CAS: 130-37-0; Menadione Bisulfite (Sodium)

该化合物是一种合成合成化合物,产自环烷磺酸钠,主要因其作为维生素K前体的作用而得到承认,用于各种生化应用,特别是在营养和医药领域;该化合物呈现黄色至橙色,在水中可溶解,可提高其生物利用率;该化合物的结构特征是:一个凝固的丙酮核心,在2位置有一个甲基组,一个双硫酸钠有助于其稳定性和溶解性;该物质因其抗氧化性特性而著称,在血液凝固过程中发挥着关键作用;此外,该物质常常用于细胞培养和研究环境中研究维生素K的代谢和相关的生物化学途径;安全考虑因素包括潜在的皮肤和眼刺激,应在实验室环境中以适当的防范措施加以处理.

结构式图片

相似化合物

73581-79-0 51114-72-8 102226-50-6

欧盟法规

统一分类与标签ECHA物质ECHA物质工作场所安全标识要求C&L通报REACH预注册废弃物危险特性清单

上下游产品

CAS号58-27-5 维生素K3 | CAS号91-57-6 2-甲基萘 | CAS号58-27-5 维生素K3

合成工艺路线路线简述

  • 合成目标产物 Menadione Sodium Bisulfite 主要起始原料 Menadione
  • (文献来源)合成步骤主要原料 Menadione

海关参考信息

专利信息


专利号:US-6013622-A
优先权日:1998-04-15
标题:Method of regulating appetite and metabolism
发明人:BRUNO JOHN F; WHITE JEFFREY; BERELOWITZ MICHAEL; TRIPODI DANIEL; HEIL MATTHEW
权利人:NUTRICEUTICAL TECHNOLOGY CORP; UNIV NEW YORK STATE RES FOUND
摘要:Methods and compositions capable of controlling weight in an animal, preferably a human, which methods involve administering diet compositions that modulate, and preferably reduce, synthesis and secretion of neuropeptide Y (NPY) and modulate, and preferably increase synthesis and secretion of growth hormone releasing factor (GRF), compared to pre-administration amounts in the animal. The administration of such diet compositions results in a reduced appetite and a regulated metabolism that enhance weight control, including weight loss and reduction of obesity.

专利号:WO-2005097092-A1
优先权日:2004-04-05
标 题 :Compound with vitamin k activity, particularly as additive for feeds, and preparation of the compound
发明人:BRUSCHI ENRICO; MONTELEONE FRANCESCO
权利人:VANETTA S P A; BRUSCHI ENRICO; MONTELEONE FRANCESCO
摘要:A new indication of use for bis(menadione bisulfite)piperazine (MBP) and a method for synthesizing the compound is described. MBP has a substantial vitamin K-like activity, which however, differently from other compounds currently in use for the same purpose, is associated with a considerable stability in conditions of intense physical stress, with high activity per unit weight, and a low danger index (assessed by means of an EC protocol that is adopted universally in the field for this purpose). The described synthesis method is based on the low water-solubility constant of MBP, so that as a consequence of the mixing of a menadione bisulfite salt and a second piperazine salt one obtains a complete precipitation of the salt of interest, which can thus be separated and purified easily.

专利号:US-6800663-B2
优先权日:2002-10-18
标 题:Crosslinked hydrogel copolymers
发明人:ASGARZADEH FIROUZ; COSTANTINO HENRY R
权利人:ALKERMES INC
摘要:The present invention relates to crosslinked polymers, synthesized through ring-opening polymerization of ethylenically unsaturated epoxides, in combination with α-hydroxy acids using a hydrophilic macroinitiator, such as poly(ethylene glycol), to form substituted copolymers having ethylenically unsaturated functionality randomly distributed along the polyester polymer backbone. That copolymer is subsequently crosslinked to form a hydrogel network. More particularly, the present invention relates to the synthesis of biodegradable poly(α-hydroxy acid-co-glycidyl methacrylate)-block-poly(ethylene glycol)-block-poly(α-hydroxy acid-co-glycidyl methacrylate) copolymers, which are subsequently crosslinked to form hydrogel networks. The invention also relates to the use of these hydrogel networks in various applications, in particular, for the controlled release of drugs and proteins.

专利号:RU-1803401-C
优先权日:1990-04-02
标题:Method of 2- methyl -1,4- naphthoquinone synthesis
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📌 第三方产品分析报告

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合成参考文献


参考文献:10.1007/bf02786264
摘要:Eder K, Kirchgessner M. Zinc deficiency and the desaturation of linoleic acid in rats force-fed fat-free diets. Biol Trace Elem Res. 1996 Aug;54(2):173–83. doi: 10.1007/bf02786264.
参考文献:10.1007/s10096-008-0487-5
摘要:Robert R, DeRaignac A, Le Moal G, Ragot S, Grollier G. Prognostic factors and impact of antibiotherapy in 117 cases of anaerobic bacteraemia. European Journal of Clinical Microbiology & Infectious Diseases. 2008 Mar 21;27(8):671–8. doi: 10.1007/s10096-008-0487-5.
参考文献:10.1385/bter:96:1-3:179
摘要:Sahin N, Sahin K, Onderci M. Vitamin E and selenium supplementation to alleviate cold-stress-associated deterioration in egg quality and egg Yolk mineral concentrations of Japanese quails. Biological Trace Element Research. 2003 Dec;96(1-3):179–89. doi: 10.1385/bter:96:1-3:179.
参考文献:10.1007/s00438-010-0513-z
摘要:Balázs A, Pócsi I, Hamari Z, Leiter É, Emri T, Miskei M, Oláh J, Tóth V, Hegedűs N, Prade RA, Molnár M, Pócsi I. AtfA bZIP-type transcription factor regulates oxidative and osmotic stress responses in Aspergillus nidulans. Molecular Genetics and Genomics. 2010 Feb 04;283(3):289–303. doi: 10.1007/s00438-010-0513-z.
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