CAS: 119736-16-2; 3-(Benzyloxy)-4-Oxo-4H-Pyran-2-Carboxylic Acid

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1332855-94-3 1332855-89-6 500371-01-7

上下游产品

2-(hydroxymethyl)-3-(phenylmethoxy)-4H-pyran-4-one 3-(benzyloxy)-4-oxo-4H-pyran-2-carbaldehyde Maltol 3-O-benzylmaltol 3-benzyloxy-4-oxo-4H-pyran-2-carboxylic acid 2,5-dioxo-pyrrolidin-1-yl ester N,N',N''-(nitrilotris(ethane-2,1-diyl))tris(3-(benzyloxy)-4-oxo-4H-pyran-2-carboxamide) 3-benzyloxy-5-bromo-4-oxo-4H-pyrane-2-carboxylic acid methyl ester 3-benzyloxy-4-oxo-4H-pyran-2-carboxylic acid 4-fluorobenzylamide

麦芽醇置于selenium(Iv) Oxide,Sodium Hypochlorite,氨基磺酸,Sodium Hydroxide体系中,用 甲醇,水,丙酮 用作溶剂,化学反应 24.0H,反应生成3-(苄氧基)-4-氧代-4H-吡喃-2-羧酸
参考文献:一系列新的六价铁(III)螯合剂的合成,理化性质和抗菌评估
标题:一系列新的六价铁(III)螯合剂的合成,理化性质和抗菌评估
摘要:摘要已经合成了一系列相关的3-羟基吡啶-4-一六齿配体.发现这些螯合剂对铁(III)具有高亲和力,Pfe值约为30.由于铁是细菌存活的关键元素,因此预计这些螯合剂会通过破坏细菌对铁的吸收来抑制细菌的生长. .实际上,已证明它们对革兰氏阳性和革兰氏阴性细菌均具有明显的抑制活性,因此它们具有作为抗菌剂的潜力.发现1C和1G对革兰氏阴性菌特别有效. 图形概要已经合成了一系列相关的3-羟基吡啶-4-一六齿配体.发现这些螯合剂对铁(III)具有很高的亲和力,并且对革兰氏阳性和革兰氏阴性细菌均表现出明显的抑制活性,因此,它们具有作为抗菌剂的潜力.
Doi:10.1007/s00044-012-0229-1

专利信息

专利号:US-12435042-B2
优先权日:2019-07-04
标题:Process for the preparation of key intermediates for the synthesis of Eltrombopag or salt thereof
发明人：STABILE PAOLO; SEMERARO FLORIANA
权利人:F I S —FABBRICA ITALIANA SINTETICI S P A
摘要:Object of the present invention is an improved process for the preparation of key intermediates for the synthesis of Eltrombopag, passing through/using intermediate 5′-Chloro-2′-hydroxy[1,1′-biphenyl]-3-carboxylic acid alkaline metal salt of formula: wherein A is an alkaline metal.

专利号:US-9365587-B2
优先权日:2008-12-11
标 题:Synthesis of carbamoylpyridone HIV integrase inhibitors and intermediates
发明人：YOSHIDA HIROSHI; TAODA YOSHIYUKI; JOHNS BRIAN ALVIN; KAWASUJI TAKASHI; NAGAMATSU DAIKI
权利人:SHIONOGI & CO; VIIV HEALTHCARE CO
摘要:The invention is a process for the preparation of a compound of the following formula (I): n nwherein R is —CHO, —CH(OH) 2 or —CH(OH)(OR 4 ); P 1 is H or a hydroxyl protecting group; P 3 is H or a carboxy protecting group; R 3 is H, halogen, hydroxy, optionally substituted lower alkyl, optionally substituted cycloalkyl, etc.; R x is H, halogen or R 2 —X—NR 1 —C(O)—; etc. as defined in the specification. The compounds are useful as intermediates in synthesizing compounds having HIV integrase inhibitory activity.

专利号:WO-2013049605-A1
优先权日:2011-09-28
标题 :Processes for the preparation of an intermediate in the synthesis of eltrombopag
发明人：AVDAGIC AMIR; BARAN PHIL S
权利人:ASSIA CHEM IND LTD; TEVA PHARMACEUTICAL USA INC
摘要:3'-Amino-2'-hydroxybiphenyl-3-carboxylic acid (BPCA) and related compounds have been prepared using compounds such as: wherein R 1 is -H, -Cl or -F; R 2 is -Br or -I; and R 3 is -H or -N0 2 . BPCA is useful, for example, in the preparation of Eltrombopag.

专利号:US-2022298116-A1
优先权日:2019-07-04
标题:Process for the preparation of key intermediates for the synthesis of eltrombopag or salt thereof

专利号:US-2016326600-A1
优先权日:2014-01-29
标题:Economical molecules for specific binding and detection of nucleic acids using universal functionalized strands
发明人：ZHANG DAVID YU; WANG JUEXIAO
权利人:UNIV RICE WILLIAM M
摘要:Nucleic acid probes are described comprising a universal component and a target dependent component. The universal component provides an economical advantage in that the universal component can retain any desired functional moiety, such as a fluorophore or other label which can be used with any target dependent component. Thus, the cost of designing target specific functionalized probes is significantly reduced with this probe system by limiting de novo synthesis to only the target dependent component of the probe for each desired target nucleic acid. Furthermore, the probe design of the present disclosure provides high target specificity demonstrating selective binding of the target in a 1% target load sample.

专利号:CN-114072386-A
优先权日:2019-07-04
标题 :Improved process for the preparation of key intermediates for the synthesis of eltrombopag or salts thereof