CAS: 131918-61-1; (1R,3R)-5-(2-((1R,3As,7Ar,E)-1-((2R,5S,E)-6-Hydroxy-5,6-Dimethylhept-3-En-2-yl)-7A-Methyloctahydro-4H-Inden-4-Ylidene)Ethylidene)Cyclohexane-1,3-Diol

上下游产品

35H60O4SiC35H60O4Si 29H46O4C29H46O4 29H46O4C29H46O4 1α-hydroxy-25-methoxymethyloxy-19-norvitamin D2

诺龙置于sodium Tetrahydroborate,N-溴代丁二酰亚胺(Nbs),四丁基氟化铵,水,溴,Sodium Amide,Pyridinium Chlorochromate,Sodium Hydroxide体系中,用 四氢呋喃,甲醇,乙醇,二氯甲烷,氯仿,甲苯 用作溶剂,化学反应 105.0H,反应生成帕立骨化醇
参考文献:一种帕立骨化醇的合成工艺
标题:一种帕立骨化醇的合成工艺
摘要:本发明公开了一种帕立骨化醇的合成工艺,以诺龙为原料,经过氧化,维悌希反应,羟基保护,上溴,重排,脱溴化氢,加成,氧化,还原,羟基脱保护,开环得到帕立骨化醇,帕立骨化醇用于预防和治疗继发性甲状旁腺功能亢进症.

专利信息

专利号:WO-2025108575-A1
优先权日:2023-11-21
标 题:Methods of selective deprotection and synthesis of transhydrindane- skeleton-based compounds
发明人：HUBER FLORIAN MAURITIUS ERASMUS
权利人:ROCHE DIAGNOSTICS GMBH
摘要:The present invention relates to methods of selectively deprotecting a transhydrindane-skeleton-based compound comprising at least two different silyl ether groups. The present invention further relates to methods of synthesizing a Vitamin D molecule and to Vitamin D molecules obtainable by such processes. Furthermore, the present invention relates to a compound according to formula (I) comprising two different silyl ether groups, its use in the synthesis of Vitamin D molecules and to methods of producing such a compound.

专利号:US-9221753-B2
优先权日:2004-02-03
标题:Process for the synthesis of vitamin D compounds and intermediates for the synthesis of the compounds
发明人：KASHIWAGI HIROTAKA; ONO YOSHIYUKI
权利人:KASHIWAGI HIROTAKA; ONO YOSHIYUKI; CHUGAI PHARMACEUTICAL CO LTD
摘要:An object of the present invention is to provide a process for synthesizing a vitamin D compound by simple procedures at lower costs. n The present invention provides a process for preparing a vitamin D compound and an intermediate thereof, comprising the step of: (a) mixing a ketone or aldehyde, a Wittig reagent, and a base; or (b) mixing a ketone or aldehyde and a Wittig reagent, and then adding a base to the resulting mixture.

专利号:US-2011319644-A1
优先权日:2006-11-02
标 题:Process for production of 1-hydroxy-19-norcyclovitamin d derivative and intermediate for the production
发明人：TOYODA ASAKO; NAGAI HAZUKI; KONUKI KANAME; TSUCHIDA TOSHIO
权利人:TOYODA ASAKO; NAGAI HAZUKI; KONUKI KANAME; TSUCHIDA TOSHIO
摘要:A cyclovitamin D derivative produced from 25-hydroxyvitamin D is reacted with osmium tetraoxide or a permanganic acid salt to produce a 10,19-diolcyclovitamin D derivative. The 10,19-diolcyclovitamin D derivative is reacted with a perhalogenic acid salt or lead tetraacetate to produce a 10-oxocyclovitamin D derivative. A 1-hydroxycyclovitamin D derivative is produced from the 10-oxocyclovitamin D derivative via a cyclovitamin D derivative and a 1,10-olefincyclovitamin D derivative. The 1-hydrocyclovitamin D derivative is subjected to solvolysis, thereby producing a 1-hydroxy-19-norviatmin D derivative. Thus provided are a novel process for production of 1-hydroxy-19-norcyclovitamin D derivative that is utilizable as an intermediate in the synthesis of 1-hydroxy-19-norvitamin D derivative which is useful as a pharmaceutical agent; and an intermediate for the production.

专利号:US-2007135394-A1
优先权日:2004-02-03
标题 :Process for the synthesis of vitamin d compounds and intermediates for the synthesis of the compounds

专利号:US-10906888-B2
优先权日:2016-07-14
标 题:Pyrimidine carboxamides as inhibitors of Vanin-1 enzyme
发明人：CASIMIRO-GARCIA AGUSTIN; STROHBACH JOSEPH WALTER; HEPWORTH DAVID; LOVERING FRANK ELDRIDGE; CHOI CHULHO; ALLAIS CHRISTOPHE PHILIPPE; WRIGHT STEPHEN WAYNE
权利人:PFIZER
摘要:Compounds, pharmaceutically acceptable salts thereof, are disclosed wherein the compounds have the structure of (I) as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.

专利号:US-10308615-B2
优先权日:2015-05-29
标 题:Heterocyclic compounds as inhibitors of Vanin-1 enzyme
发明人：CASIMIRO-GARCIA AGUSTIN; CONDON JEFFREY SCOTT; FLICK ANDREW CHRISTOPHER; GOPALSAMY ARIAMALA; KIRINCICH STEVEN J; MATHIAS JOHN PAUL; STROBACH JOSEPH WALTER; XIANG JASON SHAOYUN; XING LI HUANG; WANG XIAOLUN
权利人:PFIZER
摘要:Compounds, pharmaceutically acceptable salts thereof, are disclosed wherein the compounds have the structure of n nas defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.