CAS: 92-83-1; 9H-Xanthene

该化合物其结构特征为有机化合物,由由两个苯环和一个中央烟火环组成的引信环系统组成,它看起来无色可粉黄固态,因其荧光特性而闻名,在各种应用中,包括在荧光染色和荧光标记生产中都有用.Xanthene的分子配方为C13H10O,分子重量约为194.22克/摩尔.在正常条件下,它相对稳定,但一旦暴露在光线下,它可以发生光化学反应.Xanthene衍生物,如氟辛和萝卜,由于其独特的化学特性,在生物和化学研究中广泛使用,在生物和化学衍生物中广泛使用,该化合物在乙醇和醚等有机溶剂中可溶性,但在水中溶性有限.安全考虑包括谨慎处理,因为如果浸入或吸入,可能会对健康造成危害.总的来说,Xanne因其独特的化学特性,在学术和工业环境中都是一种重要的化合物.

结构式图片

欧盟法规

ECHA物质ECHA物质C&L通报REACH预注册

上下游产品

CAS号90-47-1 呫吨酮 | CAS号492-21-7 xanthene-9-thione | CAS号90-46-0 占吨氢醇 | CAS号90-02-8 水杨醛 | CAS号88284-48-4 2-(三甲基硅)苯基三氟甲烷磺酸盐 | CAS号930-68-7 环己烯酮 | CAS号822-36-6 4-甲基咪唑 | CAS号76-54-0 2',7'-二氯荧光素 | CAS号95-51-2 2-氯苯胺 | CAS号75-91-2 叔丁基过氧化氢 | CAS号542-28-9 δ-戊内酯 | CAS号71340-82-4 rac-9-(1'-ox°Cy... | CAS号4132-48-3 4-异丙基苯甲醚 | CAS号517-45-3 9,9'-二亚呫吨 | CAS号4132-49-4 1-tert-butyl-4-... | CAS号2621-46-7 4-chlor°Cumene | CAS号13816-33-6 4-异丙基苯甲腈 | CAS号2523-37-7 9-甲基-9H-芴 | CAS号98-82-8 异丙基苯 | CAS号90-46-0 占吨氢醇

合成工艺路线路线简述

  • 合成目标产物 Xanthene 主要起始原料 Xanthone
  • 90-47-1 = 92-83-1
    反应条件:1.1 Reagents: Sodium Borohydride Solvents: Tetrahydrofuran; Rt -> 0 °C; 1 H,0 °C1.2 Reagents: Chlorotrimethylsilane Solvents: Tetrahydrofuran; 10 °C; 10 H,0 °C
    标题:Method For The Preparation Of Xanthene
    参考文献:Japan]

    90-47-1 = 92-83-1
    反应条件:1.1 Reagents: Aluminum Chloride,Lithium Aluminum Hydride1.2 Reagents: Hydrogen Ion Solvents: Water
    标题:Synthesis Of Dihydrodibenzo[b,F]Furo[2,3-D]Oxepins And Related Reactions
    作者:Maemura,Yasunobu; Tanoue,Yuka; Nishino,Hiroshi
    参考文献:Heterocycles 日期:2012 卷标:85(10) 页码:2491-2503]

    90-47-1 = 92-83-1
    反应条件:1.1 Reagents: Trifluoroacetic Acid,Triethylsilane; Rt; 1 H,Rt1.2 Reagents: Sodium Hydroxide Solvents: Water; 1 H,Basified,Rt
    标题:Preparation Of High-Purity Xanthene
    参考文献:Japan]

    27805-65-8 = 92-83-1
    反应条件:1.1 Reagents: N,N-Diethylaniline
    标题:The Retro-Diels-Alder Reaction. Part Ii. Dienophiles With One Or More Heteroatom
    作者:Rickborn,Bruce
    参考文献:Organic Reactions (Hoboken 日期:1998 卷标:53]

    90-47-1 = 92-83-1
    反应条件:1.1 Reagents: Formic Acid,Hydrochloric Acid,Sodium Chloride Solvents: Acetonitrile,Water; 1 H,23 °C
    标题:A Process For The Deoxy Reduction Of Aldehydeketones To The Corresponding Saturated Hydrocarbons
    参考文献:China]

    260-92-4 + 37181-39-8 = 92-83-1
    反应条件:1.1 Reagents: Ethylene Glycol,Sodium Carbonate Catalysts: Cupric Acetate Solvents: Dimethylformamide,Water; 12 H,100 °C
    标题:Copper-Catalyzed One-Pot Synthesis Of Dibenzofurans,Xanthenes,And Xanthones From Cyclic Diphenyl Iodoniums
    作者:Zhu,Daqian; Li,Min; Wu,Zhouming; Du,Yongliang; Luo,Bingling; Et Al
    参考文献:European Journal Of Organic Chemistry 日期:2019 卷标:2019(28) 页码:4566-4571]

    492-21-7 = 92-83-1
    反应条件:1.1 Reagents: Tellurium Solvents: Dimethylformamide,Tetrahydrofuran
    标题:Reduction Of Aromatic Nitro Compounds And Thioketones With Sodium Telluride Under Aprotic Conditions
    作者:Suzuki,Hitomi; Manabe,Hajime; Kawaguchi,Takashi; Inouye,Masahiko
    参考文献:Bulletin Of The Chemical Society Of Japan 日期:1987 卷标:60(2) 页码:771-2]

    190837-45-7 = 92-83-1
    反应条件:1.1 Solvents: Toluene
    标题:Polycyclic Aromatic Hydrocarbons. 7. A New Route For The Preparation Of Xanthene Derivatives Using Friedel-Crafts Intramolecular Cyclobenzylation
    作者:Yamato,Takehiko; Komine,Masayasu; Nagano,Yoshiaki
    参考文献:Organic Preparations And Procedures International 日期:1997 卷标:29(3) 页码:300-303]

    90-47-1 = 92-83-1
    反应条件:1.1 Reagents: Dabco Catalysts: Tetrabutylammonium Tetrafluoroborate Solvents: Dimethylformamide; 5 H,Rt
    标题:Electrochemical Reduction Of Aldehydes And Ketones For The Synthesis Of Alcohols And Diols Under Ambient Conditions
    作者:Wang,Lei; Zhang,Xiao; Xia,Raymond Yang; Yang,Chao; Guo,Lin; Et Al
    参考文献:Synlett 日期:2022 卷标:33(13) 页码:1302-1308]

    90-47-1 = 92-83-1
    反应条件:1.1 Reagents: Diborane Solvents: Tetrahydrofuran
    标题:Diborane Reduction Of Aromatic Systems. Course Of The Reduction-Elimination Of Xanthone,Thioxanthone,And 9(10H)-Acridone To Their Corresponding Hydrocarbons
    作者:Wechter,Wm. J.
    参考文献:Journal Of Organic Chemistry 日期:1963 卷标:28(10) 页码:2935-6]

    27063-50-9 = 92-83-1
    反应条件:1.1 Solvents: Diethyl Ether,Benzene
    标题:Reactions With Halogen-Substituted Xanthones. Ii
    作者:Mustafa,Ahmed; Asker,Wafia; Sobhy,Mohamed Ezz El-Din
    参考文献:Journal Of The American Chemical Society 日期:1955 卷标:77 页码:5121-4]

    = 92-83-1
    反应条件:1.1 Reagents: Cesium Fluoride Solvents: Toluene; 24 H,150 °C
    标题:A C-To-O Atom-Swapping Reaction Sequence Enabled By Ni-Catalyzed Decarbonylation Of Lactones
    作者:Luu,Quang H.; Li,Junqi
    参考文献:Chemical Science 日期:2022 卷标:13(4) 页码:1095-1100]

    90-47-1 = 92-83-1
    反应条件:1.1 Reagents: Phenylsilane Catalysts: Diaquadichlorodioxomolybdenum Solvents: Diethyl Ether,Toluene; 16 H,Reflux
    标题:Highly Efficient Deoxygenation Of Aryl Ketones To Arylalkanes Catalyzed By Dioxidomolybdenum Complexes
    作者:Sousa,Sara C. A.; Fernandes,Tiago A.; Fernandes,Ana C.
    参考文献:European Journal Of Organic Chemistry 日期:2016 卷标:2016(18) 页码:3109-3112]

    90-47-1 = 92-83-1
    反应条件:1.1 Reagents: Sodium Borohydride Solvents: Ethanol,Tetrahydrofuran; Rt; 4 H,Rt -> 40 °C
    标题:Gold-Containing Metal Complex,Mixture,Composition,And Organic Electronic Device
    参考文献:China]

    90-47-1 = 92-83-1
    反应条件:1.1 Reagents: (Dimethyl Sulfide)Trihydroboron Solvents: Tetrahydrofuran; 1 H,75 - 80 °C1.2 Reagents: Hydrochloric Acid,Sodium Chloride Solvents: Water
    标题:High-Fidelity Dimerization Of Xanthenyl Radicals And Dynamic Qualities Of A Congested Ethane: Diethyl Dixanthenyl-9,9'-Dicarboxylate
    作者:Hogan,David T.; Dubrawski,Zachary; Gelfand,Benjamin S.; Sutherland,Todd C.
    参考文献:European Journal Of Organic Chemistry 日期:2022 卷标:2022(1)]

    19434-34-5 = 92-83-1
    反应条件:1.1 Catalysts: Titanium Tetrachloride Solvents: Dichloromethane; 24 H,Rt1.2 Reagents: Triethylsilane; 12 H,Rt1.3 Reagents: Water
    标题:Formation And Disproportionation Of Xanthenols To Xanthenes And Xanthones And Their Use In Synthesis
    作者:Shi,Zeyu; Chen,Si; Xiao,Qiong; Yin,Dali
    参考文献:Journal Of Organic Chemistry 日期:2021 卷标:86(4) 页码:3334-3343]

    90-46-0 = 92-83-1
    反应条件:1.1 Reagents: Triethylsilane Catalysts: Gallium(1+),[1,3-Bis[2,6-Bis(1-Methylethyl)Phenyl]-1,3-Dihydro-2H-Imidazol-2-Yl... Solvents: 1,2-Dichloroethane; 1 H,Rt
    标题:Catalytic Applications Of [ipr.Gax2][sbf6] And Related Species
    作者:Michelet,Bastien; Tang,Shun; Thiery,Guillaume; Monot,Julien; Li,Huijing; Et Al
    参考文献:Organic Chemistry Frontiers 日期:2016 卷标:3(12) 页码:1603-1613]

    90-47-1 = 92-83-1
    反应条件:1.1 Reagents: Diethylene Glycol,Potassium Hydroxide,Hydrazine,Hydrate Solvents: Water; Rt -> 135 °C; 3 H,130 - 135 °C
    标题:Method For Preparing Xanthene-9-Carboxylic Acid
    参考文献:China]

    90-47-1 = 92-83-1
    反应条件:1.1 Reagents: Tetrabutylammonium Tetrafluoroborate,Diisopropylethylamine Solvents: Acetonitrile,Tetrahydrofuran; 6 H,Rt
    标题:Electrochemical Reduction Of Diarylketones And Aryl Alkenes
    作者:Bi,Ce; Zhao,Xiangyu; Jia,Zhiqi; Chang,Yongxin; Yang,Hang; Et Al
    参考文献:Chemcatchem 日期:2023 卷标:15(9)
9H-氧杂蒽-9-甲醇 以 水,乙腈 作为反应溶剂,化学反应生成 氧杂蒽
参考文献:General Method For The Photogeneration Of Benzolated Cationic And Anionic Systems In Aqueous Solution. Test Of Relative Stability Of These Systems In The Excited State.
标题:General Method For The Photogeneration Of Benzolated Cationic And Anionic Systems In Aqueous Solution. Test Of Relative Stability Of These Systems In The Excited State.
摘要:
DOI:10.1016/s0040-4039(00)84110-6

海关参考信息

专利信息


专利号:US-7160517-B2
优先权日:2000-08-18
标题 :Apparatus and methods for the automated synthesis of oligosaccharides
发明人:SEEBERGER PETER H; PLANTE OBADIAH J
权利人:MASSACHUSETTS INST OF TECHNOLG
摘要:One aspect of the present invention relates to an apparatus for the efficient synthesis of oligosaccharides on a solid support, e.g., formed by subunit addition to terminal subunits immobilized on solid-phase particles. In certain embodiments, the apparatus of the present invention is used in combinatorial methods, e.g., as described herein, of synthesizing oligosaccharides.

专利号:US-7301006-B2
优先权日:2002-07-16
标 题 :Methods and materials for the synthesis of modified peptides
发明人:YOUNG TRAVIS G; KIESSLING LAURA L
权利人:WISCONSIN ALUMNI RES FOUND
摘要:Methods and protected amino acids useful as building blocks (protected monomers) for the synthesis of peptides and proteins that are selectively modified at one or more side-chain hydroxyl groups. Azide-bearing protecting groups allow the selective deprotection of side-chain hydroxyl groups of amino acids after synthesis of a peptide. Reaction conditions for removal of the azide-bearing protecting group can be selected which are substantially orthogonal to those that will remove α-amino protecting groups typically employed in peptide synthesis, such that hydroxyl groups protected with the azide-bearing protecting group remain protected during synthesis of the peptide chain. Various protecting groups which are readily available can be used for protecting potentially reactive side chain groups of amino acids in the peptide or protein to be modified. Preferred side-chain protecting groups are chemically distinguishable from the azide-bearing protecting group and substantially orthogonal reaction conditions can be selected such that side-chain protection of other amino acids is maintained when the azide-bearing protecting group is removed. The use of the azide-bearing protecting group of this invention for one or more hydroxy amino acids during peptide synthesis allows the selective unmasking of those azide-protected side-chain hydroxyl groups and selective modification of the hydroxyl groups that are selectively unmasked. The methods and materials herein are particularly used in synthesis of sulfated, phosphorylated and glycosylated peptides and proteins. Kits and methods of synthesizing a modified peptide or protein using the kits are also provided.

专利号:US-5824472-A
优先权日:1986-03-24
标 题 :Process for the synthesis of sugar nucleotides using recombinant-DNA methods
发明人:BETLACH MICHAEL R; DOHERTY DANIEL H; VANDERSLICE REBECCA W
权利人:MONSANTO CO
摘要:A recombinant-DNA mediated method for the synthesis of sugar nucleotides is disclosed. This method utilizes portable DNA sequences capable of directing the microbial synthesis of various enzymes that catalyze the synthesis of sugar nucleotides, including UDP-glucose, UDP-glucuronic acid and GDP-mannose. The sugar moieties of these sugar nucleotides may subsequently be incorporated into industrially-useful polysaccharides such as xanthan gum. It has been found that vectors containing the portable DNA sequences described herein are capable both of causing sugar nucleotide production in microorganisms previously incapable of such synthesis and of causing increased sugar nucleotide production in organisms capable of synthesizing small quantities of these compounds. In particular, plasmids pAS7, pAS9 and pTS13 are disclosed. These plasmids are capable of directing sugar nucleotide synthesis in various hosts, including Xanthomonas sp. such as X. campestris and other organisms such as E. coli and various Pseudomonas sp.

专利号:US-7589170-B1
优先权日:1998-09-25
标题 :Synthesis of cyclic peptides
发明人:SMYTHE MARK LESLIE; MEUTERMANS WIM DENIS FRANS; BOURNE GREGORY THOMAS; MCGEARY ROSS PETER
权利人:UNIV QUEENSLAND
摘要:This invention relates to methods for preparing cyclic peptides and peptidomimetic compounds in solution and bound to solid supports, and to cyclic peptide or peptidomimetic libraries for use in drug screening programs. In particular, the invention relates to a generic strategy for synthesis of cyclic peptides or peptidomimetics that enables the efficient synthesis under mild conditions of a wide variety of desired compounds. Two approaches were evaluated for their improvements in solution and solid phase synthesis of small cyclic peptides: positioning reversible N-amide substituents in the sequence; and applying native ligation chemistry in an intramolecular sense. Systematic investigation of the effects of preorganising peptides prior to cyclisation by using peptide cyclisation auxiliaries, and developing new linkers and peptide cyclisation auxiliaries to aid cyclic peptide synthesis gives surprising improvements in both yields and purity of products compared to the prior art methods. The combination of these technologies provides a powerful generic approach for the solution and solid phase synthesis of small cyclic peptides. The ring contraction and N-amide substitution technology of the invention provide improved methods for the synthesis of cyclic peptides and peptidomimetics. When used in conjunction with linker strategies, this combination provides solid-phase avenues to cyclic peptides and peptidomimetics.

专利号:US-7230101-B1
优先权日:2002-08-28
标 题:Synthesis of methotrexate-containing heterodimeric molecules
发明人:MURTHI KRISHNA K; SMITH CHASE C
权利人:GPC BIOTECH INC
摘要:The present invention relates to novel compositions of methotrexate-containing heterodimeric probe molecules, also known as chemical inducers of dimerization (CID), useful in three-hybrid assays. The invention further relates to synthesis of said compositions and their intermediates. Another aspect of the invention is a method for using the heterodimeric probe molecules described herein in drug screens to identify potential protein targets to a given ligand, optimize protein-ligand interactions, or identify potential ligands for a given protein target. In certain embodiments, the invention contemplates the synthesis of the following methotrexate-containing heterodimeric probe:

专利号:US-6770436-B1
优先权日:1996-11-14
标题:Chemical amplification for the synthesis of patterned arrays
发明人:BEECHER JODY E; GOLDBERG MARTIN J; MCGALL GLENN H
权利人:AFFYMETRIX INC
摘要:Radiation-activated catalysts (RACs), autocatalytic reactions, and protective groups are employed to achieve a highly sensitive, high resolution, radiation directed combinatorial synthesis of pattern arrays of diverse polymers. When irradiated, RACs produce catalysts that can react with enhancers, such as those involved in autocatalytic reactions. The autocatalytic reactions produce at least one product that removes protecting groups from synthesis intermediates. This invention has a wide variety of applications and is particularly useful for the solid phase combinatorial synthesis of polymers.
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主要参考文献

[参考文献]: Alfonso Pérez-Garrido, Et Al. Convenient Qsar Model For Predicting The Complexation Of Structurally Diverse Compounds With Beta-Cyclodextrins. Bioorg Med Chem. 2009 Jan 15;17(2):896-904.

合成参考文献


参考文献:10.1007/s10895-011-0919-y
摘要:Shanker N, Dilek O, Mukherjee K, McGee DW, Bane SL. Aurones: Small Molecule Visible Range Fluorescent Probes Suitable for Biomacromolecules. Journal of Fluorescence. 2011 Jul 12;21(6):2173. doi: 10.1007/s10895-011-0919-y.
参考文献:10.1107/s1600536811007318
摘要:Abdelhamid AA, Mohamed SK, Allahverdiyev MA, Gurbanov AV, Ng SW. 3,3,6,6-Tetra-methyl-9-[6-(3,3,6,6-tetra-methyl-1,8-dioxo-2,3,4,5,6,7,8,9-octa-hydro-1H-xanthen-9-yl)pyridin-2-yl]-2,3,4,5,6,7,8,9-octa-hydro-1H-xanthene-1,8-dione. Acta Crystallogr Sect E Struct Rep Online. 2011 Apr 01;67(Pt 4):o785.
参考文献:10.1107/s1600536811008658
摘要:Mohamed SK, Abdelhamid AA, Khalilov AN, Gurbanov AV, Ng SW. 4a-Hy-droxy-3,3,6,6-tetra-methyl-9-[6-(3,3,6,6-tetra-methyl-1,8-dioxo-2,3,4,5,6,7,8,9-octa-hydro-1H-xanthen-9-yl)pyridin-2-yl]-2,3,4,4a,5,6,7,8,9,9a-deca-hydro-1H-xanthene-1,8-dione ethanol hemisolvate hemihydrate. Acta Crystallogr Sect E Struct Rep Online. 2011 Apr 01;67(Pt 4):o850–1.
参考文献:10.1016/j.saa.2011.06.038
摘要:Chakraborty M, Panda AK. Spectral behaviour of eosin Y in different solvents and aqueous surfactant media. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy. 2011 Oct;81(1):458–65. doi: 10.1016/j.saa.2011.06.038.
参考文献:10.1166/jnn.2011.3741
摘要:Bardhan M, Mandal G, Ganguly T. Interaction and photodegradation characteristics of fluorescein dye in presence of ZnO nanoparticles. J Nanosci Nanotechnol. 2011 Apr;11(4):3418–26. doi: 10.1166/jnn.2011.3741.
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