting Î²-amyloid peptide release and/or its synthesis by use of such compounds
发明人：THORSETT EUGENE D; PORTER WARREN J; NISSEN JEFFREY S; LATIMER LEE H; AUDIA JAMES E; DROSTE JAMES
权利人:ATHENA NEUROSCIENCES INC; LILLY CO ELI
摘要:Disclosed are compounds which inhibit Î²-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits Î²-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.