专利号:US-6013622-A 优先权日:1998-04-15 标题:Method of regulating appetite and metabolism 发明人:BRUNO JOHN F; WHITE JEFFREY; BERELOWITZ MICHAEL; TRIPODI DANIEL; HEIL MATTHEW 权利人:NUTRICEUTICAL TECHNOLOGY CORP; UNIV NEW YORK STATE RES FOUND 摘要:Methods and compositions capable of controlling weight in an animal, preferably a human, which methods involve administering diet compositions that modulate, and preferably reduce, synthesis and secretion of neuropeptide Y (NPY) and modulate, and preferably increase synthesis and secretion of growth hormone releasing factor (GRF), compared to pre-administration amounts in the animal. The administration of such diet compositions results in a reduced appetite and a regulated metabolism that enhance weight control, including weight loss and reduction of obesity.
专利号:WO-2005097092-A1 优先权日:2004-04-05 标 题 :Compound with vitamin k activity, particularly as additive for feeds, and preparation of the compound 发明人:BRUSCHI ENRICO; MONTELEONE FRANCESCO 权利人:VANETTA S P A; BRUSCHI ENRICO; MONTELEONE FRANCESCO 摘要:A new indication of use for bis(menadione bisulfite)piperazine (MBP) and a method for synthesizing the compound is described. MBP has a substantial vitamin K-like activity, which however, differently from other compounds currently in use for the same purpose, is associated with a considerable stability in conditions of intense physical stress, with high activity per unit weight, and a low danger index (assessed by means of an EC protocol that is adopted universally in the field for this purpose). The described synthesis method is based on the low water-solubility constant of MBP, so that as a consequence of the mixing of a menadione bisulfite salt and a second piperazine salt one obtains a complete precipitation of the salt of interest, which can thus be separated and purified easily.
专利号:US-6800663-B2 优先权日:2002-10-18 标 题:Crosslinked hydrogel copolymers 发明人:ASGARZADEH FIROUZ; COSTANTINO HENRY R 权利人:ALKERMES INC 摘要:The present invention relates to crosslinked polymers, synthesized through ring-opening polymerization of ethylenically unsaturated epoxides, in combination with α-hydroxy acids using a hydrophilic macroinitiator, such as poly(ethylene glycol), to form substituted copolymers having ethylenically unsaturated functionality randomly distributed along the polyester polymer backbone. That copolymer is subsequently crosslinked to form a hydrogel network. More particularly, the present invention relates to the synthesis of biodegradable poly(α-hydroxy acid-co-glycidyl methacrylate)-block-poly(ethylene glycol)-block-poly(α-hydroxy acid-co-glycidyl methacrylate) copolymers, which are subsequently crosslinked to form hydrogel networks. The invention also relates to the use of these hydrogel networks in various applications, in particular, for the controlled release of drugs and proteins.
专利号:RU-1803401-C 优先权日:1990-04-02 标题:Method of 2- methyl -1,4- naphthoquinone synthesis
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